1/102. guillain-barre syndrome following malaria.Two adult males were admitted with acute are flexic quadriplegia and bifacial and bulbar weakness 2 weeks after an acute episode of malaria, one due to Plasmodium falciparum infection (patient 1) and the other due to plasmodium vivax (patient 2). cerebrospinal fluid analysis and nerve conduction studies confirmed the diagnosis of guillain-barre syndrome (GBS). Patient 1 progressed to develop respiratory paralysis and required mechanical ventilation. He received intravenous immunoglobulins for the GBS and made a complete recovery in 6 weeks. A review of 11 cases of GBS (nine previously reported and the present two) revealed that eight patients had preceding falciparum malaria and three had vivax infection. All but two patients had distal symmetric sensory deficits. Paralysis was mild in seven cases (three due to P. vivax and four due to P. falciparum) and recovered completely in 2-6 weeks without any specific treatment. Four patients with falciparum malaria developed severe paralysis with respiratory failure, and three patients died. One patient who received intravenous immunoglobulins recovered completely (patient 1 in this report).- - - - - - - - - - ranking = 1keywords = infection (Clic here for more details about this article) |
2/102. Rare quadruple malaria infection in Irian Jaya indonesia.We report an exceptional finding from a blood slide collected in a remote area in the western half of new guinea Island (Irian Jaya Province, indonesia). One adolescent patient was found patently coinfected with all 4 known human malaria species, plasmodium falciparum, plasmodium vivax, plasmodium malariae, and plasmodium ovale. Diagnostic erythrocytic stages of all 4 species were clearly seen in the peripheral blood. A nested polymerase chain reaction, using species-specific primer pairs to detect dna, helped substantiate this finding. Previous reports from africa, thailand, and new guinea have detected all 4 species in a population but not simultaneously in an individual with a patent, microscopically detectable infection. We believe this quadruple infection represents the first reported natural case of all 4 human malaria parasites observed concurrently in the peripheral blood from a single Giemsa-stained slide.- - - - - - - - - - ranking = 3keywords = infection (Clic here for more details about this article) |
3/102. Transmission of malaria tertiana by multi-organ donation.In this report, transmission of malaria via a liver, a kidney, and possibly a heart allograft from a single donor is described. The donor had immigrated from cameroon to germany 18 months before, but had no clinical signs of active malaria infection. The liver transplant recipient and one of the two kidney transplant patients developed febrile illness with the appearance of plasmodium vivax in blood smears 5 and 6 wk after transplantation, respectively. In the heart transplant recipient, a subclinical malaria infection was suspected based on a rise of malaria antibodies late after transplantation, whereas the recipient of the second kidney allograft had no clinical or laboratory evidence of malaria. Both liver and kidney recipients with active malaria responded to medical treatment. However, the liver transplant patient developed progressive cholestasis and died 5 months after transplantation from liver failure possibly due to side effects of the malaria medication. Other cases of malaria in solid organ recipients are briefly reviewed.- - - - - - - - - - ranking = 1keywords = infection (Clic here for more details about this article) |
4/102. Malaria complicating neoplastic disease.Two patients with neoplastic disease had transfusion-induced malaria. In a patient with acute myelogenous leukemia infected with plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection. In a splenectomized patient with metastatic carcinoma of the colon, P malariae infection was associated with a fulminant course simulating cerebral malaria. Despite delay in diagnosis, both patients responded dramatically to antimalarial chemotherapy and both developed appreciable antibody responses.- - - - - - - - - - ranking = 1keywords = infection (Clic here for more details about this article) |
5/102. Erythrocyte Fy antigen phenotyping helps differentiate so-called benign tertian malarias.Isolated cases of malaria are increasing in frequency in nonendemic countries. blood film examination remains a mainstay of diagnosis of these sporadic cases because immunologic and molecular methods are unavailable, expensive, and problematic. Two tertian malarial species, plasmodium vivax and plasmodium ovale, may appear to be similar morphologically. plasmodium ovale infection is infrequent, and misdiagnosis of this species is common. plasmodium vivax infection can be ruled out, however, if a patient's erythrocytes phenotype as Fy(a-b-), because these cells completely resist entry by the latter species.- - - - - - - - - - ranking = 1keywords = infection (Clic here for more details about this article) |
