1/17. Synchronous oral leiomyosarcoma and squamous cell carcinoma.An unusual case of synchronous squamous cell carcinoma and leiomyosarcoma of the oral cavity is reported in a patient without any identified environmental risk or predisposing factors. The invasive squamous cell carcinoma involved the tongue, whereas the leiomyosarcoma was located in the soft palate. No immunostaining was found for human papillomavirus or Epstein-Barr virus, and in situ hybridization showed negativity for human papillomavirus dna within the tumor cells. Alterations of bcl -2, c-erb -b2 and Rb oncoproteins were not found immunohistochemically. Overexpression of p53 was detected by immunohistochemistry in both tumors, but p53 gene mutations were not found by polymerase chain reaction. Neither loss of heterozygosity of p53 nor microsatellite instability was detected in this patient. The smooth muscle nature of the leiomyosarcoma was confirmed by immunohistochemical methods. To our knowledge, synchronous smooth muscle and epithelial oral tumors have not previously been reported.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/17. Radiosensitive hemangiopericytoma in the soft palate.Hemangiopericytomas are uncommon neoplasms of vascular origin, and rarely arise in the pharynx. We report a case of a 78-year-old female with hemangiopericytoma in her soft palate exhibiting prominent radiosensitivity. Hemangiopericytomas are considered to be radioresistant and wide local excision is a treatment of choice, but their nature is widely variable. In treating aggressive hemangiopericytomas, radiation therapy can be selected.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/17. Multiple focal pigmented lesions in the maxillary tuberosity and hard palate: a unique display of intraoral junctional nevi.The pigmented conditions located in the oral cavity have a diverse genesis ranging from vascular lesions to exogenous and endogenous pigmentations. In this report we have documented the unusual occurrence of multiple intraoral junctional nevi in a patient. A review of the patient's past dental records revealed that 2 of these lesions were first noticed 8 years earlier; however, no efforts were made to identify the nature of the pigmentations. Removal of 4 lesions and subsequent histopathological analysis revealed the presence of junctional nevi. This case illustrates the importance of a thorough clinical and histological work-up when dealing with pigmented lesions in the oral cavity. The excision of all suspected oral nevi is warranted because they cannot be clinically differentiated from other pigmented lesions, including oral melanoma. In addition, the potential of junctional nevi to undergo malignant transformation in the oral cavity is undetermined.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/17. Recurrent parapharyngeal rhabdomyoma. Evidence of neoplastic nature of the tumor from cytogenetic study.A 64-year-old Caucasian male with a left parapharyngeal mass had a past medical history that was significant for excision of a benign rhabdomyoma of the soft palate 30 years previously. Then 25 years ago, the tumor recurred in the palate and retropharyngeal space on the left and was reexcised. Histologic examination of all three excisions showed adult rhabdomyoma. Ultrastructural and histochemical studies of the second excision of this tumor have been published previously. The present study included histologic, ultrastructural, immunohistochemical, and cytogenetic analyses. The histologic and ultrastructural features of the tumor were identical to those reported 25 years ago. Immunohistochemical studies demonstrated that the tumor cells were desmin and myoglobin positive and vimentin negative. Focal positivity for CD56 was also present. Intracellular inclusions in the tumor cells were strongly positive for desmin. Cytogenetic examination of short-term cultures of the tumor cells demonstrated clonal chromosome abnormalities in 60% of metaphases. The majority of cells showed a reciprocal translocation between chromosomes 15 and 17 as the sole abnormality. A minor clone was characterized by abnormalities of the long arm of chromosome 10. The presence of clonal structural chromosome abnormalities in extracardiac adult rhabdomyoma lends strong support to the idea that these rare tumors are true neoplasms rather than hamartomatous or regenerative lesions.- - - - - - - - - - ranking = 4keywords = nature (Clic here for more details about this article) |
