1/10. Ocular complications of stevens-johnson syndrome and toxic epidermal necrolysis in patients with AIDS.Recent reports suggest that acquired immunodeficiency syndrome (AIDS) patients are at higher risk of developing mucocutaneous reactions such as toxic epidermal necrolysis and stevens-johnson syndrome (SJS). Resultant dry eye may be further exacerbated by human immunodeficiency virus (hiv) related lacrimal gland dysfunction and lead to a chronic keratoconjunctivitis. We report one patient with AIDS and toxic epidermal necrolysis and two patients with AIDS and SJS who developed severe dry eye misdiagnosed as infectious keratoconjunctivitis. Cicatrizing mucocutaneous reactions should be suspected in AIDS patients and the dry eye treated to control symptoms and prevent complications.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/10. Corneal ulcers associated with goldenhar syndrome.Two patients with goldenhar syndrome developed corneal ulcers. Previous acid burn of the cornea and prolonged topical corticosteroid administration occurred in Patient 1. Predisposing ocular anomalies in patients with goldenhar syndrome include corneal hypesthesia; keratoconjunctivitis sicca, and exposure secondary to eyelid colobomas, lacrimal gland and duct anomalies, dermoids and lipodermoids, and neurologic deficits. Serious ocular morbidity may be prevented by searching for and adequately treating these predisposing factors. It is possible that embryonic events contribute to ocular complications in goldenhar syndrome, in part, by causing hypoplasia or abnormal function of the trigeminal and facial nerves.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
3/10. Sebaceous carcinoma of the eyelid masquerading as superior limbic keratoconjunctivitis.A 49-year-old woman had been treated for 18 months for superior limbic keratoconjunctivitis of the right eye. Pathologic examination of a biopsy specimen of the superior perilimbal conjunctiva disclosed intraepithelial carcinoma of sebaceous gland origin. Because of the extensive involvement of the conjunctival epithelium by tumor, a subtotal orbital exenteration was performed. To our knowledge, this is the first report of sebaceous carcinoma masquerading as superior limbic keratoconjunctivitis.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
4/10. Sicca complex and cholangiostatic jaundice in two members of a family probably caused by thiabendazole.An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. sjogren's syndrome is an autoimmune disease and presents many immune mechanism aberrancies. An association between autoimmune liver disease and sicca complex has been reported. Labeled mitochondrial antibodies bound to the parotid duct have been noted in patients with autoimmune cholangiostatic jaundice and such antibodies may be similar to the antibody against salivary duct found in sjogren's syndrome. It is suggested that in these two patients, thiabendazole may have acted as a hapten and by binding to the body protein induced the production of autoantibodies which may have acted against the biliary epithelium, the salivary duct epithelium, and the lacrimal gland ducts.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/10. A case of sicca syndrome due to primary amyloidosis.We report the rare occurrence of sicca syndrome associated with primary amyloidosis. A 63-year-old man with apparent keratoconjunctivitis sicca and xerostomia died of the cardiac failure. Neither sialography nor labial gland biopsy revealed findings compatible with sjogren's syndrome. Macroglobulinemia and a positive Bence-Jones protein were noted in urine testing. Amyloid deposition was demonstrated by congo red staining on biopsied rectal tissues, and by typical birefringence under polarized light microscopy. At autopsy, the amyloid deposition was identified histochemically in the submandibular gland and the minor salivary glands of oral cavity.- - - - - - - - - - ranking = 3keywords = gland (Clic here for more details about this article) |
6/10. Marsupialization of a lacrimal gland cyst.A lacrimal gland cyst developed as a late complication of stevens-johnson syndrome. The mass produced mechanical ptosis and became secondarily infected. Obstruction of lacrimal secretions contributed to a quantitative tear deficiency and epithelial erosions of the cornea. The mass and the keratoconjunctivitis sicca were successfully managed by marsupialization of the cyst wall.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
7/10. keratoconjunctivitis sicca following excision of a dermolipoma of the lacrimal gland.A 20-year-old woman with subconjunctival mass of the superotemporal region of the globe was operated upon. The mass was found to be a dermolipoma of the lacrimal gland. The removal of the mass caused severe keratoconjunctivitis sicca, which could only be helped with frequent applications of artificial tears.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
