1/43. Papillary thyroid carcinoma with nodular fasciitis-like stroma. Pitfalls in fine-needle aspiration cytology.Papillary thyroid carcinoma with nodular fasciitis-like stroma is one of the rare variants of papillary thyroid carcinoma. The problems posed by the exuberant nodular fasciitis-like stroma, which obscures the neoplastic nature of the tumor, are recognized in surgical pathology but have received little attention in the cytopathology literature. We report a rare case of papillary thyroid carcinoma in which nodular fasciitis-like stroma posed difficulty on fine-needle aspiration cytology. The differential diagnosis of fibroproliferative processes in thyroid fine-needle aspirations is also discussed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/43. hypopigmentation of a papillary carcinoma arising in a black thyroid.We report a case of an unpigmented papillary carcinoma arising in a black thyroid induced by minocycline. Black thyroid syndrome is an unusual pigmented change seen almost exclusively in patients on minocycline, apparently resulting from an oxidative interaction between thyroid peroxidase and the drug. Twenty-six cases have previously been reported in the English literature, nine of which described an associated thyroid neoplasm. Four of these nine neoplasms were described as pale or hypopigmented. The nature of the lesion against the background of pigmentation suggests diminished function of the thyroid peroxidase in this clonal population.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/43. Incidentally discovered papillary carcinoma of the thyroid: value of ultrasonographic follow-up. A case-report.Incidentalomas of the thyroid are common small nodules found occasionally during imaging procedures. Their pathological nature is generally benign, but about 4% may harbour malignant tissue. Most current studies only suggest clinical follow-up, but there are no data about the natural history of malignant incidentalomas. The authors describe a patient with multiple incidentaloma of the thyroid submitted to fine-needle aspiration biopsy because his larger nodule grew 50% in 3 months at ultrasonographic follow-up. The cytological examination suggested thyroid malignancy in this nodule and surgical pathology showed multicentric papillary carcinoma. This case suggests that the larger diameter of a malignant incidentaloma may change rapidly. If more time had been spent before repeating the ultrasonography, the volume could have changed even more and the prognosis could have been changed as indicated by most prognostic score indexes.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/43. FNAC of papillary and solid epithelial neoplasm of pancreas--a case report.A case of solid papillary epithelial neoplasm (PSEN) of pancreas in a young woman is reported in which the nature of tumour was recognised pre-operatively by ultrasound guided Fine needle aspiration. The pre-operative cytologic diagnosis enabled prompt and appropriate surgical treatment. FNAC revealed large cell clumps in the aspirate showing branching papillary appearance in which multiple layers of tumour cells surrounded central vascular stalks. The above was confirmed on histopathological examination of the excised tumour tissue.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/43. Upper retropharyngeal node involvement in differentiated thyroid carcinoma demonstrated by 131I scintigraphy.We report four patients with papillary thyroid cancer who had upper retropharyngeal node involvement demonstrated by 131I scintigraphy. Three patients presented with a thyroid nodule and enlarged jugular nodes. Total thyroidectomy was performed with node dissection. pathology demonstrated papillary carcinoma with several metastatic nodes. 131I scanning 4 weeks after surgery demonstrated increased uptake in an upper retropharyngeal node. In one patient, thyroidectomy had been performed 21 years previously. Increased thyroglobulin level led to 131I scanning, which showed focal retropharyngeal uptake. All four patients had asymmetrical uptake at mouth level with focal uptake close to the sagittal plane. A lateral projection showed focal uptake between the base of the skull and the mandibular angle, behind the region of the mouth and nose. CT in all cases and MRI in one case confirmed the presence of an enlarged node. The mass was removed surgically in two patients and pathology confirmed the papillary nature of the metastatic node. Two patients were treated by 131I. Focal uptake of 131I in the region of the mouth is ambiguous, since salivary uptake of 131I is a common finding on scintigraphy. In cases of asymmetrical uptake in the region of the mouth, a lateral projection of the head therefore allows the correct diagnosis.