1/23. Primary omental liposarcoma presenting with torsion: a case report.An 83 year-old man was admitted because of abdominal pain and distention. A mass measuring 20x10 cm and associated with tenderness and guarding was palpable in the right lower abdomen. ultrasonography and computed tomography showed a tumor with solid and multiple cystic areas. Celiac angiography showed slight tumor vascularity fed by the right gastroepiploic artery. A malignant tumor of the omentum was suspected. At laparotomy, torsion of the omental pedicle of the tumor was found. Histological examination of the resected tumor revealed characteristics of round-cell liposarcoma, which usually has a poor prognosis. The patient has been alive and well for 2 years. Primary liposarcoma of the omentum has been reported in only seven previous cases. None of these patients presented with torsion, and no report has thus far included a documented survival.- - - - - - - - - - ranking = 1keywords = liposarcoma (Clic here for more details about this article) |
2/23. Recurrent liposarcomas of the abdomen and retroperitoneum: three case reports.We report three cases of patients with liposarcomas of the abdomen who had been treated during the last 13 years (1980-1993). Two patients were men, aged 29 and 51 years, with tumors of the retroperitoneal space and the third patient was a woman aged 64 years with a tumor in the peritoneal cavity. Therapeutic treatment was as aggressive as possible excision of the tumor. In the case of the first male patient, the histological examination revealed a retroperitoneal myxoid liposarcoma which recurred 5 times within 13 years. In the second male patient, it revealed a well differentiated retroperitoneal liposarcoma of the sclerosing type which recurred 5 times within 5 years since the first treatment. Finally, the one female patient had 2 recurrences of myxoid liposarcoma of the abdomen 9 years after the first operation, presented with an infected mass and has been well since then.- - - - - - - - - - ranking = 1.3333333333333keywords = liposarcoma (Clic here for more details about this article) |
3/23. Morphologic-cytogenetic analysis of dedifferentiated liposarcomas with an extensive misleading leiomyosarcomatous component.This report describes two cases of recurrent retroperitoneal dedifferentiated liposarcoma characterized by an extensive leiomyomatous component that prevented the correct diagnosis before the last recurrence. Strong immunoreactivity with smooth muscle and desmin antibodies and ultrastructural features consistent with leiomyosarcoma were observed in the spindle-cell and/or myxoid-like components in all four recurrences in case 1, and in the spindle-cell component of the primary tumor and the first recurrence in case 2. In case 1, the correct diagnosis was suggested by the cytogenetic evidence of ring markers, a hallmark of well-differentiated/dedifferentiated liposarcoma. In case 2, tumor type was yielded mainly by the morphology of the second recurrence, which consisted entirely of a well-differentiated liposarcoma, a sclerosing inflammatory variant, as confirmed by the karyotype. Reevaluation of the first two surgical specimens of each case revealed small areas consistent with well-differentiated liposarcoma that had been previously overlooked. Despite the smooth-muscle antigen profile, both cases retained an mdm2 /p53 /cdk4 immunophenotype consistent with the genotype.- - - - - - - - - - ranking = 1.4281283628079keywords = liposarcoma, dedifferentiated (Clic here for more details about this article) |
4/23. Primitive round cell liposarcoma of the omentum: diagnostic value of ultrastructural study.A 25-year-old woman presented with abdominal distension first observed 1 month earlier. She had a rapidly growing omental tumor that was eventually diagnosed as round cell liposarcoma by ultrastructural examination. This case illustrates the importance of ultrastructural study and the limitations of immunohistochemistry in the diagnosis of such tumors, particularly when they grow in unusual locations.- - - - - - - - - - ranking = 0.83333333333333keywords = liposarcoma (Clic here for more details about this article) |
