1/10. indocyanine green angiography of optic nerve head melanocytoma.PURPOSE: To determine the features of fluorescein and indocyanine green angiography of melanocytoma. methods: Fluorescein and indocyanine green angiography is used to assess an optic nerve head melanocytoma in a 45-year-old female. RESULTS: fluorescein angiography revealed increased vascularity on the surface, with staining around the lesion in the late stages. The lesion was hypofluorescent in all stages of indocyanine green angiography. CONCLUSIONS: indocyanine green angiography is helpful in identifying the benign nature of the lesion by showing hypofluorescence, indicating lack of vascularity in the tumor.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/10. Broad spectrum of leukoderma acquisitum centrifugum.A series of diverse neuroectodermally derived tumors associated with halos of leukoderma is presented. Clinically these lesions have in common a centrally placed, usually pigmented tumor encircled by a zone of hypopigmentation. The histological findings include (1) reduction or absence of epidermal melanin, but persistence of amelanotic melanocytes in the leukodermic halo; (2) a variety of tumors including nevus-cell nevus, neuroid nevus, blue nevus, neurofibroma, and malignant melanoma; (3) variable numbers of "small dark cells" whose nature is unclear, and which probably represent in part small nevus cells and in part lymphoid cells; and (4) damage to some tumor cells which presumably could be the cause of their destruction. Also presented are histochemical demonstrations of tyrosinase activity and immunohistochemical studies for presence of gamma-globulin in the tumors. Using the fluorescent antibody technique it was not possible to show gamma-globulins in patients' sera directed against their tumors. The relationship of developing hypopigmentation to the spontaneous regression of cutaneous neuroectodermally derived tumors is discussed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/10. A case of bathing trunk nevus studded with neurofibroma-like papules.There is a significant association between bathing trunk nevus and neurofibromatosis. However, not all neurofibroma-like papules detected clinically in cases with bathing trunk nevus may be a neurofibromas and histopathological confirmation is essential for definition of these lesions. We report a 21 year old white male patient with a bathing trunk nevus studded with neurofibroma-like papules of melanocytic nature. Histopathological examination of both papular and flat lesions showed diffuse melanocytes with plentiful eosinophilic cytoplasm and round nuclei in the dermis. immunohistochemistry showed strong positivity of dermal melanocytes for S-100 protein. The clinical and histopathological findings and positivity of dermal melanocytes for S-100 protein were consistent with bathing trunk melanocytic nevus.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/10. Spinal arachnoid cyst containing nevus cells in a patient with a large congenital melanocytic nevus: case report.OBJECTIVE AND IMPORTANCE: Spinal arachnoid cysts are rare, and their cause and pathogenesis remain controversial. We experienced a rare case with a large congenital melanocytic nevus in which a spinal arachnoid cyst contained nevus cells, suggesting the congenital nature of a spinal arachnoid cyst.CLINICAL PRESENTATION: A 37-year-old Japanese man had been born with a large melanocytic nevus on his back. He experienced intermittent pain radiating to both thighs and to the lower back and waist. A magnetic resonance imaging study disclosed the presence of a posterior intradural extramedullary arachnoid cyst extending from T10 through T12. His spinal cord was displaced anteriorly and flattened.INTERVENTION: An osteoplastic laminoplasty was performed, and the arachnoid cyst was totally removed. The cyst membrane exhibited many foci of brown deposits, and histological examination disclosed the presence of melanin-containing cells in the cyst membrane. Morphologically and immunohistochemically, the melanin-containing cells in the cyst membrane were similar to nevus cells in the dermis.CONCLUSION: The histological findings of our case suggest that the patient's spinal arachnoid cyst was formed at the same stage of development as the melanocytic nevus.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/10. Nevus sebaceus, syringocystadenoma papilliferum, and basal cell epithelioma.This case report illustrates the pluripotential nature of the hair matrix cells in nevus sebaceus. Syringocystadenoma papilliferum and basal cell epithelioma both developed in the same scalp lesion. The staged surgical excision is illustrated.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/10. White corrugated mucosa.A patient with white sponge nevus involving the buccal mucosa, labial mucosa, and soft palate is reported. The salient clinical and histological features of the disease were discussed. This diagnosis should be considered when bilateral white lesions of buccal mucosa are encountered. Early onset, a familial history, and the asymptomatic nature are key features to the disease. If historical data and clinical features are suspect, an incisional biopsy is adequate for diagnosis.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/10. Benign nevus cells in the lymph nodes. An immunohistochemical study.Aggregates of nevus cells in the axillary lymph nodes may give rise to a suspicion of metastatic breast cancer. Usually the nevus cells are confined to the capsule or the trabeculae, but in the present case, clusters of nevus cells were also observed in the peripheral sinus. Immunohistochemical analysis for S-100 protein and epithelial membrane antigen established the true nature of the cells.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/10. Porokeratotic eccrine ostial and dermal duct nevus.Comedo-like lesions of the palm, present since birth, are studied electronmicroscopically and their eccrine nature demonstrated. We suggest their inclusion under the name porokeratotic eccrine-ostial and dermal duct nevus previously proposed by Abell and Read.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
9/10. 7. Pseudometastatic lesions of the choroid.A 64-year-old man with a six-month history of visual loss was found to have multiple darkly pigmented lesions scattered throughout the choroid of both eyes. Some lesions, up to several disc diameters in size, were flat, but others were elevated one to two millimeters. The right eye also contained a darkly pigmented ciliary body mass. Impairment of light transmission was striking. ultrasonography of the elevated lesions demonstrated solid masses with high internal reflectivity. The initial diagnostic differential included the possibility of pigmented metastases from a primary tumor elsewhere, as well as multiple primary nevi. A general medical examination demonstrated arteriosclerotic heart disease, hypertension, diabetes mellitus, areas of patchy pigmentation of the oral mucosa, and a hilar prominence. A mediastinal lymph node biopsy specimen showed a grade 3 undifferentiated carcinoma compatible with a lung primary carcinoma. Enlargement of the choroidal lesions was observed until the patient's death 15 months later. autopsy showed an undifferentiated carcinoma of the lung with widespread metastases. Each eye showed multiple discrete benign melanocytomas within a diffuse nevus involving the entire uveal tract. The nature of the relationship between multiple uveal melanocytomas and the systemic carcinoma is uncertain, but recognition of multiple uveal melanocytomas warrants a general medical examination to exclude primary malignancy elsewhere.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
10/10. Recurrent multiple pyogenic granuloma with multiple satellites. Features of Masson's hemangioma.The case of a thirteen year old white girl who had multiple recurrences of pyogenic granuloma arranged in a satellite fashion is presented. The incidence and frequency of pyogenic granuloma with or without recurrences is discussed, stressing the unusual nature of the present problem. In addition to the microscopic features of pyogenic granuloma, the changes seen in Masson's hemangioma were demonstrable in some of the sections. The microscopic distinguishing feature of Masson's hemangioma is discussed, with emphasis on the importance of recognizing this as a benign structure rather than a malignant one. Opinions concerning the etiology of pyogenic granuloma as well as the reasons for the development of multiple satellites are presented, along with suggestions for therapy.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
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