1/10. corynebacterium pseudodiphtheriticum: an easily missed respiratory pathogen in hiv-infected patients.Despite being a well-known respiratory pathogen for immunocompromised patients, corynebacterium pseudodiphtheriticum has uncommonly been reported to occur in persons with infection attributable to hiv virus. We report three cases of respiratory tract infection attributable to C. pseudodiphtheriticum in hiv-infected patients and review the four previous cases from the medical literature. All of them were male with a median cd4 lymphocyte count of 110 cells/mm3 (range, 18-198/mm3); five of the seven cases occurred in persons for whom AIDS was diagnosed previously. The onset of symptomatology was usually acute and the most common radiographic appearance was alveolar infiltrate (six patients) with cavitation (two patients) and pleural effusion (two patients). In five of the seven cases, C. pseudodiphtheriticum was isolated from bronchoscopic samples and in the remaining two cases was recovered from lung biopsy (one patient) and sputum (one patient). In the three patients reported herein and in one previous case from the medical literature, quantitative culturing of bronchoscopic samples obtained through either bronchoalveolar lavage or protected brush catheter procedures yielded more than 10(3) CFU/mL. All the strains tested were susceptible to penicillin and vancomycin. Resistance to macrolides was common. Recovery was observed in six of the seven patients. C. pseudodiphtheriticum should be regarded as a potential respiratory pathogen in hiv-infected patients. This infection presents late in the course of hiv disease and it seems to respond well to appropriate antibiotic treatment in most of the cases. This easily overlooked pathogen should be added to the list of organisms implicated in respiratory tract infections in this population.- - - - - - - - - - ranking = 1keywords = sample (Clic here for more details about this article) |
2/10. corynebacterium striatum first reported case of prosthetic valve endocarditis.We describe the case of a prosthetic valve endocarditis in a 72-year-old woman. corynebacterium striatum was isolated in the blood samples. This organism has been described in a few cases of native valve endocarditis, but this is the first case reported of prosthetic valve endocarditis.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
3/10. Pneumonitis due to corynebacterium equi.corynebacterium equi, a known cause of pneumonitis in foals, calves, and swine, was isolated from the sputum and bronchial washings of a child with pneumonitis and leukemia. Clinical improvement followed the administration of chloramphenicol, and cultures of sputum specimens were sterile until relapse occurred after antibiotic therapy was terminated. Cure was achieved with a second course of chloramphenicol therapy. corynebacterium equi was not isolated from 1,181 samples of sputum from other immunosuppressed children with cancer.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
4/10. Is a black-pigmented corynebacterium species an opportunistic pathogen during pregnancy? literature review and report of 3 new cases.Isolation of black-pigmented corynebacterium species from human clinical samples has been reported, although rarely. review of the medical literature revealed 3 reports of culture isolation of these unusual bacteria. All were recovered from the female genital tract, and 1 case was associated with spontaneous abortion. Genetic characterization of these isolates indicates that they are similar and probably represent a novel pathogen in the genus corynebacterium. We report 3 additional bacterial isolates sharing similar phenotypic and/or genotypic characteristics that were recovered from the genital tract of women who had complications of pregnancy. Similarities in these cases suggest that this newly recognized corynebacterium species might be an opportunistic pathogen in pregnancy.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
5/10. Postoperative corynebacterium macginleyi endophthalmitis.A 72-year-old man with chronic endophthalmitis who received steroid treatment for 3 months came to our center. Sterile endophthalmitis after cataract extraction had been diagnosed. Aqueous samples including smears, classic cultures, and polymerase chain reaction were taken for microbiological study. Amplified dna was sequenced to identify the pathogen. polymerase chain reaction amplification was positive for bacteria. sequence analysis showed corynebacterium macginleyi as the causal agent in 48 hours. The culture and smear stains from the ocular samples were negative. The patient was successfully treated with vancomycin. polymerase chain reaction and subsequent dna-typing were useful in detecting the microorganisms that caused the chronic endophthalmitis.- - - - - - - - - - ranking = 1keywords = sample (Clic here for more details about this article) |
