1/17. Visceral and cutaneous leishmaniasis (report of 2 cases).leishmaniasis is an endemic, sporadic infection in many parts of the world. turkey is geographically unique in linking asia and europe. Of special interest is leishmaniasis, as various forms of this disease have long been reported in the surrounding regions. Visceral and cutaneous leishmaniasis are endemic in the western and southeastern parts of turkey, respectively. Here, we report a cutaneous and a visceral leishmaniasis case, to draw attention to the increase in the incidence of leishmaniasis in turkey. In the patient with cutaneous leishmaniasis, the ulcerative lesion on the cheek had persisted for two months before admittance to the hospital. Direct smears prepared from this lesion were negative for leishmania amastigotes whereas the promastigote forms were maintained in NNN (Novy-MacNeal-Nicolle) medium. The second patient was hospitalized with a prediagnosis of haematological malignancy, but the smears prepared from the bone marrow aspirates revealed leishmania amastigotes and promastigotes were seen on the smears from NNN cultures. These two reports mark the importance of inoculation of the specimens to NNN medium for the recovery of the promastigote forms. Cutaneous and visceral leishmaniasis have become endemic in considerable number of foci in turkey, possibly due to the cessation of vector control programmes and increase in the agricultural and irrigation areas. These two reports also point out the increased prevalence of leishmaniasis in turkey after 1980's.- - - - - - - - - - ranking = 1keywords = world (Clic here for more details about this article) |
2/17. leishmania donovani invasion of the blood in a child with dermal leishmaniasis.Cutaneous leishmaniasis is highly endemic in eastern Mediterranean countries. The causative organisms are leishmania tropica or leishmania major but, further west, variants of leishmania infantum frequently cause cutaneous leishmaniasis. We report a young girl from Beirut with an acute cutaneous leishmaniasis in whom the causative organism was cultured from both the skin lesion and the blood in the absence of any signs or symptoms typical of systemic involvement. The parasite was found to have a zymodeme typical of organisms belonging to the L. donovani complex. With the negative past history and in the absence of anti-Leishmania antibodies in her serum, post-kala-azar dermal leishmaniasis is an unlikely possibility, especially in view of the rarity of the complication in this part of the world. The infection was probably acquired during a recent visit to Aleppo, where cutaneous leishmaniasis is hyperendemic as similar cases have not been reported in Beirut. This case indicates the need to consider L. infantum strains in addition to L. tropica in cutaneous disease in Aleppo. This case also demonstrates that L. infantum can spread by the haematogenous route, even in a child without evidence of the immunosuppression, which usually predisposes to such spread.- - - - - - - - - - ranking = 1keywords = world (Clic here for more details about this article) |
3/17. South American cutaneous leishmaniasis of the eyelids: report of five cases in Rio de Janeiro State, brazil.PURPOSE: To describe American cutaneous leishmaniasis of the eyelids and highlight the main clinical and diagnostic features of lesions, which are rare in this location. DESIGN: Retrospective, noncomparative case series methods: Leishmanin skin test, touch preparations, histopathologic analysis, and culture in appropriate media were used for clinical confirmation and parasitologic diagnosis. Positive cultures were identified by the iso-enzymes technique. All patients were treated with pentavalent antimony applied intramuscularly. RESULTS: Leishmanin skin test was positive in all five patients. touch preparations, histopathologic analysis, and culture were performed in four patients. touch preparations were positive (presence of Leishman's bodies) in two patients; histopathologic analysis showed a granulomatous infiltrate in four patients and parasite was present in two patients; culture was positive in three patients, and in two the parasite was identified as Leishmania (Viannia) braziliensis. Therapy was effective for all patients. CONCLUSIONS: Cutaneous leishmaniasis of the eyelids is uncommon in the americas. The disease may present diagnostic difficulties when appearing in nonendemic areas. The clues for diagnosis are the clinical aspect of lesions, the epidemiologic data, and a positive Leishmanin skin test. Demonstration of parasite is not always possible. Pentavalent antimonial compounds are the therapy of choice. Formerly, transmission of leishmaniasis occurred only when humans penetrated forested areas and became an incidental host. Now, eyelid lesions are part of the changing pattern in the transmission of the disease. With the increase in ecotourism, these lesions may begin to be seen in air travelers returning to other parts of the world.- - - - - - - - - - ranking = 1keywords = world (Clic here for more details about this article) |
4/17. Cutaneous leishmaniasis.The incidence of leishmaniasis is increasing globally due to population and environmental changes. Ease of worldwide travel and immigrant populations means that the UK surgeon is more likely to encounter cutaneous lesions. Two cases are presented and treatment options discussed.- - - - - - - - - - ranking = 1keywords = world (Clic here for more details about this article) |
