1/11. 1: Infections in pregnant women.Some infections are more serious in pregnant than non-pregnant women because of the potential for vertical transmission to the fetus or infant (eg, varicella, rubella, cytomegalovirus infection, toxoplasmosis and listeriosis). Pre-pregnancy or routine antenatal screening for presence of, or susceptibility to, some of these infections and appropriate management can prevent adverse fetal or perinatal outcomes; screening should include rubella IgG, hepatitis b surface antigen, serological tests for syphilis and hiv antibody. If certain other vertically transmissible infections are suspected because of a positive antenatal test result, confirmatory tests for maternal and, if indicated, fetal infection are essential before intervention is considered (eg, cytomegalovirus infection). For some vertically transmissible infections that are not readily preventable, appropriate management of maternal infection can reduce fetal damage (eg, toxoplasmosis).- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
2/11. Long-term outcome in fetal hydrops from parvovirus B19 infection.parvovirus B19 infection in the fetus is associated with anemia and hydrops and can result in fetal death. Fetal transfusion has been used in an attempt to improve outcome; however, it is associated with its own perinatal morbidity. We report two cases of fetal parvovirus B19 infection that were confirmed by polymerase chain reaction for parvovirus B19 deoxyribonucleic acid in umbilical cord blood. Ultrasonographic signs of compromise were observed at 30 and 24 weeks of gestation. Both fetuses were hydropic and one fetus was also anemic. Serial sonograms demonstrated that the hydrops resolved spontaneously over 3 to 5 weeks after diagnosis. One infant was delivered at 32 weeks of gestation as a result of idiopathic preterm labor. The other infant was delivered at term. Both infants appeared relatively normal at birth and have developed normally in the first year of life. Thus fetal hydrops in association with parvovirus B19 infection does not always lead to poor long-term outcome. A conservative approach without in utero therapy may be appropriate for the management of some of these fetuses.- - - - - - - - - - ranking = 3.2842454392742keywords = gestation (Clic here for more details about this article) |
3/11. Fetal survival after human parvovirus B19 infection: spectrum of intrauterine response in a twin gestation.We report the first known symptomatic survivors of congenital parvovirus infection. One fetus was hydropic and the other was growth retarded. There was no evidence of anemia. The antenatal diagnosis of congenital infection requires a multifaceted approach, which includes serology, cultures, and electron microscopy.- - - - - - - - - - ranking = 6.5684908785485keywords = gestation (Clic here for more details about this article) |
4/11. parvovirus B19 in pregnancy.pregnant women who report possible exposure to a viral illness can present a clinical predicament for obstetric providers. Although some viruses are benign in pregnancy, others can have serious consequences. parvovirus B19, the causative agent of fifth disease, is one of the more serious of the common viruses. Understanding the pathophysiology and appropriate testing for parvovirus will help providers better counsel their patients.- - - - - - - - - - ranking = 5keywords = pregnancy (Clic here for more details about this article) |
5/11. Fetal stroke and congenital parvovirus B19 infection complicated by activated protein c resistance.parvovirus B19 infection in gestation has been associated with severe fetal complications such as anaemia, hydrops and fetal demise. Fetal infection in the first trimester poses the greatest risk for these complications, but infection during the third trimester is more common than previously appreciated and can be associated with severe complications, i.e. fetal death, in the absence of hydrops or classical clinical symptoms. parvovirus B19 infection has been associated with vasculitis and pathological changes in the central nervous system, which may cause stroke. We report a newborn infant with a rare combination of a recent central nervous system infection with parvovirus B19 and a factor v Leiden mutation, who developed fetal stroke. Conclusion: factor v Leiden mutation leads to activated protein c resistance and increases the risk of thromboembolism. thromboembolism occurs rarely in newborns with activated protein c resistance, but can be precipitated by dehydration, asphyxia and infection. Although parvovirus B19 infection of the central nervous system may be a precipitant in neonatal and/or fetal stroke, it can also cause stroke independent of a thrombophilic mutation. In this case, both causative factors may have coincided.- - - - - - - - - - ranking = 1.6421227196371keywords = gestation (Clic here for more details about this article) |
6/11. Severe nonimmune hydrops secondary to parvovirus B-19 infection: Spontaneous reversal in utero and survival of a term infant.We present a case of intrauterine infection with parvovirus B-19 and accompanying severe nonimmune hydrops at 26 weeks' gestation. The fetus showed progressive recovery on ultrasound. A term infant was delivered with hepatosplenomegaly as the only abnormality.- - - - - - - - - - ranking = 1.6421227196371keywords = gestation (Clic here for more details about this article) |
7/11. Fetal-maternal hydrops syndrome in human parvovirus infection.A case of maternal generalized edema with hyponatremia, hypoosmolality and secondary hyperaldosteronism was associated with pseudomolar plasma human chorionic gonadotropin (hCG) concentrations in a case of fetal and placental hydrops due to parvovirus B19 infection. digoxigenin in situ hybridization techniques were effective in demonstrating parvovirus B19 infection on fixed tissues. Hydropic changes in the placenta may have massively increased the maternal plasma hCG concentration with subsequent fluid imbalance leading to maternal hydrops mimicking molar pregnancy.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
8/11. Clinical significance of human parvovirus B19 infection in pregnancy.We present a case of human parvovirus B19 infection in a term pregnancy that resulted in rapid development of hydrops fetalis and death. Clinical aspects of this virus in pregnancy and therapeutic options are discussed.- - - - - - - - - - ranking = 6keywords = pregnancy (Clic here for more details about this article) |
9/11. In utero fetal cardiac resuscitation: a case report.A patient presented at 21 weeks gestation with nonimmune hydrops of her singleton fetus. A cordocentesis confirmed fetal anemia. During the course of the procedure, fetal cardiac arrest occurred. The fetus was resuscitated with intracardiac epinephrine and fetal transfusion was performed. The resuscitation was initially successful, however the fetus died 12 h later.- - - - - - - - - - ranking = 1.6421227196371keywords = gestation (Clic here for more details about this article) |
10/11. parvovirus B19 infection in a twin pregnancy.BACKGROUND: parvovirus infection has been associated with the development of nonimmune hydrops fetalis in pregnancy. This report describes a twin pregnancy in which one fetus was affected by parvovirus B19 and the other was not. CASE: A 35-year-old woman was found to have a twin gestation at genetic amniocentesis. Subsequent ultrasound at 18 weeks showed that twin B had evidence of hydrops fetalis. serum from the mother tested positive for parvovirus B19 immunoglobulin (Ig) G and IgM. Cultured amniotic fluid from twin B was subsequently found to be positive for parvovirus B19. At 20 weeks' gestation, the hydropic fetus died. The unaffected fetus grew normally. At 40 weeks, the unaffected fetus was delivered vaginally with no difficulties. Cord blood from the unaffected fetus was negative for parvovirus B19 IgM. CONCLUSION: This case demonstrates differential infection of parvovirus B19 in a diamniotic, dichorionic twin pregnancy. One twin developed signs of hydrops fetalis consistent with parvovirus B19. The diagnosis was confirmed immunologically and by amniotic fluid culture. The second twin had no evidence of parvovirus B19 and no immunologic suggestion of infection at birth. This is the only known report of such differential transmission of parvovirus B19 in a twin pregnancy.- - - - - - - - - - ranking = 11.284245439274keywords = gestation, pregnancy (Clic here for more details about this article) |
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