5/23. Primary liposarcoma of the omentum: a case report and review of the literature.A case of round cell liposarcoma of omentum in a 45-year-old man is reported. The patient presented with abdominal pain, swelling and fever of 4-month duration. Abdominal ultrasonography and computed tomogram confirmed the presence of an abdominal mass, but the omental origin of the tumour was revealed only on laparotomy. In addition to the main tumour mass, multiple nodules were present in the omentum. The tumour was excised with omentum. Histopathology of the tumour revealed a round cell liposarcoma. The patient expired 9 months after operation. Eight other cases of liposarcoma of omentum reported in English literature are reviewed.- - - - - - - - - - ranking = 1.1666666666667keywords = liposarcoma (Clic here for more details about this article) |
6/23. Primary omental liposarcoma presenting as an incarcerated inguinal hernia.Herein, we present a case of primary liposarcoma of the omentum found in an incarcerated inguinal hernia in a 52-year-old male patient. The patient was admitted to our hospital in June 2000 with sudden onset of left-sided abdominal and groin pain of 12 hours' duration with a large, irreducible inguinal hernia. This was not associated with nausea or vomiting. An emergency operation was performed, and in the hernia sac the tumor, arising from the greater omentum, was found. After we opened the transversal fascia and peritoneum, the tumor was resected with a block of the greater omentum, and hernioplasty was performed using Shouldice's method. The histopathological diagnosis of resected tumor showed myxoid type liposarcoma. In the English medical literature, omental liposarcoma has never before been reported as the content of a hernia sac.- - - - - - - - - - ranking = 1.1666666666667keywords = liposarcoma (Clic here for more details about this article) |
7/23. Primary round cell liposarcoma of the omentum. A case report.Liposarcomas are the most common of the malignant soft tissue tumors arising in the mediastinum and retroperitoneum. We have treated patients for round cell liposarcoma, an unusual histologic subtype, which is reported to be histologically mistaken for Ewing's sarcoma, lymphoma and other round cell neoplasms. The successful resection of a 2,300-g round cell liposarcoma of the omentum was recently performed at our hospital. Ultrastructural observations of this tumor are characterized by massive proliferation of the mitochondria in addition to the presence of lipid vacuoles in tumor cells. To our knowledge, no description of substantial mitochondrial proliferation in round cell liposarcoma has appeared previously in the literature; therefore, this is the first case report of histopathologic, cytopathologic and electron microscopic observations on this extremely rare tumor.- - - - - - - - - - ranking = 1.1666666666667keywords = liposarcoma (Clic here for more details about this article) |
8/23. Hepatoid malignancy of unknown origin--a diagnostic conundrum: review of literature and case report of collision with adenocarcinoma.Hepatoid carcinomas are a group of neoplasms with features resembling hepatocellular carcinomas. Although rare, more cases have been noted to arise from various organs within the last decade. Differentiating these tumors is not only a challenge but also critical, since treatment modalities and operative strategies are dependent upon the exact nature of the hepatoid cancer. Based on a review of literature, we discuss the guidelines for differentiating these tumors and utilize these criteria to differentiate these tumors irrespective of their primary tissue of origin. We also describe an unusual case of hepatoid variant of primary peritoneal yolk sac tumor presenting with extensive carcinomatosis and as a collision with two synchronous primary colonic adenocarcinomas, neither of which has been reported to our knowledge to date, thereby falsely mimicking metastatic dedifferentiated colonic adenocarcinoma. CASE DESCRIPTION: A septuagenarian female presented with weight loss, chronic anemia and ascites associated with bloating. Her past history was significant for COPD, hysterectomy and a bilateral oophorectomy 40 years previously. A work up which included computed tomography (CT) and contrast enema revealed significant ascites with multiple peritoneal nodules causing ascending colonic obstruction. Celiotomy revealed the entire peritoneal surface to be studded with nodules, with the largest measuring 6.0 cm. Intraoperative ultrasound, prompted by the frozen section of nodules resembling liver tissue, revealed no intrahepatic nodules. Right colectomy, omentectomy and tumor debulking were performed. The postoperative course was uneventful except for ascitic leak that spontaneously resolved. DISCUSSION: The peritoneal nodules consisted of malignant cells arranged in cords that resembled liver tissue. In the absence of a primary identifiable liver disease, this is consistent