6/102. Drug-induced acute malaria.The case of an elderly woman with asymptomatic P. malariae infection that acutely reactivated after 45 y of latency following treatment with chlorambucil and methylprednisolone is reported. Only 1 similar case with methotrexate-induced acute malaria has been reported in the English literature thus far.- - - - - - - - - - ranking = 0.5keywords = infection (Clic here for more details about this article) |
7/102. Observations on malaria in Indonesian timor.Malaria parasitemias were found in 35% of 520 individuals from a village in Timor, indonesia. plasmodium falciparum accounted for 80% of infections. The existence of P. ovale in Timor is reported for the first time. The WHO Standard Field Test for drug resistance did not reveal significant resistance of P. falciparum or P. vivax to chloroquine.- - - - - - - - - - ranking = 0.5keywords = infection (Clic here for more details about this article) |
8/102. Application of the indirect fluorescent antibody method in a study of malaria endemicity in Mato Grosso, brazil.Four surveys of malaria endemicity were conducted in the Cuiaba Sector of Mato Grosso State, brazil, at 6-month intervals during the period April 1970 to September 1971; during April 1970 a survey was also conducted in the Campo Grande Sector. Over 4,000 dual specimens--blood films for parasite diagnosis and filter paper blood spots for determination of fluorescent antibody (IFA) response--were collected from the general population, including school populations whenever possible. Parasitologic examinations yielded positivity rates ranging from 0.8 to 2.3%. In the Cuiaba Sector, sero-positives (larger than or equal to 1:20) ranged from 9.3 to 13.6%; in the survey in the Campo Grande Sector only 4.3% of the specimens were positive. There was an expected increase in IFA response with age in both the proportion of positives and mean maximum titers. In the Cuiaba surveys 75 to 91% of the maximum positive responses were to the plasmodium falciparum antigen, while in Campo Grande only 46% of the maximum titers were for P. falciparum. The wide differences in malaria endemicity observed within the Cuiaba Secctor were attributed to differences in climate, geography, and degree of development of the several regions. A study of surveillance reports from 1966 through the survey dates revealed that the high rates of infection seen often resulted from detection activities in the larger cities and probably represented cases imported from endemic areas to the north and west. In order to interpret accurately the endemicity of malaria in an area and, thus, determine the necessity for introduction or continuation of control measures, thorough epidemiologic studies are necessary. The addition of a serologic method to normal surveillance can increase the accuracy of interpretation.- - - - - - - - - - ranking = 0.5keywords = infection (Clic here for more details about this article) |
9/102. Probable chloroquine-resistant plasmodium falciparum malaria from mozambique A case report.A female patient with plasmodium falciparum malaria apparently resistant to chloroquine is descirbed. She had recently returned from mozambique, which may prove to be a new endemic are with resistant strains. The infection was successfully treated with quinine.- - - - - - - - - - ranking = 0.5keywords = infection (Clic here for more details about this article) |
10/102. Fatal falciparum malaria among narcotic injectors.Eleven narcotic injectors from a prison in Saigon were hospitalized with falciparum malaria. coma and intense parasitemia were common and eight patients died soon after admission. Two of three autopsied cases also had purulent pulmonary infections. No non-addicted prisoners were hospitalized for malaria. Nine more unsuspected falciparum infections were found among 29 other addicts in the prison. The clustering of malaria infections among narcotic injectors who had not been in malarious areas indicates that the malaria was transmitted by the common use of needles and syringes. Cerebral malaria in an addict may be misdiagnosed as drug intoxication. Malaria surveillance is recommended for the increasing addict population in the cities of Southeast asia.- - - - - - - - - - ranking = 1.5keywords = infection (Clic here for more details about this article) |
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