1/7. Fibrodysplasia ossificans progressiva and associated osteochondroma of the coronoid process in a child.The article reports the occurrence of osteochondroma in a fibrodysplasia ossificans progressiva patient. A 5-year-old boy presented with limited mouth opening and firm swelling of the right zygomatic complex area. The boy had bilateral hallux valgus of the great toes and heterotopic endochondral ossification of facial and neck regions. Associated osteochondroma of the coronoid process and aggressive heterotopic ossification of masticatory and neck muscles were found in response to traumatic injuries. Natural and clinical histories of fibrodysplasia ossificans progressiva were reviewed. An early diagnosis and avoidance of factors that aggravate ossification are key factors in reducing the expected degree of physical disabilities of patients. An early recognition of congenital skeletal deformities, early detection of abnormal ossification, and awareness of the disease by the involved physicians are important factors in the early diagnosis of the disease and in reducing any unnecessary trauma. Bone scintigrams and CT scans are effective noninvasive tools for an early detection of ossification and for monitoring the progression of the disease. Further investigation of its pathogenesis at a molecular level is important to understand better the nature of the disease and to develop an effective treatment protocol.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/7. Subungual melanoma with osteocartilaginous differentiation.Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/7. Extra-osseous osteochondroma-like soft tissue mass of the patello-femoral space.BACKGROUND: Extraskeletal cartilaginous tumors are uncommon. Osteochondromas usually arise from the metaphyseal region of the growing skeleton. CASE PRESENTATION: A 53 year old man presented with a three years history of anterior knee pain and inability to flex his knee more than 90 degrees . Clinical examination and imaging studies revealed a nodular calcific mass in the anterior portion of the knee, displacing the medial portion of the patellar tendon. Following excision, histopathology confirmed the diagnosis of extra-osseous osteochondroma-like soft tissue mass, with no recurrence 24 months after surgery. CONCLUSION: An integrated clinical-pathologic diagnosis helps to clarify the nature of extraskeletal cartilaginous tumors that can arise at unusual anatomic site. Complete local surgical excision is the management of choice.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/7. osteochondroma of the cervical spine.The localization of an osteochondroma in the spine is considered a rare occurrence. The authors describe the case of a 37 year-old woman with osteochondroma of the C2 neural arch involving the C1 spinous process. The woman came under observation because of severe loss of neck mobility and was subsequently diagnosed with osteochondroma. Of the preoperative examinations, MRI was more valuable than CT scan for defining the nature and extent of the tumor. Treatment consisted of complete posterior excision of the tumor, including the C1 spinous process and the C2 laminae up to the facets.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/7. osteochondroma of the coronoid process of the mandible. Report of a case showing histological evidence of neoplasia.A case of unilateral enlargement of the coronoid process of the mandible is presented. The patient, a 37-year-old woman complained of restricted mandibular movement and swelling in the left zygomatic region. Coronoidectomy was performed intraorally, producing improved mandibular movement. The specimen consisted of a large amount of cartilage and mature bone. Most of the cartilage showed a marked disturbance in endochondral ossification. The histopathological diagnosis was osteochondroma. A review of the basic nature of the disease in the reported cases is presented. The value of computed tomography in deciding on a surgical procedure is briefly mentioned.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/7. osteochondroma of the cervical spine. MR findings.We report two cases of osteochondroma in the region of the cervical spine. The magnetic resonance (MR) images well demonstrated the relationship of the tumor, the spinal cord, and adjacent soft tissue, but correct diagnosis by MR imaging was difficult in one patient due to unusual gadolinium enhancement. Computed tomography played an important role in these patients by demonstrating the exact origin and nature of the tumor.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/7. Paraarticular osteochondroma of the knee: report of 2 cases and review of the literature.Paraarticular osteochondromas are unusual osteocartilaginous tumors that arise in the soft tissue adjacent to a joint. Their pathogenesis and classification are controversial, and worrisome histologic features make the distinction from chondrosarcoma difficult on morphologic grounds alone. Two cases of paraarticular osteochondroma of the knee arising in patients 66 and 75 years of age are reported in this study. Although the exact biologic nature of these tumors is not well characterized, limited data suggest that they will behave in benign fashion, similar to soft tissue chondromas. Paraarticular osteochondromas should be recognized to avoid unnecessarily aggressive surgical management.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |