1/22. Dysembryoplastic neuroepithelial tumor. A case report.Dysembryoplastic neuroepithelial tumor (DNT) is a rare, benign tumor encountered in the cortex. It is characterized by the presence of cells of different histogenesis. Due to its mixed nature (glial-neuronal), WHO histological classification of brain tumors included it into the group of neuronal and glial-neuronal mixed tumors. Case of tumor in a 19-year-old woman experiencing for three years seizure of temporal lobe epilepsy is presented. A cranial magnetic resonance imaging (MRI) showed "pseudocystic" tumor in temporal lobe. Histological and immunocytochemical examinations of the tumor fragment removed during surgery revealed large numbers of neuronalglial nodules occurring in the cerebral cortex. Columns of glial-neuronal structures crossing parallely to the cortex surface, surrounded by oligodendrocyte-like cells (OLC) were a characteristic feature of the tumor texture. In the tumor interstitium, "floating" maturated, dysplastic-free ganglionic cells were visible in numerous bright spaces. In addition, numerous lobuliform--structured areas consisted of oligodendrocyte-like cells. Oligodendrocyte-like cells were characterized by positive immunoreaction to the presence of S-100 protein and synaptophysin. Basing on clinical manifestation and histopathological findings dysembryoplastic neuroepithelial tumor was diagnosed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/22. Laparoscopic cystectomy of a twisted, benign, ovarian teratoma in the first trimester of pregnancy.Adnexal torsion is an unusual, but serious complication in pregnancy. The treatment is surgical, but this may increase the risk of pregnancy loss in the first trimester. The use of laparoscopic surgery, which is less invasive than traditional laparotomy, has been limited by diagnostic and technical difficulties including determination of ovarian tumor nature and spillage of cyst contents intraoperatively. A 25-year-old woman in her 11th week of pregnancy had acute severe left lower-abdominal pain, which was diagnosed as left ovarian teratoma with torsion. She underwent emergency laparoscopic surgery with unwinding of the twisted fallopian tube and ovary and cystectomy of the teratoma. The patient subsequently delivered a full-term baby, without complications. Accurate ultrasound and cytologic diagnoses along with copious intraoperative warm, normal saline irrigation were likely contributing factors to the successful outcome of this case.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/22. Androgen-secreting adrenal adenomas.BACKGROUND: The androgen source in women with hirsutism and signs of virilism may be the ovary or adrenal gland. CASES: Three patients with androgen excess are reported. Two had hyperandrogenemia and cushing syndrome with an adrenal mass greater than 5.5 cm; the third had a small adrenal adenoma secreting only testosterone and responsive to human chorionic gonadotropin. In all cases, the pathologic report from surgery and the long-term resolution of symptoms confirmed the benign nature of the tumors. CONCLUSION: Basal and dynamic hormonal tests cannot precisely differentiate ovarian from adrenal tumors. Adrenal adenomas must be considered as a cause of hyperandrogenic syndrome.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/22. Lacrimal gland tumors in a medical center.Between 1971-2001, there were 9 cases of lacrimal gland tumors in the hospital medical records, 3 adenocystic carcinomas, 1 adenosquamous, 3 benign mixed tumors and 2 malignant mixed tumors. Only 4 had complete clinical histories: 1 benign mixed tumor and 3 adenocystic carcinomas. Among the 4 patients, 3 of them had the tumors removed by transeptal techniques and only I had complete removal of the tumor in a single mass. The histopathology proved to be a benign mixed tumor and was completely cured. The other 2 were adenocystic carcinomas which could not be completely removed, resulting in recurrences of the tumors and distant metastases. Both of them died from intracranial extensions. In 1 case of adenocystic carcinoma, the tumor was removed easier by the lateral orbitotomy technique. The nature of this kind of tumor must be known for accurate diagnosis, proper plan of the management and prognosis of the patient.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/22. paclitaxel and carboplatin chemotherapy administered during pregnancy for advanced epithelial ovarian cancer.BACKGROUND: Ovarian cancer diagnosed during pregnancy is uncommon. Most chemotherapy use reported has been in combination with cisplatinum. paclitaxel in combination with carboplatin during pregnancy has not yet been reported. CASE: A right adnexal mass was diagnosed during pregnancy at 5 weeks' gestational age in a 30-year-old woman. A laparotomy was performed 2 1/2 weeks later because of the worsening nature of her symptoms and the possibility of ovarian torsion. At surgery, the patient was diagnosed with stage IIIC ovarian papillary serous cystadenocarcinoma. She was treated with six cycles of paclitaxel and carboplatin beginning at 16-17 weeks' gestation. At 35.5 weeks' gestation, a cesarean hysterectomy, left salpingo-oophorectomy, and pelvic and paraaortic nodal sampling with multiple peritoneal biopsies was performed without incident. However, the patient had refractory disease present in the remaining ovary. She was treated with further chemotherapy and is currently doing well. The patient experienced no adverse reactions during her treatment, and the infant has normal growth and development at 15 months of age. CONCLUSION: paclitaxel used in combination with carboplatin for the treatment of ovarian cancer during pregnancy caused no adverse effects in the infant.