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1/10. Rare case of naso-oral fistula with extensive osteocartilaginous necrosis secondary to cocaine abuse: review of otorhinolaryngological presentations in cocaine addicts.

    We report what we believe to be only the 10th case of palatal necrosis secondary to cocaine abuse in a 33-year-old female patient. Extensive necrosis also involved the cartilaginous and bony septum and paranasal sinuses. Following exclusion of other mid-line destructive diseases her treatment involved saline douches and cessation of cocaine. She remains under review within the department with no evidence of progressive disease. We present a review of the other nine cases of palatal necrosis reported in the world literature and demonstrate a greater incidence in female users. The various presenting conditions of cocaine abuse encountered within the head and neck region by the otorhinolaryngologist are then discussed.
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ranking = 1
keywords = world
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2/10. New World leishmaniasis from spain.

    A 69 year old man living in spain contracted mucocutaneous leishmaniasis involving the nose. The infecting organism was leishmania infantum, which only rarely causes the New World form of the disease. The source of infection was probably a neighbour's dog. The patient began treatment with liposomal amphotericin b but died of pneumonia two months later.
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ranking = 41167.872131135
keywords = leishmaniasis
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3/10. Identification of Leishmania from mucosal leishmaniasis by recombinant dna probes.

    Three cases of mucosal leishmaniasis are described. parasites isolated from mucosal lesions were identified by Southern blot analysis of their genomic deoxyribonucleic acids (DNAs) using recombinant DNA probe pDK20. parasites from 2 patients were identified as leishmania donovani s.l. One of the patients had pure mucosal lesions, while in the second patient there was dissemination of the parasite to other organs. The spectrum of the disease caused by L. donovani is discussed. The parasite from the third patient was identified as L. major.
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ranking = 41167.872131135
keywords = leishmaniasis
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4/10. Nasal histoplasmosis in the acquired immunodeficiency syndrome.

    Disseminated histoplasmosis is a disease with a high case-fatality rate, especially in patients with the acquired immunodeficiency syndrome (AIDS). The disease can occur in various sites, such as the lungs, eyes, oral cavity, larynx, nervous system, gastrointestinal tract and, more rarely, the nasal sinus region. It is a cosmopolitan mycosis with a high prevalence in Brazil. Nasal manifestation of the disease is rare, with only three cases reported in the literature, but it is part of the differential diagnosis for other granulomatous diseases, such as Wegener's granulomatosis, tegumentary leishmaniasis and nasal lymphoma. The authors of this study present a literature review and report a case of nasal histoplasmosis in a patient with AIDS. No record of such an aggressive presentation has been reported previously in the literature.
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ranking = 8233.574426227
keywords = leishmaniasis
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5/10. Mucocutaneous leishmaniasis due to Leishmania (Leishmania) infantum: biochemical characterization.

    A vegetative mass in the right nasal cavity of a 62-year-old man from Palma de Mallorca, spain, was found to be due to Leishmania. The organism was isolated in culture and characterized by in situ hybridization, Southern blot hybridization, and isoenzyme analysis; it was thus demonstrated to be the most common enzyme variant 1 (MON 1) of Leishmania (Leishmania) infantum.
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ranking = 32934.297704908
keywords = leishmaniasis
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6/10. Trigeminal trophic syndrome.

    Trigeminal trophic syndrome is an unusual condition also known as trigeminal neurotrophic ulceration or trigeminal neuropathy with nasal ulceration. The diagnosis is suggested when ulceration of the face, especially of the ala nasi, occurs in a dermatome of the trigeminal nerve that has been rendered anesthetic by a surgical or other process involving the trigeminal nerve or its central sensory connections. A history of paresthesias and self-induced trauma to the area further support the diagnosis. Neurological deficits causing trigeminal trophic syndrome may result from surgical trigeminal ablation, vascular disorders and infarction of the brainstem, acoustic neuroma, postencephalitic parkinsonism, and syringobulbia. The following etiologies of nasal ulceration should be excluded: postsurgical herpetic reactivation and ulceration, syphilis, leishmaniasis, leprous trigeminal neuritis, yaws, blastomycosis, paracoccidioidomycosis, lethal midline granuloma, pyoderma gangrenosum, Wegener's granulomatosis, and basal cell carcinoma. In the case reported here, the diagnosis of TTS was made primarily as a result of previous experience with the syndrome, underscoring the importance of physician recognition of this unusual disorder.
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ranking = 8233.574426227
keywords = leishmaniasis
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7/10. Rhinophycomycosis entomophthorae.

    Rhinophycomycosis entomophthorae is a variant type of subcutaneous phycomycosis of the face that is caused by entomophthora coronata. The case we describe was the first patient reported in the world literature, to our knowledge. His infection reappeared after an extended dormant period. Although his condition exhibited an early partial response to surgical and medical management, the condition became refractory to treatment.
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ranking = 1
keywords = world
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8/10. Nasal leishmaniasis.

    leishmaniasis is an uncommon condition in Western europe, except around the Mediterranean coast. However, it may occasionally be seen in the United Kingdom, in patients who acquired the infection in foreign lands. An unusual case of localized cutaneous leishmaniasis recidiva affecting the nose after septal surgery is presented.
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ranking = 41167.872131135
keywords = leishmaniasis
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9/10. leishmania braziliensis presenting as a granulomatous lesion of the nasal septum mucosa.

    Differential diagnosis of granulomatous lesions of the nasal mucosa is difficult. One of the possible causes is an infection with leishmania braziliensis as reported in this case. Therefore leishmaniasis should be included in the differential diagnosis of granulomatous lesions of the nasal mucosa in patients who have travelled to endemic areas.
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ranking = 8233.574426227
keywords = leishmaniasis
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10/10. American cutaneous leishmaniasis due to Leishmania (Viannia) guyanensis as an initial clinical presentation of human immunodeficiency virus infection.

    The authors present the first report of Leishmania (Viannia) guyanensis (L.(V.) guyanenesis) associated with human immunodeficiency virus (hiv) in a Brazilian heterosexual man. It is also the first case of hiv infection associated with American cutaneous leishmaniasis in Brazilian Western Amazonia. The patient had cutaneous and mucous lesions with a negative montenegro skin test. Histopathology showed large numbers of amastigotes, even in a lesion which had clinically healed. L.(V.) guyanenesis was typed by an immunoenzymatic technique. Various therapies were attempted, but the patient relapsed after each episode of treatment.
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ranking = 41167.872131135
keywords = leishmaniasis
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