1/48. Crystal deodorant dermatitis: irritant dermatitis to alum-containing deodorant.Two patients developed an irritant dermatitis of the axillae shortly after using an over-the-counter "natural deodorant crystal" product containing alum. We discuss this previously unreported, untoward reaction to alum, an ancient agent with newfound popularity as an alternative health product.- - - - - - - - - - ranking = 1keywords = count (Clic here for more details about this article) |
2/48. acute generalized exanthematous pustulosis associated with oral terbinafine.A case history of acute generalized exanthematous pustulosis (AGEP) following oral terbinafine is reported. A 64-year-old woman presented with a rapidly spreading micropustular eruption 3 days after completing a 28-day course of oral terbinafine. There was a positive family history of psoriasis but no personal history. The clinical presentation and histopathology were consistent with AGEP. There was nearly complete resolution of the pustular eruption within 3.5 weeks following cessation of oral terbinafine and treatment with topical and systemic corticosteroids. The patient has remained free of any recurrence 18 months later. A summary of drugs known to be associated with AGEP is presented. Prompt recognition of AGEP is stressed in order to avoid confusion with acute generalized pustular psoriasis or a systemic infection. The most important aspect of management is the immediate withdrawal of the suspect drug.- - - - - - - - - - ranking = 0.014074955711682keywords = spread (Clic here for more details about this article) |
3/48. acute generalized exanthematous pustulosis (AGEP), an uncommon condition in children: case report and review of the literature.acute generalized exanthematous pustulosis (AGEP) is characterized by acute onset of a widespread pustular eruption in association with fever. It is usually seen as a medication reaction. We describe a 17-month-old boy with AGEP secondary to exposure to amoxicillin. This is an uncommon condition in children.- - - - - - - - - - ranking = 0.014074955711682keywords = spread (Clic here for more details about this article) |
4/48. leukemia cutis in an elderly patient treated with low dose cytosine arabinoside and etoposide.A 78-year-old man presented with a generalized erythematous papular rash. Such skin lesions were not painful, tender or pruritic, and spread over the truncus. He was admitted to our hospital for examination of the skin lesions. Laboratory tests indicated microcytic hypochromatic anemia and thrombocytopenia, although gave a normal leukocyte count with normal differentiation. His bone marrow showed hypercellularity, with 43% peroxidase positive blasts that displayed positive immunophenotypes for CD4, CD13, CD33, CD41a, KP-1 (CD68), and HLA-DR. His skin specimen revealed infiltration in the dermis and subcutaneous fat tissue by leukemic cells that were positive for the leukocyte common antigen (LCA, CD45), CD15, CD33, CD68, and HLA-DR. He was diagnosed as having M4 subtype of acute myelogeneous leukemia (AML) with leukemia cutis. After three courses of low dose cytosine arabinoside (LDAC), combined with low dose etoposide, he achieved complete remission (CR). He remained well, with no evidence of relapse nine months later. LDAC should be considered as initial treatment for such cases of leukemia cutis with poor general condition.- - - - - - - - - - ranking = 1.0140749557117keywords = count, spread (Clic here for more details about this article) |
5/48. mycoplasma pneumoniae non-pulmonary infection presenting with pharyngitis, polyarthritis and localized exanthem.We report a case of pharyngitis, polyarthritis and localized exanthem in acute mycoplasma pneumoniae infection not involving the lower respiratory tract. diagnosis was made by means of a particle agglutination test and IgM/IgG indirect immunofluorescence assay. This case describes a clinical complex never reported before and suggests the need for a high index of suspicion in cases of atypical presentation of M. pneumoniae infection.- - - - - - - - - - ranking = 0.0019960434153868keywords = assay (Clic here for more details about this article) |
6/48. Adverse cutaneous reaction to naproxen: a missed diagnosis fortuitously resolved.A 91-year-old man presented with a one-month history of swollen legs and dyspnoea. He also complained of a 16-year chronic rash that had caused him considerable morbidity and cosmetic problems. He had been taking naproxen for several years for osteoarthritis. Clinical examination demonstrated bilateral pitting oedema of the leg and a widespread excoriated rash that affected most of his body. A clinical diagnosis of fluid retention secondary to naproxen was made. Stopping naproxen led not only to the resolution of his leg oedema and dyspnoea, but also to the prompt and complete remission of the rash. Reviewing the patient's history revealed that the rash had almost certainly first appeared when naproxen was started many years previously.- - - - - - - - - - ranking = 0.014074955711682keywords = spread (Clic here for more details about this article) |
