1/43. retinitis pigmentosa, nanophthalmos, and optic disc drusen: a case report.OBJECTIVE: Although the associations of retinitis pigmentosa (RP) with nanophthalmos/microphthalmos and RP with optic disc drusen have previously been recognized, the concurrence of all three features, as far as the authors are aware, has not previously been reported. DESIGN: Case report. RESULTS: The authors report a sporadic case of nanophthalmos, RP, and optic nerve drusen with the additional complication of chronic angle closure glaucoma. CONCLUSIONS: Visual loss may be secondary to the complications of nanophthalmos, RP, or optic nerve drusen. Chronic angle closure may be caused by choroidal effusion with serous retinal detachment, which may, in turn, cause a pseudo-RP picture. It is therefore important to recognize the possible association of true RP with nanophthalmos as a cause for visual deterioration.- - - - - - - - - - ranking = 1keywords = optic (Clic here for more details about this article) |
2/43. Anterior ischaemic optic neuropathy in a patient with optic disc drusen.BACKGROUND: Although visual field defects are well-known complications of optic disc drusen, reduction in visual acuity with this condition is rare. METHOD/RESULTS: We report on a 68-year-old male with bilateral optic disc drusen who presented with monocular loss of vision in the right eye associated with an inferior altitudinal visual field defect and signs consistent with acute anterior ischaemic optic neuropathy, confirmed on fluorescein angiography. He also had a left inferior nasal step, but no evidence of glaucomatous cupping. The disc drusen were documented clinically and on B scan ultrasound and computed tomography. CONCLUSIONS: The diagnosis of acute anterior ischaemic optic neuropathy should be considered in patients with optic disc drusen who present with reduced visual acuity, particularly when the visual loss has been acute and non-progressive and is associated with altitudinal field loss and characteristic fluorescein angiography signs.- - - - - - - - - - ranking = 1.8571428571429keywords = optic (Clic here for more details about this article) |
3/43. Optic neuropathy following amiodarone therapy.Ocular changes during treatment with amiodarone are almost universal but are rarely serious. In this article we describe three patients from a single electrophysiology practice in whom optic neuropathy developed during treatment with amiodarone. All three patients were more than 65 years of age. The doses of amiodarone ranged from 100 to 400 mg/day, and the time intervals between the initiation of the amiodarone therapy and the appearance of first symptoms of optic neuropathy were 5 to 19 months. Two patients had bilateral involvement, and one had only unilateral involvement. Whether this result was due solely to amiodarone therapy, to the underlying poor health of these patients, or to the combination of these two factors is uncertain. These findings prompt us to recommend that all patients who receive amiodarone undergo complete ophthalmologic examinations, including careful evaluation of the ocular fundus regularly during such therapy. No randomized study had been undertaken to determine the true incidence of complications associated with this medication.- - - - - - - - - - ranking = 0.28571428571429keywords = optic (Clic here for more details about this article) |
4/43. Afferent pupillary defect associated with optic nerve head drusen.BACKGROUND: optic nerve head drusen (ONHD) are a relatively uncommon finding with an estimated prevalence of anywhere from 0.3% to 2%. Reports of relative afferent pupillary defects (RAPDs) associated with ONHD are scarce. CASE REPORT: A patient with an RAPD was found to have ONHD as the only apparent etiology of the RAPD. The various diagnostic tests relevant to the case, the differential diagnosis, and the pathological features of ONHD are discussed. CONCLUSIONS: It is important for the clinician to consider an RAPD as a possible pathological feature of ONHD--especially with an asymmetric presentation.- - - - - - - - - - ranking = 0.57142857142857keywords = optic (Clic here for more details about this article) |
5/43. Acquired and progressive retinal nerve fiber layer myelination in an adolescent.PURPOSE: To report the onset and progression of retinal nerve fiber layer myelination in an adolescent patient. methods: Case report. RESULTS: A 7-year-old male was found to have myelination of the retinal nerve fiber layer in the left eye. When he was reexamined at age 14 years, he was found to have new myelination in the right eye, progression of the myelination in the left eye, and bilateral optic nerve drusen. CONCLUSION: Retinal nerve fiber layer myelination can occur spontaneously in adolescence, progress in adolescence, and be associated with optic nerve drusen.- - - - - - - - - - ranking = 0.28571428571429keywords = optic (Clic here for more details about this article) |
