11/64. Thymic epithelial hyperplasia with nodular sclerosis Hodgkin's disease.We report a case of simultaneous occurrence of thymic epithelial hyperplasia and Hodgkin's disease. A computed tomographic scan of the chest revealed a tumor in the anterior mediastinum and conspicuous swelling of lymph nodes in the upper and lower mediastinum. The anterior mediastinal tumor was histologically diagnosed as thymic epithelial hyperplasia, while the lymph nodes were nodular sclerosis Hodgkin's disease. Our findings suggest that thymic hyperplasia might be directly involved in the pathology of at least some cases of Hodgkin's disease.- - - - - - - - - - ranking = 1keywords = hyperplasia (Clic here for more details about this article) |
12/64. Massive benign thymic hyperplasia in a six-month-old girl: case report.A 6-month-old girl presented with respiratory symptoms with a large right-sided mediastinal mass noted on diagnostic imaging. Percutaneous biopsy revealed normal thymic tissue. steroids were administered with no response. Right thoracotomy and complete thymectomy were performed. The specimen weighed approximately eight to ten times normal weight, and histology and flow cytometry revealed normal thymic tissue consistent with benign hyperplasia. The child has remained tumor free for a year since surgery. The rare nature of this tumor leads us to report this case and review the current literature.- - - - - - - - - - ranking = 0.71428571428571keywords = hyperplasia (Clic here for more details about this article) |
13/64. Thymic hyperplasia with hemorrhage simulating recurrent hodgkin disease after chemotherapy-induced complete remission.BACKGROUND. Thymic hyperplasia after successful treatment of malignant disease is a well-documented phenomenon, particularly in younger patients with testicular carcinoma. However, it has been reported only sporadically in association with hodgkin disease. The authors report the first instance of an adult with nodular sclerosing hodgkin disease who had thymic hyperplasia develop after clinical and radiographic complete remission (CR) with chemotherapy alone. methods. In addition to the current case, 20 other instances of thymic hyperplasia have been culled from the literature and analyzed. RESULTS. The median age of these 21 patients was 23 years of age (range, 8-40 years of age). Thymic hyperplasia was noted after treatment was initiated or completed in all but two patients; and all did well, with one exception: a 17 year-old boy who was inadvertently treated for relapsed hodgkin disease and who died of fibrinous pneumonitis and nocardia, with pathologic CR noted at autopsy. CONCLUSIONS. Thymic hyperplasia in association with hodgkin disease appears to be a favorable prognostic phenomenon, restricted to younger patients in the first modal peak of Hodgkin incidence. prospective studies have yet to be performed.- - - - - - - - - - ranking = 1.2857142857143keywords = hyperplasia (Clic here for more details about this article) |
14/64. PET scan evaluation of thymic mass after autologous peripheral blood stem-cell transplantation in an adult with non-Hodgkin's lymphoma.We report the case of a 31-year-old man with anaplastic large-cell lymphoma successfully treated with chemotherapy who showed mediastinal widening 5 months after autologous stem-cell transplantation. CT scan and PET evaluations were consistent with the diagnosis of benign thymic hyperplasia. Because of the rapid and aggressive course of this type of lymphoma, and the progressive widening of the mass at CT scan, we performed a mediastinal biopsy that confirmed these findings, showing normal thymic tissue. This is the first case of benign thymic hyperplasia defined with FDG-PET and confirmed by histologic evaluation.- - - - - - - - - - ranking = 0.28571428571429keywords = hyperplasia (Clic here for more details about this article) |
15/64. A case of myasthenia gravis complicated with hyperthyroidism and thymic hyperplasia in childhood.We report here a case of myasthenia gravis complicated with hyperthyroidism and thymic hyperplasia. The patient was a 13-year-old girl with struma and hyperthyroidism which began at age 12. Two weeks following the initiation of treatment against hyperthyroidism she developed left blepharoptosis, diplopia, and dysphagia, which responded promptly to edrophonium administration. An increase of the anti-acetylcholine receptor antibody was found in the serum. A chest CT showed a large soft tissue mass in front of the ascending aorta, which was proven histopathologically as thymic hyperplasia. The patient underwent an extensive thymectomy and was placed on combination therapy with an anti-thyroid drug, glucocorticosteroid, and an anti-cholinesterase drug. Her symptoms and signs have been well controlled by this treatment. Coexistence of myasthenia gravis, hyperthyroidism, and thymic hyperplasia in childhood have never been documented in literature.- - - - - - - - - - ranking = 1keywords = hyperplasia (Clic here for more details about this article) |
