11/78. Neonatal hyperthyroidism following intrauterine hypothyroidism.An infant, whose mother was treated for thyrotoxicosis during pregnancy, appeared normal at birth, but laboratory data were indicative of hypothyroidism. On the sixth day of life the infant had clinical and laboratory evidence of hyperthyroidism. A plan of management is proposed for infants born to thyrotoxic mothers.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
12/78. hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder.We present a case of severe hyperemesis gravidarum (HG) associated with thyrotoxicosis in a woman with a past history of an eating disorder. She had developed persistent HG from early pregnancy until about at the end of the second trimester with a body loss of 14 kg. Total parenteral nutrition was effective in alleviateing HG. It is suggested that even a past history of an eating disorder could be at risk of developing HG.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
13/78. lingual thyroid and hyperthyroidism: a new case and review of the literature.lingual thyroid is the result of a defective migration of the thyroid anlage occurring between the 3rd and 7th week of gestation. Whereas mutations in the transcription factor-2 (TTF-2) and PAX8 and in the TSH receptor genes (TSH-R) have been reported in a minority of patients with thyroid dysgenesis, the etiopathogeny of the majority of cases, and in particular of thyroid ectopy, remains unclear. The majority of patients with thyroid ectopy are asymptomatic, but obstructive symptoms as well as hypothyroidism have been observed. hyperthyroidism is an exceptionally rare finding. To our knowledge, only 2 cases have been reported in the literature to date. Herein, we describe an unusual case of thyrotoxicosis related to a nodular lesion in a lingual thyroid. Treatment consisted in restoration of a euthyroid state with thionamide followed by surgical removal of the ectopic gland. The underlying molecular cause of the ectopic lingual thyroid and the toxic adenoma in this case could not be identified. We speculate that abnormally early differentiation of the thyroid gland could interfere with the migration process, a hypothesis yet to be confirmed.- - - - - - - - - - ranking = 0.53145129387589keywords = gestation (Clic here for more details about this article) |
14/78. hyperthyroidism in the setting of gestational trophoblastic disease.We report the case of a 27-year-old woman who presented with palpitations, hyperemesis, and weight loss. The patient was found to have laboratory values consistent with hyperthyroidism. A serum pregnancy test was positive for an estimated 8-week gestation. After an ultrasound diagnosis of a molar pregnancy, the patient underwent a uterine evacuation with subsequent resolution of her hyperthyroid status. We provide herein the details of this rarely documented presentation of hyperthyroidism in the setting of gestational trophoblastic disease.- - - - - - - - - - ranking = 5.1887077632554keywords = pregnancy, gestation (Clic here for more details about this article) |
15/78. Acute renal failure in association with severe hyperemesis gravidarum.BACKGROUND: Severe hyperemesis gravidarum is a rare but potentially devastating complication of pregnancy. Among its many potential complications are dehydration, electrolyte imbalance, malnutrition, wernicke encephalopathy, and compromised renal function. CASE: We report the case of a 21-year-old woman at 15 weeks' gestation presenting to the emergency department with severe hyperemesis gravidarum associated with acute renal failure. Her initial serum creatinine and blood urea nitrogen were 10.7 mg/dL and 171 mg/dL, respectively. The patient underwent daily hemodialysis for 5 days with subsequent return of renal function to normal. CONCLUSION: women with severe hyperemesis gravidarum may be at risk for acute renal failure caused by severe intravascular volume depletion.- - - - - - - - - - ranking = 1.5314512938759keywords = pregnancy, gestation (Clic here for more details about this article) |
16/78. Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.We report the case of a 27-year-old woman with hyperthyroidism during pregnancy. Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ). The remaining pregnancy, delivery and follow-up period were uneventful for the mother and her offspring. Antithyroid treatment during pregnancy should allow the use not only of PTU but also of CBZ and methimazole.- - - - - - - - - - ranking = 8keywords = pregnancy (Clic here for more details about this article) |
17/78. Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester.We report two infants with gastrointestinal anomalies: one with esophageal atresia and tracheo-esophageal fistula and the other with biliary tree atresia, born to hyperthyroid women diagnosed and treated with methimazole after 14 weeks' gestation. Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.- - - - - - - - - - ranking = 0.53145129387589keywords = gestation (Clic here for more details about this article) |
18/78. molar pregnancy and hyperthyroidism in a 13 year-old girl.A 13 year-old girl presented with secondary amenorrhea, vaginal bleeding and dyspnea. hyperthyroidism was diagnosed based on clinical symptoms and thyroid function test. Ultrasonographic findings and tissue histology from curettage were consistent with a hydatidiform mole. She reached clinical euthyroidism 2 weeks after uterine curettage and propylthiouracil treatment. The diagnosis of putative adult diseases in pediatric patients should not be ruled out.- - - - - - - - - - ranking = 4keywords = pregnancy (Clic here for more details about this article) |
19/78. esophageal atresia and tracheoesophageal fistula in two infants born to hyperthyroid women receiving methimazole (Tapazol) during pregnancy.We report on 2 newborn infants with esophageal atresia and tracheoesophageal fistula (EA TEF) born to hyperthyroid mothers receiving methimazole (Tapazol) before and during their entire pregnancies. Both mothers were euthyroid during gestation and developed hydramnios diagnosed during weeks 34 and 33 of gestation. Premature delivery (36.2 weeks of gestation) occurred in one case, and both newborn infants were small for date with palpable goiter; one of them had other associated malformations. hypothyroidism was diagnosed by laboratory tests in both cases. Corrective surgery was undertaken, but both newborn infants developed septicemia and renal insufficiency and died in the first week of life. The EA TEF and a normally placed enlarged thyroid gland were confirmed at necropsy. These cases represent a previously unreported example of the association of maternal ingestion of methimazole during pregnancy and EA TEF.- - - - - - - - - - ranking = 6.5943538816277keywords = pregnancy, gestation (Clic here for more details about this article) |
20/78. Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A case report.We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 x 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 microIU/ml) and a low free T4 (0.4 ng/dl). The fetal goiter decreased in size after treatment with four 240-microgram intra-amniotic administrations of levothyroxine. A 2,829-gram male neonate was delivered vaginally at 37 weeks of gestation, showing an euthyroid status at birth. On day 3, free T3 was 6.9 pg/ml and free T4 was 6.4 ng/dl, indicating hyperthyroidism. This persisted for 4 months. His thyroid functions reverted to normal at 4 months of age and have been within normal range since. Undetermined factors might be involved in the development of thyroid dysfunction in the perinatal period.- - - - - - - - - - ranking = 1.0629025877518keywords = gestation (Clic here for more details about this article) |
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