1/16. The skin as the possible reservoir for candida albicans in the oculocutaneous candidiasis of heroin addicts.We describe 2 patients who injected themselves with the same brown heroin a few days before hospitalization. The first patient presented with characteristic oculo-cutaneous candidiasis. blood samples remained sterile during the so-called 'septicemic syndrome' which represents the first phase of this syndrome and were positive for candida albicans only when cutaneous nodules developed. The second patient was hospitalized for a stomach perforation and had no cutaneous or ocular candida involvement. Both patients were unusually colonized by C. albicans on their skin (particularly on hairy zones). These observations support the hypothesis that the skin may constitute the reservoir for C. albicans in oculo-cutaneous candidiasis.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
2/16. Breakthrough candida infection in a preterm infant with congenital cutaneous candida albicans infection.amphotericin b is the primary antifungal agent used for candida sepsis in neonates. Breakthrough candidemia was not reported in neonates during either amphotericin b or liposomal amphotericin b (AmBisome) treatment. We describe a case of a premature infant with congenital cutaneous candida infection, who had two episodes of breakthrough infection, from candida albicans and Candida parapsilosis, while he was treated with amphotericin b and AmBisome, respectively. We discuss the pathogenesis of breakthrough infections, and the relevance of antifungal resistance and sensitivities testing.- - - - - - - - - - ranking = 6keywords = candida (Clic here for more details about this article) |
3/16. A case of candidal umbilical granuloma.A case is reported of a 14-year-old boy with a mass arising from the umbilicus, which was a large, well-organized candidal granuloma. Cell markers showed normal numbers and distribution of peripheral T and B lymphocytes but there was no reaction to intradermal injection of Candida, suggesting a specific T-cell defect such as occurs in chronic mucocutaneous candidiasis.- - - - - - - - - - ranking = 5keywords = candida (Clic here for more details about this article) |
4/16. Early clinical recognition of disseminated candidiasis by muscle and skin biopsy.Disseminated candidiasis was clinically diagnosed by muscle and skin biopsies in two patients with hematologic malignancies. One patient with acute promyelocytic leukemia presented with skin lesions as the sole manifestation of disseminated candidiasis. The other patient had leukemic reticuloendotheliosis and developed fever, severe myalgias, and maculopapular rash while receiving corticosteroid therapy; this patient is the first to have antemortem documentation of candida myositis as the initial manifestation of disseminated candidiasis. These two case reports serve to emphasize the importance of careful observation and early biopsy of skin and muscle to establish the diagnosis and permit early institution of therapy.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
5/16. Primary cutaneous infections with candida species associated with percutaneous intravenous catheters in patients with cancer.Long-term percutaneous intravenous catheters have added greatly to the comfort of cancer patients who receive intensive therapy, but the resulting breach in body defenses contributes to infection. staphylococcus epidermidis has been a prominent infecting organism, and recently aspergillus species have been reported in association with Hickman lines. Two patients are reported with yeast infection: Candida parapsilosis with a Groshong catheter and candida albicans with a Hickman catheter. In immunocompromised patients such infections are potentially life-threatening and may reinforce the case for totally implanted venous access devices overlaid by intact skin.- - - - - - - - - - ranking = 4keywords = candida (Clic here for more details about this article) |
6/16. Candida chorioamnionitis diagnosed by amniocentesis with subsequent fetal infection.Isolation of candida albicans from the vaginal secretions of pregnant women occurs with an incidence of 5-23%. Intrauterine infection caused by Candida during pregnancy is relatively rare; only 81 cases, all diagnosed after delivery, have been reported. We report six cases of candidal chorioamnionitis diagnosed by amniocentesis and confirmed by histologic studies, associated with preterm labor and delivery of five viable infants. Three of the six maternal patients had intrauterine contraceptive devices in situ. Three infants had a diagnosis of congenital cutaneous candidiasis and two had congenital systemic candidiasis, one with monilial pneumonia, and one with meningitis and septicemia. All viable neonates were treated successfully. The sixth, a very immature infant, died soon after delivery. Torulopsis (Candida) glabrata was isolated from this amniotic fluid. C. Albicans is a pathogen that potentially may cause chorioamnionitis and has been associated with high mortality (94%) in infants weighing less than 1500 gm. Use of amniocentesis in patients with preterm labor may allow early detection of subclinical candidal chorioamnionitis, thus guiding appropriate perinatal management.- - - - - - - - - - ranking = 2keywords = candida (Clic here for more details about this article) |
7/16. Intrapleural inoculation of candida in an infant with congenital cutaneous candidiasis.Though several pathologic processes can produce large denuded skin lesions in very low birthweight infants, trauma is often diagnosed without further investigation. Failure to consider other causes may prevent institution of appropriate specific treatment and may contribute to the development of serious complications, as described in the present case report of a premature infant with congenital cutaneous candidiasis.- - - - - - - - - - ranking = 4keywords = candida (Clic here for more details about this article) |
8/16. Non-candidal infections in children with chronic mucocutaneous candidiasis.Chronic mucocutaneous candidiasis (CMCC) is a clinical syndrome characterized by persistent and recurrent candida albicans infections of the mucous membranes and skin often associated with immunodeficiency. In order to gain insight into the frequency and severity of non-candidal infections in children with CMCC, four patients with CMCC are described in detail and 60 previously reported cases are reviewed. Fifty percent of children with CMCC had significant infections with other fungi, bacteria and viruses. Recurrent bacterial pneumonias and bronchiectasis were a major cause of morbidity and mortality. In addition, there were a large number of infections, in both the lung and other sites, due to opportunistic organisms. Thus the clincial syndrome of CMCC includes not only mucocutaneous candidiasis, endocrine failure and autoimmune phenomena, but patients with CMCC also show a remarkable susceptibility to non-candidal infections. These non-candidal infections represent a serious cause of morbidity for patients with CMCC.- - - - - - - - - - ranking = 7keywords = candida (Clic here for more details about this article) |
9/16. Systemic candidiasis: diagnosis from cutaneous manifestations.Three patients are described who developed systemic candidiasis. Each had either leukaemia or lymphoma, and developed a similar erythematous maculopapular rash which, in places, was purpuric. In the first patient the nature of the rash was not appreciated during life, but postmortem histology revealed candida within the lesions. In the other two patients, a diagnosis of systemic candidiasis was successfully established by skin biopsy. This paper emphasizes that a maculopapular rash can be relatively characteristic clinical manifestation of systemic candidiasis and that skin biopsy can be diagnostic.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
10/16. Oral fluconazole treatment of fungating candidiasis in the keratitis, ichthyosis and deafness (KID) syndrome.We report a patient with a congenital ichthyosiform eruption, sensorineural deafness, vascularizing keratitis and pannus formation, and hypotrichosis, who developed recalcitrant fungating candidal plaques on the skin. There was no family history of similar disease, or of consanguinity. The steroid sulphatase level in the keratin was within normal limits, and this finding excluded a diagnosis of X-linked recessive ichthyosis. Treatment with oral fluconazole for 14 weeks resulted in complete resolution of the fungating lesions, and there has been no evidence of recurrence during a 12-month follow-up period.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
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