8/10. Absent meibomian glands: a marker for EEC syndrome.A patient with a 20 year history of severe keratoconjunctivitis of unknown origin was found, on assessment at a blepharitis clinic, to have complete absence of meibomian glands. Further examination revealed the features of EEC syndrome. To our knowledge, this is the only case to have been diagnosed in this way. The ocular complications of EEC syndrome and other ectodermal dysplasias are reviewed.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
9/10. lichen planus and Sjogren-type sicca syndrome in a patient with chronic hepatitis c.We report a 54-year-old Japanese male with lichen planus and Sjogren-type sicca syndrome, accompanied by the latent complication of chronic hepatitis c. The patient first showed erythematous and erosive lesions with white irregular striae in the buccal mucous membrane, and blepharitis and hyperemia of conjunctiva in his eyes. He later had two small erosions on the glans penis, and flat-topped violaceous papules on the dorsa manus and nape. A biopsy specimen of the lower lip lesion demonstrated a lichenoid tissue reaction at the basement membrane zone, and lymphocytic focal accumulations in the salivary glands. Immunohistochemical study of this specimen revealed CD45RO- (T) cells associated with the expression of hla-dr antigens predominantly in both the lichenoid tissue reaction and the lymphocytic sialadenitis. Objective keratoconjunctivitis sicca was confirmed by the Schirmer and Rose-Bengal tests. Anti-dna antibody was positive; however anti-SS-A, and anti-SS-B antibodies were negative. Increased levels of transaminase enzymes, TTT, ZTT, and IgG were observed in first laboratory examinations; thereafter, antihepatitis C virus (HCV) antibodies and HCV-rna were detected. The high serum amylase level, in which salivary amylase predominated, was normalized by etretinate therapy in parallel with the clinical improvement of the oral LP lesions. Our case is considered to support the hypothesis that an etiologic association may be present among lichen planus, sjogren's syndrome, and chronic hepatitis c.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
10/10. Chronic keratoconjunctivitis associated with congenital dyskeratosis and erythrokeratodermia variablis. Two rare genodermatoses.OBJECTIVE: The purpose of the study was to report the ocular manifestations and immunohistopathologic description of two rare forms of genodermatosis: congenital dyskeratosis (CD) and erythrokeratodermia variabilis (EKV). DESIGN: case reports. PARTICIPANTS: Two patients with CD and EKV presenting with chronic keratoconjunctivitis were studied. INTERVENTION: Clinical photography to show ocular manifestations and dermatologic findings was performed. Conjunctival biopsy was performed to determine the histopathology and immunohistopathology. RESULTS: In the patient with EKV, the eyelid skin was dry, erythematous, and thickened. The lid margins showed plugging of some of the meibomian glands, madarosis, and occasional trichiasis. The epibulbar conjunctiva was injected and had a moderate papillary reaction. Both corneas had pronounced vascularization and stromal scarring. Conjunctival biopsy results disclosed a striking number of degranulating mast cells and moderate numbers of plasma cells. Immunohistopathology showed pronounced immunoglobulin g (IgG)-positive cells in the stroma and immunoglobulin a (IgA) positivity in the epithelium. There was scattered immunoglobulin m (IgM) and moderate C3 and C4 positivity in the stroma. In CD, the patient had keratinized lid margins, entropion formation, trichiasis, cicatrizing conjunctivitis, and symblephra formation. The corneal surface was keratinized, with deep and superficial vascularization. Conjunctival biopsy specimens showed pronounced epithelial keratinization and squamous metaplasia. Degranulating mast cells and eosinophils were prominent in the stroma. Immunohistopathology showed C4 and immunoglobulin d positivity on the keratinized epithelial surface with rare foci of immunoglobulin e-positive cells. Basal epithelial cells were positive for IgA and IgG, and a large number of IgA and IgG plasma cells were present in the substantia propria. CONCLUSION: To the authors' knowledge, these case reports represent the first clinical description of the ocular manifestation of EKV and the first immunohistopathologic description of the affected conjunctiva in EKV and CD, both of which should be considered in the differential diagnosis of genodermatosis associated with chronic keratoconjunctivitis.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
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