1/28. Spindle-cell variant of intralingual lipoma--report of a case with literature review.A true lipoma is a rare lesion in the oral cavity. A histologically distinct variant is the spindle-cell variety, which is an innocuous lesion that can simulate a myxoid liposarcoma. We report a case of intra-oral spindle-cell lipoma in a 42-year-old female and have reviewed the literature pertaining to this unusual histopathological entity. awareness of the condition is essential for both clinicians and pathologists to avoid any misinterpretation of the benign nature of this condition.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/28. Synchronous oral leiomyosarcoma and squamous cell carcinoma.An unusual case of synchronous squamous cell carcinoma and leiomyosarcoma of the oral cavity is reported in a patient without any identified environmental risk or predisposing factors. The invasive squamous cell carcinoma involved the tongue, whereas the leiomyosarcoma was located in the soft palate. No immunostaining was found for human papillomavirus or Epstein-Barr virus, and in situ hybridization showed negativity for human papillomavirus dna within the tumor cells. Alterations of bcl -2, c-erb -b2 and Rb oncoproteins were not found immunohistochemically. Overexpression of p53 was detected by immunohistochemistry in both tumors, but p53 gene mutations were not found by polymerase chain reaction. Neither loss of heterozygosity of p53 nor microsatellite instability was detected in this patient. The smooth muscle nature of the leiomyosarcoma was confirmed by immunohistochemical methods. To our knowledge, synchronous smooth muscle and epithelial oral tumors have not previously been reported.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/28. Multiple infiltrating lipomas of the tongue.A rare case of multiple infiltrating lipomas in the tongue of a 54-year-old man is reported. There have been only five previously reported cases of infiltrating lipoma of the tongue. They were all solitary in nature. The present lesion is the first case reported in the English literature of multiple infiltrating lipoma of the tongue. Because of its infiltrating nature, this tumour may be mistaken for a liposarcoma. achievement of adequate surgical margins is essential, as the recurrence rate may be as high as 62.5 per cent without complete excision.- - - - - - - - - - ranking = 2keywords = nature (Clic here for more details about this article) |
4/28. Lingual localization of an inclusion body fibromatosis (Reye's tumor).This report illustrates a lingual localization of an inclusion body fibromatosis, the so-called Reye tumor or infantile digital fibromatosis (IDF). The light microscopic features were identical to those found in IDF, showing eosinophilic perinuclear inclusions located in spindle-shaped cells arranged in interlacing fascicles. The immunocytochemical and ultrastructural findings suggested a fibroblastic and/or myofibroblastic nature of the proliferative cells. However, the inclusions in our case were strongly stained with vimentin and their ultrastructural appearance was in keeping with intermediate filaments. These findings have never been described in other reports of fibromatosis. Whereas most reviews state that IDF occurs exclusively on the digits, this unique case describes its possible occurrence in the tongue.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/28. Detecting oral cancer: a new technique and case reports.The VELscope is an important aid in patient assessment, and when added to a well-thought out clinical assessment process that takes into consideration the age of the patient and risk factors that include tobacco, alcohol, and immunologic status, it increases the clinician's ability to detect oral changes that may represent premalignant or malignant cellular transformation. False positive findings are possible in the presence of highly inflamed lesions, and it is possible that use of the scope alone may result in failure to detect regions of dysplasia, but it has been our experience that use of the VELscope improves clinical decision making about the nature of oral lesions and aids in decisions to biopsy regions of concern. Where tissue changes are generalized or cover significant areas of the mouth, use of the scope has allowed us to identify the best region for biopsy. As with all clinical diagnostic activities, no single system or process is enough, and all clinicians are advised to use good clinical practice to assess patients and to recall and biopsy lesions that do not resolve within a predetermined time frame. Lesions that are VELscope-positive and absorb light need to be followed with particular caution, and if they do not resolve within a 2-week period, then further assessment and biopsy are generally advised. It is much better to occasionally sample tissue that turns out to be benign than to fail to diagnose dysplastic or malignant lesions. In our fight to protect patients from cancer, the VELscope improves our odds for early detection, hopefully resulting in fewer deaths from oral cancer.