1/16. Sudden death in a traveler following halofantrine administration--togo, 2000.On July 17, 2000, a previously healthy 22-year-old U.S. student collapsed and died suddenly while leading a teenage exchange group in West africa. This report summarizes the results of the investigations of this incident, which implicate use of halofantrine for treatment of malaria as the cause of death. Travelers should be warned that halofantrine treatment may be dangerous in persons with cardiac abnormalities or in those taking mefloquine for malaria prophylaxis.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
2/16. Glycyrrhizin and glycyrrhetinic acid determination from formalin-fixed tissue.glycyrrhetinic acid (GA), the main metabolic product of glycyrrhizin (GLY), could be detected in formalin-fixed tissue from a man who died 6 hours after therapeutic administration of a GLY-containing agent. GA was extracted from homogenized formalin-fixed liver tissue and 3 ng GA/g could be detected by HPLC. The extraction from formalin-fixed liver tissue gave the same retention time peak as the GLY control. GA could also be detected by mass spectrometry in the blood sample. This confirms that the man had received a GLY-containing agent for therapeutic use prior to his death and that GA can be determined from formalin-fixed tissue.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
3/16. A case of sudden death after intramuscular injection of butylscopolamine bromide.A 40-year-old man experienced cardiopulmonary arrest after intramuscular injection of 20 mg of butylscopolamine bromide. No pathological changes were found at autopsy, and 1.19 microg/mL of butylscopolamine bromide was detected in his serum. Since he had taken no other drugs, his severe symptoms were thought to have been caused by an anaphylactic reaction to butylscopolamine bromide. Butylscopolamine bromide has been used for many years worldwide, and is considered to be a safe drug, with no reports of severe side effects following intramuscular injection. Since an anaphylactic reaction may not be related to a particular medication, the possibility of such a severe reaction must be considered, even during administration of an ostensibly safe drug such as butylscopolamine bromide.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
4/16. Sudden death due to disease flare with luteinizing hormone-releasing hormone agonist therapy for carcinoma of the prostate.luteinizing hormone-releasing hormone agonist therapy for prostate cancer is a new method of management for metastatic disease. During the initial 1 to 2-week period of administration an increase in serum testosterone concentration can lead to an exacerbation of clinical symptoms (flare phenomenon). Two patients are summarized who received luteinizing hormone-releasing hormone agonist therapy without flare blockade and died suddenly during month 1 of therapy. A review of 765 patients in 9 series found 10.9% who suffered disease flare and 15 who died during disease flare. Of these 17 patients 12 were similar to our 2. These data suggest that any patient placed on luteinizing hormone-releasing hormone agonist therapy for prostate cancer merits some form of flare blockade during the initial 1 or 2 months of therapy.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
5/16. A fatal accident after epidural anesthesia for cesarean section.It is a sobering fact that mishaps during the administration of anesthesia sometimes have a way of initiating problems which escalate step by step to a situation of total disaster for the patient. Inexperience and poor judgment often lie behind such tragedies and the following case report is presented not only as an illustration of this, but also as a useful lesson. The authors only became involved in this case after the anesthesiologist concerned made available his account of the clinical events together with the hospital records. For obvious reasons the anesthesiologist's name has not been given, but he has given his full permission to publish this case. A case report is presented in which a healthy 31-year-old a term para II, requested epidural anesthesia for an elective cesarean section for pelvic disproportion. Repeated attempts to perform epidural anesthesia were necessary. Eventually she developed acute pulmonary edema and resuscitation was not successful. Both mother and fetus died.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
6/16. chlorpromazine accumulation and sudden death in a patient with renal insufficiency.Sudden death has been reported in psychiatric patients before and after the advent of antipsychotic medications. A case of sudden death following chlorpromazine administration in a schizophrenic patient is presented. After receiving a mean daily dose of 780 mg for five days, the patient died suddenly. Laboratory work on day 2 of hospitalization indicated a calculated creatinine clearance of 14 ml/min. The autopsy was noncontributory except for a blood chlorpromazine concentration of 1534 ng/ml. The potential cause of death in this patient and the proposed mechanisms of sudden death in psychiatric patients are discussed. The effect of renal and hepatic disease on chlorpromazine plasma concentrations is presented. This case is the first report of sudden death in a psychiatric patient with a documented elevated antipsychotic plasma concentration. It is also the first report of an elevated chlorpromazine blood concentration in a patient with renal insufficiency.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
7/16. Sudden death following administration of radio contrast media.Six patients died suddenly following the administration of radio contrast media. All had received the so-called older agents which are being replaced by newer contrast agents, which are characterized by reduced osmolality. Five of the six patients experienced almost immediate difficulty in breathing followed by death.- - - - - - - - - - ranking = 1.25keywords = administration (Clic here for more details about this article) |
8/16. Nosocomial pulmonary mucormycosis with fatal massive hemoptysis.We postulate that the previously healthy woman reported here developed abnormal host defense mechanisms because of acute renal failure, metabolic acidosis, hyperglycemia, and glucocorticosteroid administration. pneumonia unresponsive to antibiotics terminated in massive fatal hemoptysis that was due to mucormycosis with rupture of the pulmonary artery into the tracheobronchial tree.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
9/16. cocaine-induced psychosis and sudden death in recreational cocaine users.Fatal cocaine intoxication presenting as an excited delirium is described in seven recreational cocaine users. Symptoms began with the acute onset of an intense paranoia, followed by bizarre and violent behavior necessitating forcible restraint. The symptoms were frequently accompanied by unexpected strength and hyperthermia. Fatal respiratory collapse occurred suddenly and without warning, generally within a few minutes to an hour after the victim was restrained. Five of the seven died while in police custody. blood concentration of cocaine averaged 0.6 mg/L, about ten times lower than that seen in fatal cocaine overdoses. police, rescue personnel, and emergency room physicians should be aware that excited delirium may be the result of a potentially fatal cocaine intoxication; its appearance should prompt immediate transport of the victim to a medical facility. Continuous monitoring, administration of appropriate cocaine antagonists, and respiratory support will hopefully avert a fatal outcome.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
10/16. Sudden death in asthma.Two deaths after sudden severe asthma attacks in young people are reported from a clinic set up to identify and manage "at risk" patients. These deaths occurred despite frequent visits at which recommendations made by previous studies were implemented. The risk factors and management of such episodes have been reviewed. Precautions taken proved inadequate due to the severe, abrupt nature of the attacks, failure of the patients' immediate treatment, and delay in reaching hospital. Consideration should be given to the self-administration of subcutaneous adrenaline or specific beta-agonists, the provision of a detailed medical card, and free access to the nearest hospital in such cases.- - - - - - - - - - ranking = 0.25keywords = administration (Clic here for more details about this article) |
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