11/393. Application of artificial dermis prior to full-thickness skin grafting for resurfacing the nose.Two patients with nasal skin defects resulting from excision of rhinophyma and multiple angiofibromas were treated with artificial dermis followed by full-thickness skin grafts taken from the postauricular region. The secondary skin grafts took completely in both patients, and the postoperative results were excellent. Although a two-stage operation is required, application of artificial dermis prior to full-thickness skin grafting is a reliable method for resurfacing the nose.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
12/393. Epidermal maturation arrest.BACKGROUND: Cutaneous wound repair involves a complex and temporal integration of cytokines, formed blood components, extracellular matrix, and parenchymal cells. The normal healing process can be impeded at any step along its path by a variety of factors. OBJECTIVE: We present four cases of abnormal wound repair in patients whose defects were left to heal by second intention following Mohs micrographic surgery. In particular, these patients experienced an unusual delay in healing with an apparent arrest of epidermal maturation. RESULTS: Each appeared to respond to a topical steroid and/or ibuprofen. The intent of this therapy was to inhibit products of the arachadonic acid cascade or other cytokines that may have been hindering normal epidermal differentiation. CONCLUSION: We present four case reports, a brief review of epidermal reconstitution in wounds, and a possible explanation for why our therapy may have hastened wound repair in our patients.- - - - - - - - - - ranking = 2keywords = cell (Clic here for more details about this article) |
13/393. forehead lipoblastoma mimicking a hemangioma.A case of forehead lipoblastoma simulating a hemangioma in a male infant is reported, to alert pediatricians to this rare tumor and to increase the index of suspicion in atypical hemangiomas. A 2-month-old male infant developed a protruding forehead mass with increased vascularity. It demonstrated progressive and accelerated growth over the subsequent 6 months, unresponsive to steroid therapy. A magnetic resonance imaging scan supported the diagnosis of hemangioma because of the hypervascular nature of the lesion. Surgical excision was performed because of visual obstruction. Pathologic examination of the specimen was consistent with a very primitive lipoblastoma. This tumor is a rare, benign lesion of immature fat cells that is found almost exclusively in the pediatric population. Lipoblastomas are more common in males than females and frequently present as asymptomatic, rapidly enlarging, soft lobular masses on the extremities. Complete surgical excision is the definitive treatment. In the vast majority of reported cases, however, the preoperative diagnosis was incorrect, underscoring the diagnostic dilemma presented by these rare tumors.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
14/393. Proliferative actinic keratosis: three representative cases.OBJECTIVE: This article describes a new subtype of actinic keratosis that exhibits proliferative characteristics both histologically and clinically. We describe three representative cases occuring in the presence of infiltrative squamous cell carcinoma (SCC) and/or basal cell carcinoma (BCC). methods: Histories of each lesion in the three cases discussed were obtained. The lesions were removed by Mohs micrographic surgery. Permanent sections, stained with hematoxylin and eosin, were examined and studied under light microscopy. RESULTS: All three lesions had failed conventional treatment with liquid nitrogen and/or 5-fluorouracil (5-FU). Histologic examination of the lesions revealed sheets of dysplastic cells growing along the basal layer of the epidermis and migrating down hair follicles and sweat ducts. An associated infiltrative SCC and/or BCC was found in each case. CONCLUSIONS: Proliferative actinic keratosis is resistant to standard therapies because of deep migration of abnormal cells along hair follicles and sweat ducts. It has a strong propensity to develop infiltrative SCC and may occur concomitantly with BCC.- - - - - - - - - - ranking = 4keywords = cell (Clic here for more details about this article) |
15/393. An unusually aggressive trichoblastoma.Trichogenic tumors are neoplasms of the hair germ cell that usually exhibit benign behavior. We describe a case of a large invasive trichoblastoma requiring Mohs micrographic surgery for its removal. Immunohistochemical studies performed demonstrate overlapping features of this trichogenic tumor with basal cell carcinoma.- - - - - - - - - - ranking = 2keywords = cell (Clic here for more details about this article) |
16/393. Basal cell carcinoma in children: report of 3 cases.BACKGROUND: The peak incidence of basal cell carcinoma occurs in the seventh decade of life and is rare in children. When found in the pediatric age group, basal cell carcinoma is usually associated with a genetic defect, such as basal cell nevus syndrome, xeroderma pigmentosum, or nevus sebaceus. In areas of intense UV radiation exposure, such as the southwestern united states, children may be at increased risk of developing this malignancy de novo. OBSERVATIONS: Three children (2 boys, aged 8 and 16 years, and an 11-year-old girl) from Tucson, Ariz, with isolated basal cell carcinoma unassociated with any other disease or syndrome are described. CONCLUSIONS: Basal cell carcinoma in children is probably the result of a combination of UV radiation exposure and genetic background. Early recognition in children can prevent extensive tissue destruction and excess scarring after excision. A higher index of suspicion for basal cell carcinoma may also aid in prompt diagnosis of a possible genetic disorder, such as basal cell nevus syndrome.- - - - - - - - - - ranking = 11keywords = cell (Clic here for more details about this article) |
17/393. Serial excision of a large facial skin cancer.BACKGROUND: In the management of large facial neoplasms, the dermatologic surgeon must consider local factors affecting the success of closures. OBJECTIVE: Large facial neoplasms can be removed serially with Mohs micrographic surgery. Serial excision facilitates recruitment of adjacent normal skin for replacement of lesional skin, minimizing the risks of necrosis. methods: A large morpheaform basal cell carcinoma was excised serially. The initial defect was closed with an O to L advancement flap. The final excision and repair 2 months later consisted of a combination of primary closure with marsupialization and pursestring closure. A full-thickness skin graft was used to close the final defect. RESULTS: The patient had optimal cosmesis at 2-year follow-up. CONCLUSION: Large facial neoplasms can be excised serially. This technique, performed in the setting of Mohs micrographic surgery, takes advantage of "mechanical and biologic creep," resulting in excellent cosmesis and function.- - - - - - - - - - ranking = 2keywords = cell (Clic here for more details about this article) |
18/393. Localized multiple glomus tumors of the face and oral mucosa.We describe a 54-year-old patient with an unusual localization of localized multiple glomus tumors. She had several nodules on the left mandibular area, lower lip, and anterior part of the buccal mucosa. A biopsy taken from the left mandibular area showed cystically dilated vessels lined by endothelial cells and a few outer layers of glomus cells in the dermis to subcutis. Localized multiple glomus tumors are rare, and both their facial and oral mucocal localization are extremely rare.- - - - - - - - - - ranking = 2keywords = cell (Clic here for more details about this article) |
19/393. Orbital and facial granulocytic sarcoma (chloroma): a case report.Granulocytic sarcoma is an uncommon manifestation of myelogenous leukemias in which focal masses of immature myeloid cells from the granulocytic lineage infiltrate bone and soft tissue. It is most common in the pediatric population and may present at any time in the course of the disease, either concurrently with the onset of leukemia or during a remission or relapse. Occasionally, it may precede the clinical onset of acute myelogenous leukemia (AML), presenting a diagnostic challenge.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
20/393. Squamous cell carcinoma presenting as a cutaneous horn.A cutaneous horn is a variably sized, cohesive, keratotic, usually conical lesion associated with a broad spectrum of pathology at their base (benign, premalignant or malignant). Two cases of a squamous cell carcinoma in the face, with a horn formation are presented, highlighting the need for careful management of such lesions due to the high incidence of malignant or premalignant histology. The existing literature is also briefly reviewed.- - - - - - - - - - ranking = 5keywords = cell (Clic here for more details about this article) |
| <- Previous || Next -> |