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/28. Congenital teratoma of the tongue: a case report and review of the literature.Teratomas of the head and neck are rare. They develop in neonates and are associated with feeding difficulty, airway obstruction, and difficulty in swallowing (which may cause polyhydramnios). Although some tumors consist of immature elements, teratomas of the head and neck are mature in nature, and excision is the most effective treatment. We present a case report of a neonate with a polypoid mass protruding from his mouth. He exhibited respiratory arrest immediately after birth and underwent intubation. The mass, which was completely excised, was histologically identified as a mature teratoma.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/28. glycogen-rich clear cell carcinoma in the tongue. A cytochemical and ultrastructural study.An unusual epithelial neoplasm arising in the tongue of a 17 month-old-boy was studied by light and electron microscopy. By routine light microscopic examination, the tumor cells exhibited clear cytoplasm. Histochemical studies revealed the presence of large amounts of periodic acid-Schiff (PAS)-positive, diastase-labile material in the cytoplasm. Ultrastructurally, this material was identified as electron dense particles (20-35 nm diameter) of beta-glycogen. The epithelial nature of the tumor cells was suggested by the presence of intercellular junctions, segments of basal lamina, and well-developed Golgi complexes. Furthermore, the cells were often clustered and formed abnormal lumina with small microvillus projections. Several histologic features, such as lack of capsule, infiltration of muscle and invasion of blood vessel, indicated that this neoplasm was malignant. However, there was no recurrence or distant metastases more than 2.5 years after surgical excision, suggesting a low-grade malignancy. The glycogen-rich clear cell variant of adenocarcinoma is histogenetically derived from minor salivary glands like most of the glandular neoplasms in the oral cavity. Investigation of the literature on adult and childhood minor salivary gland neoplasms revealed that the glycogen-rich, clear-cell variant of adenocarcinoma has not previously been reported in the tongue.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/28. Expression of intermediate filaments and stromal proteins in granular cell tumor of the tongue.Intermediate filament subunits as well as components of the extracellular matrix, were localized in three cases of granular cell tumor of the tongue. Of the five intermediate filament families, only vimentin was present within the tumor cells. No labeling was obtained with antibodies to cytokeratin, desmin, neurofilaments, and glial filaments; this suggests that this tumor is not derived from epithelium, muscle, neural, or astrocytic origins, respectively. Immunofluorescent staining of the tissue with antibodies to fibronectin and to collagen indicated that the tumor contained low levels of these extracellular matrix proteins. The results suggest the possible use of antibodies to intermediate filaments as histogenetic markers for the clarification of the origin of tumors whose nature cannot be unequivocally determined by conventional histopathologic methods.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
9/28. Case report of chondroma of the tongue.A 20-year-old Japanese woman was referred to the hospital for examination and treatment of an asymptomatic swelling of the left dorsum of the tongue. Intraoral examination revealed that the tumor was covered with normal mucosa and oval, firm on palpation and measured 1.5 cm in diameter. The lesion was movable suggesting benignity in nature. No cervical lymph node was palpated. The cut surface of the extirpated tumor after fixation showed a chalky white "core region" surrounded with a yellowish white adipose tissue. Histopathological examination revealed the lesion to be a benign cartilaginous tumor. We report this case of chondroma which arose from the tongue because of its rarity, and reviewed related literature.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
10/28. Oral dysplasia and in situ carcinoma: clinicopathologic correlations of eight patients.Eight patients with multiple oral dysplastic epithelial lesions were followed by clinical examinations and serial biopsies for periods varying from four to 22 years. The dysplasias and in situ carcinomas were characterized by persistence, recurrence, and eventual progression to invasive squamous cell carcinoma. It could not be determined whether dysplasia and in situ carcinoma were separate clinical-pathologic entities with similar end points or whether they were part of a continuum in a spectrum of epithelial neoplasia. The need for close clinical observation and local excision was emphasized because of the multiplicity of lesions and because of the protracted clinical course. Treatment of these patients was problematic because of similarities of the disease to lichen planus. It is possible that they had a premalignant disease process that mimicked lichen planus, or that they had an unusual form of lichen planus for which criteria have not been established. The progressive nature of the disease was exemplified by one death, one patient with cervical metastasis, and one with generalized remote metastatic disease.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
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