6/43. Bilateral anterior ischaemic optic neuropathy due to optic disc drusen.PURPOSE: To report a case of bilateral anterior ischaemic optic neuropathy due to buried optic disc drusen. methods: Case report. RESULTS: A 64-year-old man presented with swollen optic discs and features suggestive of anterior ischaemic optic neuropathy (AION) in the left and right eye on two separate occasions ten months apart. Detailed ocular examination at presentation and systemic investigations did not reveal an underlying cause for the AION. At a later follow-up, optic disc drusen were noted in both eyes as partial optic atrophy had set in. This was confirmed by ultrasound B scan and demonstration of autofluorescence. CONCLUSIONS: In patients presenting with AION uncommon underlying causes must be considered. Routine ultrasound B scan at presentation can easily establish or exclude optic disc drusen as an underlying cause.- - - - - - - - - - ranking = 2.1428571428571keywords = optic (Clic here for more details about this article) |
7/43. Two differing presentations of optic nerve head drusen.BACKGROUND: optic nerve head drusen was recognized histologically in 1858 by Heinrich Muller The majority of optic nerve head drusen cases have been benign in nature. However, optic nerve head drusen can be visually devastating. case reports: Two patients were diagnosed with optic nerve head drusen. They were similar in age and each had a best-corrected visual acuity of 20/20 OU. Although the diagnosis was the same, the disease affected each person very differently. One is currently asymptomatic; the other is legally blind secondary to severely constricted visual fields. These cases demonstrate the diversity of visual effects produced by optic nerve head drusen. Appropriate ocular workup, including visual fields, B-scan ultrasonography, computed tomography, and other tests, are presented. CONCLUSION: There is no existing treatment for optic nerve head drusen. Proper diagnosis and patient education is the best-available modality of care. patients need to be aware of potential complications which, while rare, can affect vision. Visual-field testing can aid in monitoring for subtle changes in vision.- - - - - - - - - - ranking = 1.2857142857143keywords = optic (Clic here for more details about this article) |
8/43. I don't need my glasses, but...A 24-year old man complained of decreased vision in his right eye for 1 week. Examination revealed a subtle right optic neuropathy. Fundoscopy showed bilateral buried drusen, which were confirmed with B-scan ultrasonography. An MRI was normal.- - - - - - - - - - ranking = 0.14285714285714keywords = optic (Clic here for more details about this article) |
9/43. optic disk drusen, peripapillary choroidal neovascularization, and poems syndrome.PURPOSE: To report the case of a 64-year-old woman with peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, Castleman disease, optic nerve drusen, and peripapillary choroidal neovascularization. methods: Interventional case report. Clinical practice. RESULTS: Laser photocoagulation resolved the peripapillary choroidal neovascularization. CONCLUSION: This is the first documented case of optic disk drusen and peripapillary choroidal neovascularization associated with POEMS.- - - - - - - - - - ranking = 0.51704253520874keywords = optic disk, optic, disk (Clic here for more details about this article) |
10/43. Optic disc drusen, angioid streaks, and mottled fundus in various combinations in a Sicilian family.BACKGROUND: We describe a Sicilian family in which optic disc drusen, angioid streaks, and mottled fundus--without dermatological signs of pseudoxanthoma elasticum (PXE)--are present in various combinations and segregate as an autosomal dominant trait. Since these ocular manifestations can be part of the clinical signs of PXE, we examined the possible involvement of a mutation in the ABCC6 gene, which is known to be responsible for PXE. methods: Linkage analysis was performed with both intragenic and flanking markers. We used marker D16B9722 and a single-nucleotide polymorphism located in exon 15 of the ABCC6 gene. lod score values were calculated on the assumption of a gene frequency of 0.0001 and both complete penetrance and reduced penetrance (90%), with theta values between 0.0 and 0.4. RESULTS: lod score values excluded the involvement of the ABCC6 gene. CONCLUSIONS: The dominant transmission of optic disc drusen, mottled fundus, and angioid streaks in this family is not due to alterations in the ABCC6 gene.- - - - - - - - - - ranking = 0.28571428571429keywords = optic (Clic here for more details about this article) |
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