7/48. HHV-8- and EBV-associated nonepidermotrophic large B-cell lymphoma presenting as a foot rash in a man with AIDS.Human herpesvirus type 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus) is frequently identified in tumor tissue obtained from human immunodeficiency virus (hiv)-infected patients with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), or multicentric Castleman's disease. The association between HHV-8 and acquired immunodeficiency syndrome (AIDS)-associated solid lymphomas is less clear. Herein, I describe the case of a man with a CD4 count of 30 cells/microL, and hiv viral load of 90,000 copies/mL, multi-drug resistant hiv infection, and limited stage KS. biopsy of a progressive dorsal foot rash revealed a dense, deep, lymphoid infiltrate that extended into papillary dermis but without epidermotrophism. microscopy showed a homogeneous population of anaplastic large B cells that stained positive for CD20 (L26), CD30, and lambda light chain. in situ hybridization of tumor tissue identified Epstein-Barr virus (EBV)-encoded rna, and polymerase chain reaction amplification yielded HHV-8-specific gene products. Staging studies did not reveal lymphoma elsewhere, and the patient began chemotherapy, but died from septic complications. autopsy was notable only for the presence of a consolidative pneumonia. Although extranodal presentations are common in the setting of immunodeficiency, reports of AIDS-associated lymphoma presenting as a nonepidermotrophic foot lesion are rare. Such a presentation serves to broaden the differential of skin and foot lesions in the setting of hiv infection. More importantly, this case provides further support that HHV-8 can be associated with solid lymphomas that have an anaplastic large cell morphology.- - - - - - - - - - ranking = 1keywords = count (Clic here for more details about this article) |
8/48. Tula virus infection associated with fever and exanthema after a wild rodent bite.Reported here is the first case of human acute infection with Tula virus, which occurred in a 12-year-old boy in switzerland. This hantavirus had been considered apathogenic to humans, and in switzerland only TULV-genome sequences have been demonstrated in wild rodents to date. In this case, paronychia, fever and exanthema occurred after the patient was bitten by a wild rodent, indicating an unusual route of hantavirus transmission. Thus, Tula virus infection should be taken into account in patients with appropriate clinical symptoms and contact with rodents.- - - - - - - - - - ranking = 1keywords = count (Clic here for more details about this article) |
9/48. Acute allergic reaction following contact with a spider.Allergic reactions following contact or injury from arachnids are uncommon. There have previously only been reports of urticarial reactions following contact with large spiders from the family Theraphosidae. A 55-year-old male presented to hospital with a generalised urticarial rash following contact with a spider, identified by the person as a huntsman spider (family: Sparassidae). The spider had crawled over both his arms for a period of minutes. About 30 min later, he developed a rash on the arms which spread to the trunk. He then developed bradycardia and hypotension that required treatment with atropine, adrenaline and histamine antagonists. He recovered within 6 h and had no further problems. The early allergic reaction in this case was most likely the result of contact with the spider.- - - - - - - - - - ranking = 0.014074955711682keywords = spread (Clic here for more details about this article) |
10/48. Macular exanthema appearing 5 days after X-ray contrast medium administration.We report a case of widespread, pruritic macular exanthema appearing 5 days after intravenous administration of the X-ray contrast medium, iohexol (Omnipaque) in a patient who had not previously received any X-ray contrast medium. The eruptions resolved in 7 days, leaving no residual lesions. When the patient was challenged intradermally with the same contrast medium 1.5 months after recovery, the same type of eruption developed 1 day after challenge. Histological examination of biopsies from positive skin test sites revealed the presence of a dermal infiltrate of lymphocytes. This case is another example of a late-onset adverse reaction to an X-ray contrast medium, mediated by specific T cells. The usefulness of intradermal skin testing for confirming the allergic nature of the reaction and for studying cross-reactivity pattern is emphasized.- - - - - - - - - - ranking = 0.014074955711682keywords = spread (Clic here for more details about this article) |
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