1/8. Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schonlein purpura.Henoch-Schonlein purpura (HSP) is the most common vasculitis in children. It is a multisystemic disease but pulmonary haemorrhage is extremely rare. We present the case of a 6-year-old boy with Henoch-Schonlein purpura, pulmonary haemorrhage and severe renal involvement. The patient responded to a combination of intravenous methylprednisolone and cyclophosphamide. A review of the literature revealed that young age may be a good prognostic sign and that immunosuppressive drugs and supportive management are essential in the treatment. Renal biopsy is helpful in the differential diagnosis of HSP-mimicking pulmonary vasculitic syndromes. Combining cyclophosphamide with glucocorticoids may improve the outcome in severe HSP cases with pulmonary haemorrhage.- - - - - - - - - - ranking = 1keywords = haemorrhage (Clic here for more details about this article) |
2/8. Successful treatment of mesenteric vasculitis caused by Henoch-Schonlein purpura with methylprednisolone pulse therapy.Although mesenteric vasculitis due to Henoch-Schonlein purpura (HSP) is relatively uncommon, it is the most life-threatening manifestation associated with high mortality. We describe a 15-year-old boy with HSP who had massive gastrointestinal bleeding and ileus but delayed onset of the purpuric rash. Abdominal ultrasonography revealed thickening of both small and large intestinal walls, and CT found prominent mesenteric vessels with comb sign and double wall of the bowel. These findings were consistent with mesenteric vasculitis and bowel ischaemia. The ischaemic intestine recovered after methylprednisolone pulse therapy and surgical intervention was avoided. Our report suggests that corticosteroid pulse therapy may help controlling HSP with massive gastrointestinal haemorrhage and ischaemic bowel due to widespread mesenteric vasculitis.- - - - - - - - - - ranking = 0.14285714285714keywords = haemorrhage (Clic here for more details about this article) |
3/8. Henoch-Schonlein purpura with intracerebral haemorrhage.Henoch-Schonlein purpura is a leucocytoclastic vasculitis commonly seen among children and young adults. Neurological complications, though rare, include focal cerebral deficit, coma, convulsion, subarachnoid hemorrhage and chorea. We are reporting a 12 years boy with Henoch-Schonlein purpura who developed a large intracerebral hematoma in right occipital lobe. He made an uneventful recovery with conservative treatment and one year follow up revealed no major neurological sequelae.- - - - - - - - - - ranking = 0.57142857142857keywords = haemorrhage (Clic here for more details about this article) |
4/8. Complex extra-intestinal complications of ulcerative colitis in a patient with alpha1-antitrypsin deficiency.Ulcerative colitis (UC) can manifest with a variety of extra-intestinal disorders frequently affecting the skin, joints, and liver. An aetiologic role of alpha1-antitrypsin deficiency in chronic inflammatory bowel disease has recently been suggested. We report a patient with UC and alpha1-antitrypsin deficiency who presented with disseminated cutaneous leucocytoclastic vasculitis clinically appearing with target-like purpuric patches and haemorrhagic oedemas. In addition, he displayed acute haemorrhage of the eyes and the respiratory tract consistent with a systemic vasculitic process. Moreover, he had autoimmune haemolytic anaemia. Systemic vasculitides, such as Wegener's granulomatosis, churg-strauss syndrome, and microscopic polyangiitis, could widely be excluded. Systemically administered glucocorticosteroids and azathioprine led to dramatic improvement of extra-intestinal symptoms. On the basis of alpha1-antitrypsin deficiency and UC, the present patient likely developed severe systemic vasculitis with multi-organ involvement. UC should at times be viewed within the context of a more generalized immune imbalance affecting multiple organs, and not as an isolated pathological entity. Testing for alpha1-antitrypsin deficiency in UC patients may detect individuals at higher risk of severe extra-intestinal involvement.- - - - - - - - - - ranking = 0.14285714285714keywords = haemorrhage (Clic here for more details about this article) |
5/8. Pulmonary haemorrhage in Henoch-Schonlein purpura.A case of Henoch-Schonlein purpura with fatal pulmonary haemorrhage and capillaritis is described.- - - - - - - - - - ranking = 0.71428571428571keywords = haemorrhage (Clic here for more details about this article) |
6/8. factor xiii (fibrin stabilising factor) in Henoch-Schonlein's purpura.In 13 out of 17 consecutive children with Henoch-Schonlein's purpura the factor xiii determined with the dansyl cadaverine method was found to be decreased during the acute phase. The decrease is assumed to be due to a specific degradation by proteolytic enzymes liberated from inflammatory cells, with defective local haemostasis as a result. This assumption is strengthened by the observation that treatment with factor xiii combined with an antifibrinolytic drug controlled life-threatening gastro-intestinal bleeding in one of the patients. It would therefore appear that such treatment might offer a new possibility of controlling severe haemorrhages in Henoch-Schonlein's purpura.- - - - - - - - - - ranking = 0.14285714285714keywords = haemorrhage (Clic here for more details about this article) |
7/8. Henoch Schonlein purpura presenting with pulmonary haemorrhage.A young woman presented with arthralgia, a rash and dramatic haemoptysis, and renal involvement was indicated by proteinuria, haematuria and a rising serum creatinine. A systemic vasculitic disorder was suspected initially, but the diagnosis of Henoch-Schonlein purpura was established by the finding of mesangial IgA deposits on renal biopsy. Immunofluorescent study of renal biopsy material is vital to diagnosis where the clinical features of Henoch-Schonlein purpura and those of the systemic vasculitides with renal involvement prove to be indistinguishable.- - - - - - - - - - ranking = 0.57142857142857keywords = haemorrhage (Clic here for more details about this article) |
8/8. Pleural haemorrhage in Henoch Schonlein purpura.We describe a seven-year old boy with Henoch-Schonlein purpura who presented with extensive skin rash, arthritis, and persistent abdominal pain. He was found to have small intestinal submucosal and subserosal haemorrhage on exploratory laparatomy. He developed pleural haemorrhages in the course of the disease, which to our knowledge has not been reported before in this disease.- - - - - - - - - - ranking = 0.85714285714286keywords = haemorrhage (Clic here for more details about this article) |