with either hepatoid variant of primary yolk sac tumor or hepatoid carcinoma arising from the peritoneum. The right colectomy specimen revealed two mucosal ulcers consistent with colonic adenocarcinoma abutting two large tumor nodules on the serosal surface. Although grossly appearing to be contiguous, low power examination showed that the serosal nodule and the mucosal lesion were entirely different, and separated by a definite fibrous band. Immunohistochemical stains and patterns were used to differentiate the type of tumor. This article also discusses the criteria used to differentiate hepatoid yolk sac tumors (hepatoid-YSTs), hepatoid carcinomas and metastatic hepatocellular carcinomas and the phenomenon of opisthoplasia observed in certain malignancies. The difficulties encountered in identifying hepatoid carcinomas and current modalities used to differentiate these tumors are highlighted. The phenomenon of opisthoplasia and the challenges posed by this phenomenon in certain metastatic lesions are reviewed and explanations for the possible origins of hepatoid tumors are considered. CONCLUSION: The most likely explanation in our case is that the hepatoid tumor either originated from microscopic remnant ovarian tissue left behind or primarily from the peritoneum. With no evidence of yolk sac component within the colonic tumor or in the draining lymphatics, this essentially excludes the commonly observed metastatic dedifferentiation (opisthoplasia) of adenocarcinoma to primitive forms (also known as combination tumors). Based on analysis of various factors, including tumor behavior and response to chemotherapy, we conclude that our case was a hepatoid variant of yolk sac tumor presenting in an elderly woman with carcinomatosis. This unusual presentation of two entirely different primary malignancies in close proximity is defined as "collision tumor". This is the first reported case of collision tumors involving dual colonic and primary peritoneal hepatoid-YST. Identifying the exact type still remains to be the most challenging aspect in the diagnosis of hepatoid tumors.- - - - - - - - - - ranking = 0.01579917157909keywords = dedifferentiated (Clic here for more details about this article) |
9/23. Metastatic myxoid liposarcoma in the mesentery: what is debated? Case report and a review of the literature.Myxoid liposarcoma, unlike other types of liposarcoma, has an unusual propensity to metastasize to extrapulmonary sites including the abdominal cavity. Metastatic myxoid liposarcoma is an important condition because it may indicate distant micrometastatic disease. We report the case of a 47-year-old woman with a metastatic myxoid liposarcoma in the mesentery. Surgical excision with a tumor-free margin was achieved, but cardiac and liver metastases developed. We review the available literature and discuss what is still debated about this disease.- - - - - - - - - - ranking = 1.3333333333333keywords = liposarcoma (Clic here for more details about this article) |
10/23. Primary mesenteric liposarcoma of jejunum: presentation like a cystic mass.This report describes a rare case of intra-abdominal liposarcoma in a 67-year-old woman. The patient presented at internal medicine Unit in May 2004, to study of thyroid pathology. The clinical examination was normal, except for the finding of an asymptomatic mass in the abdomen. The patient knew the existence of tumor since time ago, but she confesses to have only occasional discomfort. In the abdominal ultrasonography a solid mass with large cystic component was detected but relation with other organs was not clear. Computed tomography revealed the presence of a mass with solid and cystic components, in contact with small intestine in the left side of abdomen. A complete resection of tumor arising from mesentery of jejunum was performed successfully with end to end anastomosis. The gross specimen was lobulated and measured 8.5 x 7.5 cm. The histopathology analysis showed proliferating lipoblasts with irregular nuclei on a myxoid background, with plexiform vascular pattern, characteristics belongs to myxoid type liposarcoma. The patient is alive and well one year after removal of tumor. The uncommon site and the exceptional cystic morphology of tumor are discussed, and so it must be included the primary mesenteric liposarcoma in the differential diagnosis of intra-abdominal tumors with cystic large areas.- - - - - - - - - - ranking = 1.1666666666667keywords = liposarcoma (Clic here for more details about this article) |
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