1/22. Human herpes-virus 8 seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation.Kaposi's sarcoma (KS) has been reported after solid organ transplantation mostly in recipients of renal, liver, heart, and bone allografts. We describe the first case of a patient with lung transplantation who developed KS of the skin, but also of the lung graft. The tumors were localized to places of previous trauma, implying the involvement of a Koebner phenomenon. Moreover, a polymerase chain reaction assay revealed the presence of dna sequences of herpesvirus 8 (HHV-8) on tissue of the cutaneous KS. Serological tests showed HHV-8 seronegativity of the graft donor and HHV-8 seropositivity of the patient before lung transplantation suggesting that the latter was already infected before the surgery and that immunosuppression resulted in the development of KS. This case report raises the question of the prevalence of HHV-8 in candidates for transplantation and organ donors, and of the value of an antiviral prophylaxis to lower the risk of KS.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
2/22. adult herpetic laryngitis with concurrent candidal infection: a case report and literature review.Rarely, adult herpetic laryngitis without involvement of the oropharynx has been reported. However, to our knowledge, laryngitis caused by herpes simplex virus with coexisting candida albicans has not been reported. We report what we believe to be the first case of localized herpetic laryngitis superimposed by laryngeal Candida species infection in an immunosuppressed patient. This diagnosis was made on the basis of the findings of a laryngeal mucosal biopsy and ancillary testing using fungal stains and immunohistochemical stains for herpetic antigens. We also review the literature and discuss the clinical and diagnostic presentations, including potential pitfalls in the diagnosis.- - - - - - - - - - ranking = 4keywords = candida (Clic here for more details about this article) |
3/22. cunninghamella infection post bone marrow transplant: case report and review of the literature.cunninghamella spp., in the class Zygomycete and order mucorales, are unusual opportunistic pathogens that have been identified with increased frequency in immunocompromised patients. Infections with this group of organisms have been seen most frequently in patients with hematologic malignancy. We describe an allogeneic bone marrow recipient who developed fungal pneumonitis and disseminated fungal dermatitis caused by cunninghamella spp. To our knowledge, this is the first reported case of cunninghamella infection in a BMT recipient. The case highlights the mortality associated with opportunistic infections in immunocompromised patients and confirms the risk factors associated with non-candida fungal infections after bone marrow transplantation.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
4/22. When candida turns deadly.Thrush, diaper rash, and vaginal yeast infection are all common manifestations of candida. But for the immunocompromised patient, this common fungal species can cause a host of problems, including life-threatening infections.- - - - - - - - - - ranking = 5keywords = candida (Clic here for more details about this article) |
5/22. osteomyelitis caused by mycobacterium haemophilum: successful therapy in two patients with AIDS.OBJECTIVE: Difficulties involved in diagnosis and response to antimicrobial therapy are described in detail for two cases of biopsy-proven osteomyelitis caused by mycobacterium haemophilum in AIDS patients. SETTING: Two large, private teaching hospitals in new york city, New York, USA. patients, PARTICIPANTS: A 31-year-old woman with previous diagnoses of candida esophagitis and peripheral neuropathy (patient 1), and a 37-year-old man with Kaposi's sarcoma (patient 2). INTERVENTIONS: One patient was treated with a combination of rifampin, ethambutol, clofazimine, and ciprofloxacin, while the other received rifampin, ciprofloxacin and doxycycline. Both patients also received a short course of intravenous amikacin. MAIN OUTCOME MEASURES: disease activity was monitored clinically by observing resolution of skin ulcers, lymphadenopathy, and pain and swelling in areas affected by osteomyelitis. RESULTS: Both patients experienced complete resolution of signs and symptoms of M. haemophilum infection. Patient 1 was treated for 17 months and remains well after 10 months without therapy. Patient 2 shows no evidence of infection after 14 months of therapy. CONCLUSIONS: M. haemophilum infection must be considered in the differential diagnosis of osteomyelitis in AIDS patients, although specialized culture techniques are required to isolate and identify this pathogen. Excellent clinical response can be achieved with oral antimicrobial therapy.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
6/22. cunninghamella bertholletiae infection (mucormycosis) in a patient with acute T-cell lymphoblastic leukemia.cunninghamella spp. are unusual opportunistic pathogens that have been identified with increased frequency in immunocompromised patients. Clinical infection by this fungus is almost always devastating and usually fatal. Infections with this group of organisms have been seen most frequently in patients with hematological malignancy. Here we report the case of a patient with acute leukemia who developed multiorganic failure as a consequence of hematological dissemination by cunninghamella bertholletiae. The case highlights the mortality associated with this fungal infection in immunocompromised patients, confirms the risk factors associated with non-candida fungal infections and shows a clinical presentation mimicking myocardial infarct and cerebrovascular stroke.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
7/22. Disseminated tuberculosis complicating anti-TNF-alpha treatment.An unusually large number of cases of tuberculosis, often of miliary or disseminated form, have been reported in patients receiving infliximab therapy for rheumatoid arthritis or Crohn's disease. We describe a patient with rheumatoid arthritis who was treated with infliximab and became systemically ill with mycobacterium tuberculosis-disseminated infection. patients who are candidates for treatment with tumour necrosis factor-alfa inhibitors should be evaluated for the presence of latent or active- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
8/22. Bilateral chronic fungal dacryocystitis caused by Candida dubliniensis in a neutropenic patient.In recent years, candida species other than candida albicans have emerged as causes of human candidiasis, particularly in hiv-infected and other immunocompromised people. C. dubliniensis, a recently described species closely related to C. albicans, first isolated from patients with AIDS in Dublin, has been implicated as an agent of oral candidiasis in hiv-positive people. However, it has also been recovered from hiv-negative people, with clinical signs of oral candidiasis and from the genital tract of some women with vaginitis. The first case of bilateral chronic fungal dacryocystitis caused by C. dubliniensis is described in an hiv-negative woman.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
9/22. Transient fungaemia due to Candida pelliculosa in a patient with AIDS.Candida pelliculosa Redaelli (syn. Hansenula anomala) was isolated from blood cultures of a patient with acquired immunodeficiency syndrome. The transient candidaemia was apparently associated with intravenous drug addiction. The isolate was identified by standard methods such as API 20 C Aux and 16 discs carbon auxanogram. The isolate was sensitive to amphotericin b, 5-fluorocytosine and ketoconazole. This organism adds to the growing list of Candida species associated with acquired immunodeficiency syndrome.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
10/22. Candidal oesophagitis in Cushing's syndrome.opportunistic infections are known to occur with increased frequency in patients with Cushing's syndrome, particularly those due to ectopic ACTH production. This report highlights the rare situation of a patient with Cushing's disease having candidal oesophagitis as one of the major presenting manifestations.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
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