16/64. diagnostic imaging and therapy in a case of myasthenia gravis associated with thymic hyperplasia.The diagnostic approach to a patient with myasthenia gravis to verify the presence of thymic hyperplasia/thymoma is presented. The study of the mediastinal region was necessary. Mediastinal MRI showed the presence of a mass. The differential diagnosis between a mediastinal and an extramediastinal lesion is possible with MRI for its high contrast resolution, good spatial resolution and multiplanarity that allow the detection, localization, evaluation of the extent and/or infiltration of adjacent tissues/organs based on the analysis of adipose cleavages and typing in the different pulse sequences of pathologic tissue with contrast enhancement. Definitive diagnosis of thymic hyperplasia was established. Therefore surgery should be essentially associated with the severity of the clinical presentation rather than with thymic hyperplasia.- - - - - - - - - - ranking = 1keywords = hyperplasia (Clic here for more details about this article) |
17/64. Thymic hyperplasia associated with hodgkin disease and thyrotoxicosis.A 19-year-old woman had a residual gallium-sequestering mediastinal mass after treatment for hodgkin disease. Coincidentally, she also had hyperthyroidism. The initial concern was that the mass was residual hodgkin disease. Thymic hyperplasia has been described in association with both these conditions. The mass disappeared after treatment of her hyperthyroidism.- - - - - - - - - - ranking = 0.71428571428571keywords = hyperplasia (Clic here for more details about this article) |
18/64. Thymic rebound following successful chemotherapy of B-lymphoma in an adolescent boy.Four months after termination of successful chemotherapy for epipharyngeal B-non-Hodgkin lymphoma, an enlarging anterior mediastinal mass was discovered in a 15-year-old boy. There was no other suspicion of tumour recurrence. A simple thymic rebound was likely and a conservative management was chosen. Follow up for more than 12 months was uneventful. The frequency of thymic hyperplasia after termination of chemotherapy is discussed. It is a benign immunological rebound phenomenon and does not require operative intervention.- - - - - - - - - - ranking = 0.14285714285714keywords = hyperplasia (Clic here for more details about this article) |
19/64. myasthenia gravis with thymus hyperplasia and pure red cell aplasia.A case of myasthenia gravis (MG) with thymus hyperplasia and pure red cell aplasia (PRCA) is reported. A 57-year-old woman was diagnosed as having MG and was treated with thymectomy 26 years ago. The histology of the resected thymus was thymic lymphoid follicular hyperplasia. She developed rapidly progressive anemia and a bone marrow examination revealed PRCA. Her hematological results improved with oral administration of cyclosporine A. Cases of MG, thymoma and PRCA have been reported in the literature. We report the first case of MG without thymoma and PRCA.- - - - - - - - - - ranking = 0.85714285714286keywords = hyperplasia (Clic here for more details about this article) |
20/64. Multilocular thymic cyst associated with follicular hyperplasia: clinicopathologic study of 4 resected cases.We report here 4 cases of multilocular thymic cysts (MTCs) with reactive lymphoid follicular hyperplasia. They were admitted to our hospital to examine anterior mediastinal masses demonstrated on chest computed tomographic scans. Three patients presented high-grade intermittent fever, and 2 patients were associated with Sjogren syndrome with elevated serum antinuclear antibody levels. All patients were subjected to extended thymectomy. Interestingly, their fever disappeared immediately after surgery. Histologically, the lesions were characterized by several cystic spaces separated by various thick walls with dense lymphoid tissue containing large reactive germinal centers. The inner cyst walls were lined by flattened cuboidal epithelia in some portions. Columnar epithelia with focal cilia were partially observed in 2 cases. These pathological findings led to a diagnosis of MTCs that were thought to result from cystic transformation of medullary duct derivatives by acquired inflammatory processes. The pathological findings, together with clinical courses of our cases, suggest that inflammation accompanied by autoimmune diseases may play, in part, an important role in the development of MTCs.- - - - - - - - - - ranking = 0.71428571428571keywords = hyperplasia (Clic here for more details about this article) |
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