6/10. corynebacterium jeikeium endocarditis: a systematic overview spanning four decades.skin flora is an important source of microorganisms that cause infective endocarditis. While staphylococcal and beta-hemolytic streptococcal species are well-recognized components of skin flora that can cause infective endocarditis, other skin flora rarely produce endocardial infection. One species of corynebacterium has received the most attention, corynebacterium jeikeium. This bacterium, a gram-positive rod that is a strict aerobe, is known to cause mechanical prosthetic valve infection and vancomycin is generally required for treatment of this multidrug-resistant organism. Following treatment of an unusual case of bioprosthetic valve endocarditis due to C. jeikeium, a medline search for English-language articles published from January 1966 to October 2004 was performed. Reports of C. jeikeium endocarditis cases with culture of either blood or cardiac surgery tissue samples positive for C. jeikeium and with clinical and echocardiographic findings of infective endocarditis were reviewed. Clinical data and results of diagnostic procedures were examined. All 38 patients with C. jeikeium endocarditis reported in the literature had at least one predisposing condition for the development of infective endocarditis. The majority of patients (74%) had involvement of a prosthetic heart valve. The mortality attributed to C. jeikeium endocarditis was 33% and was similar in patients who did and did not undergo valve replacement. This relatively high mortality rate mandates that clinicians be aware of this rare endocardial infection. C. jeikeium is a rare cause of endocarditis and it more commonly infects prosthetic valves. Careful scrutiny is required when C. jeikeium is isolated from a blood culture, particularly in patients with underlying prosthetic cardiac valves.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
7/10. urinary tract infection caused by corynebacterium group D2: report of 82 cases and review.corynebacterium group D2 (CGD2) is a slow-growing, urea-splitting, multiantibiotic-resistant microorganism that is frequently isolated from urine samples and that, in certain circumstances, produces infection of the lower urinary tract (acute and chronic cystitis) and the upper urinary tract (pyelonephritis). This paper analyzes (by means of a retrospective and partially prospective clinical protocol) our experience with 82 patients with CGD2 bacteriuria. The infection was symptomatic in 62% of cases, and the clinical diagnoses included acute and chronic cystitis and pyelonephritis with or without bacteremia. Because CGD2 infection of the urinary tract may require specific antimicrobial treatment and because CGD2 is a fastidious microorganism, we recommend prolonged incubation of urine cultures (up to 48-72 hours), especially if the routine culture is negative, when patients are symptomatic, have alkaline urine, or have struvite crystals in the urine sediment.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
8/10. Septicemia due to corynebacterium haemolyticum.A 65-year-old man in generally good health presented with symptoms of sepsis and mental confusion. corynebacterium haemolyticum was isolated from three blood cultures, and a significant increase in the titer of immunofluorescent antibodies to the infecting organism was observed. Antigen of C. haemolyticum was demonstrated by double immunodiffusion in samples of cerebrospinal fluid and urine. The patient recovered after i.v. administration of 20 Mu/day penicillin. This is, to the best of our knowledge, the third reported human infection with C. haemolyticum with involvement of the central nervous system.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
9/10. corynebacterium ulcerans infection associated with untreated milk.Infection with corynebacterium ulcerans has been previously reported in association with cows' milk. Further evidence that the disease is a zoonosis is given in this report of infection in a consumer of untreated milk. The organism was isolated from a sample of milk, and from two cows in a herd of 93 Jersey cattle. One of the farm workers was a symptomless nasal carrier.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
10/10. corynebacterium pseudodiphtheriticum: a respiratory tract pathogen in adults.corynebacterium pseudodiphtheriticum has been reported to be an uncommon respiratory pathogen. We describe the clinical and microbiologic features of 17 patients from whose sputum C. pseudodiphtheriticum was isolated. patients were identified through a review of the reports from the clinical microbiology laboratory at York Hospital, a community teaching hospital, from October 1990 through April 1993; 17 patients with respiratory infection caused by C. pseudodiphthriticum were identified. There were 12 cases of bronchitis and five of pneumonia. An underlying systemic condition, particularly congestive heart failure, chronic obstructive pulmonary disease, diabetes mellitus, or malignancy, was common. Onset of symptomatology was acute for most patients, but fever was noticeably absent in almost two-thirds of the cases. Isolates were uniformly susceptible to the beta-lactam antibiotics, vancomycin, and trimethoprim-sulfamethoxazole, but resistance to clindamycin and erythromycin was common. The isolation of diphtheroids from a properly obtained sputum sample from a patient with respiratory tract infection should not always be dismissed as due to contamination. The isolation, identification, and susceptibility testing of C. pseudodiphtheriticum from respiratory tract specimens may provide information useful for treatment of patients.- - - - - - - - - - ranking = 0.5keywords = sample (Clic here for more details about this article) |
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