1/19. Aplastic anemia after mycoplasma pneumoniae infection: a report of two cases.Two very unusual cases of aplastic anemia complicating mycoplasma infection are described. Each patient had preexisting hematologic abnormalities at the time of the infection: reactive hemophagocytic syndrome in one, and autoimmune hemolytic anemia associated with cold autoantibodies in the other. This adds another entity to the protean manifestations of mycoplasma pneumoniae infection.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |
2/19. rhabdomyolysis associated with infection by mycoplasma pneumoniae: a case report.BACKGROUND. mycoplasma pneumoniae is responsible for approximately 20% of the cases of community-acquired pneumonia. The onset of respiratory symptoms is gradual and systemic complaints such as headache, malaise, arthalgias, and low-grade fever are frequently prominent. Extrapulmonary manifestations of M pneumoniae are common and hematologic (thrombocytopenia, splenomegaly, disseminated intravascular coagulation, hemolytic anemia), dermatologic (stevens-johnson syndrome), gastrointestinal (vomiting, diarrhea, pancreatitis), renal (interstitial nephritis, glomerulonephritis), cardiac (pericarditis, myocarditis, pericardial effusion) and central nervous system (meningitis, transverse myelitis, polyradiculopathy, cerebellar ataxia, sensorineural hearing loss) complications can occur. observation. We describe the case of an adolescent girl with massive rhabdomyolysis associated with an infection caused by M pneumoniae. We briefly review the differential diagnosis of a patient presenting with acute rhabdomyolysis and discuss the use of a new polymerase chain reaction-based assay for direct detection of M pneumoniae in throat swab specimens. CONCLUSION. Clinicians should be aware of a possible association between rhabdomyolysis and infection with M pneumoniae and should consider testing for M pneumoniae when they are presented with a patient with idiopathic rhabdomyolysis. The new polymerase chain reaction-based assay for detection of M pneumoniae is a more accurate and more efficient method than traditional culture.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |
3/19. Mycoplasma-pneumoniae-induced thrombotic thrombocytopenic purpura.Thrombotic thrombocytopenic purpura (TTP) is a fatal disease characterized by widespread platelet aggregation, hemolytic anemia and fever with renal and neurological involvement. Different factors have been associated with the development of TTP, e.g. infections, pregnancy, chemotherapy, drug therapy and bone marrow transplantation. Recent data imply that all these different causes may induce the disease by decreasing the activity of the plasma von willebrand factor-cleaving protease resulting in unusually large von willebrand factor multimers that later on initiate the cascade of TTP. In this communication, we present a unique association between infection with mycoplasma pneumoniae and TTP. We believe that the emergence of antibodies that cross-react with Mycoplasma and the protease might elucidate in this case the pathogenesis of TTP.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |
4/19. Severe hemolytic anemia and excessive leukocytosis masking mycoplasma pneumonia.The formation of cold agglutinins is frequently observed during mycoplasma pneumoniae infections. Nevertheless, severe hemolysis is exceptional. We report a case of life-threatening hemolytic anemia caused by M. pneumoniae. As the leucocyte count was excessively elevated, the differential diagnosis primarily comprised hematological malignancies. The presence of cold agglutinins indicated the correct diagnosis, which was confirmed by highly elevated levels of both IgG and IgM antibodies to M. pneumoniae and a chest X-ray suggestive of atypical pneumonia. The patient was treated with roxithromycin and showed a favorable recovery within ten days after admission. This case demonstrates that, even in patients with clinically mild pneumonia, M. pneumoniae may be the cause of severe anemia.- - - - - - - - - - ranking = 5keywords = hemolytic (Clic here for more details about this article) |