5/17. Spitz nevus of the palate. Report of a case.A 4-year-old Japanese girl with a nonpigmented nodule on the anterior portion of the palate since birth is described. The overall microscopic appearance of the lesion was very similar to that of Spitz nevus of the skin. diagnosis of Spitz nevus (mixed epithelioid cell and spindle cell nevus) was made on the basis of the clinical and histologic criteria for differentiating this lesion from malignant melanomas and common compound nevi. Positive immunostaining of epithelioid and spindle cells for S-100 protein and neuron-specific enolase was also indicative of their nevocellular nature. review of the cases of Spitz nevus from the literature revealed that the present case most probably represents the first reported instance of this type of nevus in the oral cavity.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/17. Intraoral ultrasonic scanning as a diagnostic aid.Since ultrasonographic examination has the advantages of being non-invasive, rapid and easily reproducible, this technique can be a valuable aid in diagnosing oral lesions. However, the relatively large size of commercially available transducers and the acoustic attenuation by the air space within the oral cavity have been deterrents to the intraoral application of this technique. To resolve these problems a small intraoral transducer was developed and employed clinically in the diagnosis of oral soft tissue lesions. Performance tests reveal that this transducer provides 1mm axial resolution and 2 mm lateral resolution with a 30 mm focus. It can be easily employed within the oral cavity, using a small water bag or polymer gel as an acoustic coupling agent to the oral mucosa. Clinical application of this technique to oral soft tissue lesions allows definition of margins, size and location of lesions, and their relationship to adjacent structures, as well as discrimination between cystic, benign or malignant nature, by the sonic character. These results suggest that intraoral ultrasonic scanning can be useful in the diagnosis of oral soft tissue lesions.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/17. glycogen-rich clear cell carcinoma arising from minor salivary glands of the uvula. A case report.glycogen-rich clear cell carcinoma arising from minor salivary glands of the uvula in a 35-year-old woman is reported. This tumor was composed of nests and cords of clear cells containing cytoplasmic glycogen but no mucin. The epithelial nature of this lesion was obvious because of positive immunoreactivity for cytokeratin and epithelial membrane antigen, and the presence of immature lumina and intercellular spaces lined by many microvilli, associated with desmosomal junctions and basal lamina, as revealed by ultrastructural study. However, no myoepithelial cells could be detected. From these findings, it may be concluded that this tumor corresponds to glycogen-rich clear cell carcinoma (a variant of clear cell tumor), revealing glandular differentiation.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/17. Extracardiac rhabdomyoma: a report of two cases.Two case reports of extracardiac rhabdomyoma (adult type) are presented. The rare occurrence of extracardiac rhabdomyoma and its relatively benign nature makes a histological diagnosis very necessary, though often difficult to make. In both cases reported here, a diagnosis of extracardiac rhabdomyoma was given and treatment with local excision yielded good results. The importance of a histological diagnosis and treatment by only a local excision is stressed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
9/17. Squamous odontogenic tumour: review of the literature and a new case.Squamous odontogenic tumour (SOT) is a rare benign odontogenic neoplasm, apparently arising from rests of Malassez. It was first described in 1975 and since then only 17 cases have been recorded in the literature. A new, not previously reported, characteristic case of SOT is presented in connection with a review of the literature. It is concluded that the lesion occurs with equal frequency in the maxilla and mandible and now and then multifocally. Maxillary lesions seem to grow more aggressively than do mandibular ones. The symptoms are modest. SOT has a characteristic pathologic picture which differs decisively from ameloblastoma and which, in connection with its benign nature, warrants the classification of SOT. Although most cases have been treated by conservative surgical therapy without recurrence, there are cases, especially in the maxilla with diffuse lesions, which have required en bloc resection or hemimaxillectomy. The diagnostic problems are stressed and recommendations are made for the pathologist and the surgeon to pay attention to this rare but benign tumour.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
10/17. Juvenile spindle cell carcinoma.Spindle cell carcinoma is an uncommon variant of squamous cell carcinoma that is rarely seen in children. The spindle cell pattern is frequently confused with sarcomas. A case of spindle carcinoma in a 14-year-old boy is presented. He is the youngest patient, to the authors' knowledge, with spindle cell carcinoma of the maxilla. Electron microscopic examination is helpful to define the epithelial nature of the spindle cells and can be performed on formalin-fixed tissue. Electron microscopic examination is essential to formulate an optimal treatment plan.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
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