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/22. Acute leukemia in pregnancy with ovarian metastasis: a case report and review of the literature.Acute leukemias tend to affect a younger population and are much more common in pregnant patients than chronic leukemias are. We report a case of acute lymphoblastic leukemia diagnosed during the third trimester presenting with organomegaly and thrombocytopenia. Delivery of the fetus by cesarean section was decided because of the fulminant nature of the acute leukemia within days of admission. bone marrow biopsy revealed acute lymphocytic leukemia, French American-British L2 subtype B cell immunotype. A left ovarian mass was identified during the cesarean section which later proved to be lymphoblastic infiltration. The patient was started on induction chemotherapy consisting of vincristine, daunorubicin, prednisolone, and l-asparaginase immediately after the diagnosis. The patient died of acinetobacter septicemia 18 days after the first admission.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/22. Coexisting brenner tumor and struma ovarii in the right ovary: case report and review of the literature.A bilateral ovarian tumor composed of mixed brenner tumor and struma ovarii in the right ovary and mature cystic teratoma in the left ovary, is described. Mixed brenner tumor and struma ovarii is rare; eight cases are reviewed. In this case, in addition to the typical brenner tumor and struma ovarii, some nests composed of both brenner tumor and struma ovarii in one nest were found in the right ovarian tumor. Immunohistochemically, the struma ovarii is stained for thyroglobulin, and Brenner nests showed various degrees of positive stain for thyroglobulin, which is a specific finding. brenner tumor, in this case, may produce thyroglobulin or have a receptor to thyroglobulin or analog of thyroglobulin. The origin of mixed brenner tumor and struma ovarii may be germ cell, as described in some literature, or the brenner tumor may be of a metaplastic nature, although the brenner tumor is fourfold the size of struma ovarii in the case presented.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/22. Fibrous histiocytoma-like Spindle-cell proliferation in the Nipple After Body-Piercing.We report the case of a 19-year-old pregnant woman who presented with a nipple tumor. The lesion consisted in a spindle-cell proliferation with histologic features similar to those of fibrous histiocytoma, with a highly vascularized stroma. Although it showed low mitotic activity, scattered marked atypical cells with prominent nucleoli were identified, thus raising concern about the benign nature of the tumor. Immunohistochemical evaluation revealed that the spindle cells were diffusely positive for vimentin, focally positive for CD68, and negative for all the other tested antibodies. The patient had a total excision of the lesion and she is free of disease after 30 months. To our knowledge this is the first reported case of a lesion of this type in the nipple after body-piercing.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
9/22. Fibroepithelial polyps of the vagina in pregnancy.A 38-year old pregnant woman presented with a polypoid tumor of the vagina. A biopsy revealed benign fibroepithelial polyps. Her pregnancy progressed normally, and she underwent an uncomplicated vaginal delivery. Once the benign nature of the lesion has been established, a spontaneous vaginal delivery is not contraindicated. However, operative vaginal delivery should be avoided to reduce the risk of trauma and hemorrhage. Local excision is curative and may be performed as an interval procedure when the vaginal vascularity has returned to normal.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
10/22. Conservative management of an ovarian cyst in late pregnancy.We report a case of concomitant ovarian tumor and pregnancy. Sonographic examination indicated that the tumor was benign and obstructed the birth canal. After conservative treatment (puncture of the cyst), a normal vaginal delivery was possible. Two days after delivery, salpingo-oophorectomy was performed because of torsion of the cyst. Pathological examination confirmed the benign nature of the cyst.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
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