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/43. Papillary clear cell carcinoma of the thyroid gland.A case of an unusual papillary clear cell carcinoma of the thyroid gland is described. The patient expired 17 days after operative biopsy and thyroxine suppression. Special stains were helpful in differentiating renal cortical carcinoma and parathyroid malignant disease from primary papillary clear cell carcinoma of the thyroid. Ultrastructural features of this tumor may relate to the effects of thyroid stimulating hormone as well as the malignant nature of the tumor.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/43. Thyroid papillary microcarcinoma. Is it really a pitfall of fine needle aspiration cytology?OBJECTIVE: To assess the role of fine needle aspiration (FNA) of the thyroid in the diagnosis of papillary microcarcinoma. STUDY DESIGN: Eight cases of papillary microcarcinoma were diagnosed by fine needle aspiration. On histologic examination they were found to be adjacent to larger nodules of interest. The microcarcinomas were inadvertently sampled when sampling the larger, dominant nodules. RESULTS: None of the eight dominant nodules were papillary carcinoma; seven were benign lesions, and one was an angioinvasive Hurthle cell carcinoma. In three cases the microcarcinomas were situated within the capsule of a hyperplastic nodule. On histologic examination, five cases had multifocal microcarcinomas, with one case having multiple lymph node metastases. Based on the clinical findings and morphologic features, there were no definitive cytologic findings that could distinguish between "incidental" microcarcinoma and clinically significant papillary carcinoma. CONCLUSION: The detection of microcarcinoma by FNA should not be considered a false positive finding since the exact nature of the lesion cannot be determined until complete histologic evaluation reveals it to be truly incidental and clinically insignificant.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/43. Characteristics of the tumours of the urinary tract in patients with endemic nephropathy.The authors have studies in detail the development of tumours in the urinary tract of patients with endemic nephropathy (EN). They have found tumours in about 40% of these patients. They have performed operations for tumours of the urinary tract in 88 patients with EN, with a different localization in the upper part of the urinary tract. In 10% of the cases they have found bilateral tumours. The histological examination has revealed papillary tumours of a malignant character. They have shown specific symptoms of these tumours, not found with other tumours of the urinary tract. The main symptom is renal insufficiency which causes the death of the patients. The evolution of these tumours is comparatively slow and the nature of EN has determined the operative approach of the authors, a radical operation with haemodialysis when indicated. The paper is illustrated with four typical cases.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
9/43. Papillary thyroid carcinoma with fibromatosis-like stroma: a report of two cases.Two cases of an unusual morphologic variant of papillary thyroid carcinoma (PTC) are reported. Tumor cells had nuclear features of a typical papillary carcinoma, i.e., overlapping, pale to ground glass and/or grooved nuclei. Tumors were characterized by an extensive stromal component accounting for 40-60% of the tumor. It has been reported that PTC is associated with a variable degree of fibrosis, but the exuberant proliferation of fibroblasts resembling fibromatosis is rare. The histogenesis and clinicopathologic significance of PTC have not been fully clarified because of its rarity. It is possible that the malignant nature of these PTC lesions may be overlooked because attention is focused on the stromal component of the tumor. A diligent search for this variant of papillary carcinoma is important.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
10/43. Papillary carcinoma of the thyroglossal duct cyst in childhood.Thyroglossal duct carcinoma is a rare malignancy that is usually diagnosed postoperatively. Approximately 150 cases have been reported in the literature. Eighty-five percent of these were papillary carcinomas. Controversies exist concerning its nature and treatment. In this report, we present an 11-year-old boy with an anterior cervical cystic mass originating in the thyroglossal duct. After a primary Sistrunk procedure, the cyst and tract extending to the foramen caecum at the base of the tongue in continuity with the midportion of the hyoid bone were resected. Histopathologic study demonstrated a papillary carcinoma. After 4 months of follow-up, the patient is asymptomatic without any evidence of recurrence. The clinical and histopathological features and therapeutic options are discussed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
| | Next -> |