5/17. Extensive cutaneous leishmaniasis of the upper limb in a patient with leukemia.An unusual case of extensive cutaneous leishmaniasis of the upper limb in a patient with leukemia is presented. A trial of medical therapy (sodium stibogluconate) resulted in rapid healing of the large ulcers. The incidence of leishmaniasis is increasing globally as a result of the ease of travel and migrating populations. hand surgeons worldwide should have a high index of suspicion of this parasitic infection of the upper limb and should be aware of its unusual presentation in immunocompromised patients.- - - - - - - - - - ranking = 1keywords = world (Clic here for more details about this article) |
6/17. Cutaneous leishmaniasis: what about a new, inexpensive, effective, topical herbal remedy?Cutaneous leishmaniasis (CL) remains an important disease and public health problem in many parts around the world especially in the middle east. In the absence of adequate treatment, the lesion could become chronic and disfiguring. We report on three cases with chronic CL lesions that were successfully treated with topical application of a new herbal mixture named "Z-HE". It is clearly demonstrated that this inexpensive, simple, effective and non toxic topical drug has a promising curative role in the treatment of CL.- - - - - - - - - - ranking = 1keywords = world (Clic here for more details about this article) |
7/17. Old world cutaneous leishmaniasis in los angeles: a case report, overview of the current literature, and guide for the treating dermatopathologist.We describe a case of cutaneous leishmaniasis in a Spanish patient visiting los angeles. Leishmania species cause both cutaneous and visceral disease; the majority of infections with Leishmania are of the cutaneous form. Although leishmaniasis is a relatively rare occurrence in the united states, travel by united states' citizens to endemic regions and increased united states military operations in the middle east raise the chances of encountering cutaneous leishmaniasis. The following case report and overview of the current literature outlines the major morphologic findings and current diagnostic modalities available to diagnose cutaneous leishmaniasis.- - - - - - - - - - ranking = 4keywords = world (Clic here for more details about this article) |
8/17. Disseminated cutaneous leishmaniasis due to leishmania guyanensis: case of a patient with 425 lesions.Disseminated cutaneous leishmaniasis is characterized by the presence of a large (> or =10) number of lesions at several anatomic sites (head, limbs, and trunk). Most of the lesions are small, papular, and appear simultaneously with or secondarily to one or several ulcerated lesions of localized cutaneous leishmaniasis. We report the first case of disseminated cutaneous leishmaniasis in french guiana. It concerns a 24-year-old woman who tested negative for human immunodeficiency virus (hiv). The disease began with three lesions that became ulcerated. One week later, multiple papulo-nodular lesions appeared. We counted a total of 425 lesions. Leishmania were observed in the lesions. The species involved was L. guyanensis, which has never been described in a case of disseminated cutaneous leishmaniasis. The patient was rapidly cured by a single course of pentamidine. Disseminated cutaneous leishmaniasis should be distinguished from other types of leishmaniasis with multiple lesions. These include anergic diffuse cutaneous leishmaniasis, post-kala-azar leishmaniasis, and leishmaniasis associated with hiv infection.- - - - - - - - - - ranking = 0.13557501643655keywords = virus (Clic here for more details about this article) |
9/17. Tegumentary leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome in 2 patients with AIDS.Immune reconstitution inflammatory syndromes (IRISs) have been reported in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (AIDS) since the introduction of highly active antiretroviral therapy (HAART). This syndrome is characterized by clinical manifestations of opportunistic infections when signs of immune reconstitution are observed during therapy. We report on leishmaniasis, suggestive of HAART-induced iris, in 2 patients with AIDS. After beginning HAART, 1 patient presented with disseminated, tegumentary lesions, whereas the other patient's preexisting lesions worsened and became more extensive; however, at the same time, their CD4( ) T cell counts were recovering and their virus loads were decreasing significantly. The lesions healed with anti-Leishmania therapy.- - - - - - - - - - ranking = 0.27115003287311keywords = virus (Clic here for more details about this article) |
10/17. Post-kala-azar dermal leishmaniasis due to leishmania infantum in a human immunodeficiency virus type 1-infected patient.We report the first case of post-kala-azar dermal leishmaniasis due to leishmania infantum in a human immunodeficiency virus type 1-infected patient in australia. Molecular characterization of the isolate was performed using PCR restriction fragment length polymorphism targeting both repetitive sequences from Leishmania nuclear dna and repetitive kinetoplast dna minicircles for species differentiation.- - - - - - - - - - ranking = 0.67787508218277keywords = virus (Clic here for more details about this article) |
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