5/19. Severe bronchiolitis in acute mycoplasma pneumoniae infection.We report on a 17-year-old patient with severe bronchiolitis due to mycoplasma pneumoniae infection. Despite an early 10-day course of clarithromycin, she developed progressive dyspnea, cough, fever, and severe obstructive ventilatory impairment. Sixteen days after onset of the disease a severe hemolytic anemia developed with only cold agglutinins positive at serologic screening. Thoracoscopic lung biopsy revealed diffuse bronchiolitis with suppurative intrabronchiolar inflammation, lymphohistiocytic "cuffing" of the bronchioli, and foam cell aggregates within neighboring alveoli. The infiltrate consisted mainly of CD3 , CD8 lymphocytes and CD68 macrophages. The diagnosis of mycoplasma pneumoniae bronchiolitis was based on repeated complement fixation tests, which turned strongly positive only at day 74 after onset of the disease. Pulmonary function improved slowly under long-term prednisone treatment.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |
6/19. Corticosteroid therapy for hemolytic anemia and respiratory failure due to mycoplasma pneumoniae pneumonia.This is a report of hemolytic anemia and respiratory failure due to Mycopkisma pneumoniae pneumonia. His chest CT scans showed bilateral diffuse thickened bronchovascular bundles and emphysematous changes. The pulmonary function test supported the diagnosis of chronic obstructive pulmonary disease (COPD). He was diagnosed as coldagglunitin-associated hemolytic anemia and M. pneumonzae pneumonia in inapparent COPD. Corticosteroid administration was remarkabily effective for hemolytic anemia and beneficial for acute exacerbation of COPD.- - - - - - - - - - ranking = 7keywords = hemolytic (Clic here for more details about this article) |
7/19. Pneumonia due to mycoplasma pneumoniae with transient proteinuria.mycoplasma pneumoniae pneumonia can be associated with several systemic features. This report illustrates a case of M. pneumoniae pneumonia in an adult who recovered completely. Direct infection of the kidneys or an immunologic mechanism may have been the underlying cause. This patient also had simultaneous pharyngitis caused by group A beta-hemolytic streptococci. Various clinical possibilities with respect to pneumonia, pharyngitis, and proteinuria are briefly reviewed.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |
8/19. Cooling mattress induced acute hemolytic anemia.We have reported a patient with Mycoplasma pneumonia, cold agglutinins, and a hemolytic anemia which was probably secondary to vigorous treatment of hyperpyrexia by a cooling mattress. physicians caring for patients with Mycoplasma pneumonia should be alerted to the potential untoward effect of a cooling mattress on an individual with a high titer of cold agglutinins.- - - - - - - - - - ranking = 5keywords = hemolytic (Clic here for more details about this article) |
9/19. restless legs syndrome: association with streptococcal or mycoplasma infection.Group A beta-hemolytic streptococcal infections have been reported to cause neuropsychiatric symptoms, such as chorea, tics, and obsessive-compulsive disorder, presumably through autoimmune damage to basal ganglia. mycoplasma pneumoniae infections have also been reported to cause damage to the basal ganglia. restless legs syndrome is a movement disorder with focal restlessness, an irresistible desire to move, and exacerbation by long periods of sitting or lying. We present three children with transient restless legs syndrome-like symptoms possibly associated with group A beta-hemolytic streptococcal infection or mycoplasma pneumoniae infection. One of three patients had persistently elevated enzyme-linked immunosorbent optical density values against human caudate and putamen.- - - - - - - - - - ranking = 2keywords = hemolytic (Clic here for more details about this article) |
10/19. mycoplasma pneumoniae infection associated with hemolytic anemia--report of one case.Immune hemolytic anemia is a rare condition in childhood. Cold agglutinins have been implicated in the etiology of the hemolysis. However, cold agglutinins may occur in various infections, such as mycoplasma pneumoniae and infectious mononucleosis. In children, especially of preschool age, mycoplasma pneumoniae very commonly cause respiratory tract infection, but inducing an immune hemolytic anemia is exceptional. We present here a case of cold agglutinin-related severe hemolytic anemia (Hb = 3.8 gm/dl) secondary to mycoplasma pneumoniae infection who recovered completely after blood transfusion, intravenous immunoglobulin (IVIG) and medical treatment with erythromycin. It is suggested that even though very rare, mycoplasma pneumoniae may induce the occurrence of cold agglutinins and cause immune hemolytic anemia.- - - - - - - - - - ranking = 8keywords = hemolytic (Clic here for more details about this article) |
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