1/14. lymphoma-induced polyradiculopathy in AIDS: two cases.Progressive polyradiculopathy is a rare, well-documented complication of the acquired immunodeficiency syndrome in man. It has been commonly attributed to a cytomegalovirus (CMV) infection. We report two HIV-infected patients with clinical and electrophysiological features of a unique, subacute, progressive polyradiculopathy. Post-mortem examination in case 1 disclosed an infiltration of the leptomeninges, the lumbar spinal cord, and the anterior and posterior roots by a B-cell immunoblastic lymphoma. immunochemistry for HIV1 and CMV was negative in the peripheral and the central nervous system. Case 2 showed bone-marrow involvement by a Burkitt type lymphoma. Specific chemotherapy was followed by both clinical improvement of the polyradiculopathy and complete remission on a second bone-marrow biopsy. These findings may indicate that a lymphoma must also be considered a possible cause of polyradiculopathy in AIDS.- - - - - - - - - - ranking = 1keywords = polyradiculopathy (Clic here for more details about this article) |
2/14. Late cytomegalovirus polyradiculopathy following haploidentical CD34 -selected hematopoietic stem cell transplantation.A 55-year-old man with acute myeloid leukemia in second relapse presented 4 months after haploidentical CD34 -selected hematopoietic stem cell transplantation (HSCT) with symmetric, progressive neurological deficits of the lower extremities. Although there was no molecular evidence for drug resistance in the cerebral-spinal fluid, antiviral combination therapy failed to control the rapidly progressing CMV polyradiculopathy (PRP) and encephalitis, which were confirmed by autopsy studies. Late CMV PRP as an unusual manifestation of CMV disease should be kept in mind in patients with suggestive neurological symptoms after HSCT.- - - - - - - - - - ranking = 0.625keywords = polyradiculopathy (Clic here for more details about this article) |
3/14. magnetic resonance imaging of AIDS-related polyradiculopathy.AIDS-related polyradiculopathy is a syndrome associated with cytomegalovirus infection. We report two cases of AIDS-related polyradiculopathy in which spinal T1-weighted MRI with gadolinium-DTPA showed enhancement of the pial lining of the conus medullaris, cauda equina, and lumbar nerve roots. Both patients clinically improved with ganciclovir treatment.- - - - - - - - - - ranking = 0.75keywords = polyradiculopathy (Clic here for more details about this article) |
4/14. Rapid diagnosis of cytomegalovirus in the cerebrospinal fluid of a patient with AIDS-associated polyradiculopathy.polyradiculopathy is an uncommon but serious neurologic disorder that can complicate the course of the acquired immunodeficiency syndrome. We report a case in which the presence of cytomegalovirus was detected in cerebrospinal fluid by immunoperoxidase staining. In addition, large atypical cells with flocculogranular cytoplasmic inclusions were present. These cells were found to be positive for cytomegalovirus by immunoperoxidase staining. Rapid diagnosis by this method permitted early intervention with ganciclovir.- - - - - - - - - - ranking = 0.5keywords = polyradiculopathy (Clic here for more details about this article) |
5/14. ganciclovir in the treatment of progressive AIDS-related polyradiculopathy.We present 7 HIV-infected patients with a unique, subacute, progressive polyradiculopathy. All had AIDS, sacral sensory loss, acute urinary retention, and progression to flaccid paraparesis in days to weeks. cytomegalovirus was cultured from spinal fluid of 4 patients, and postmortem examination of the 1st 5 patients disclosed an inflammatory polyradiculopathy with cytomegalic inclusions. The inclusion-bearing cells were immunocytochemically positive for cytomegalovirus. Two patients who received early anti-cytomegalovirus treatment with ganciclovir improved. Thus, early recognition and treatment with ganciclovir may be effective in this otherwise fatal condition.- - - - - - - - - - ranking = 0.75keywords = polyradiculopathy (Clic here for more details about this article) |
6/14. guillain-barre syndrome with cytomegalovirus infection of peripheral nerves.cytomegalovirus (CMV) infection involving multiple organ systems is a common finding in the acquired immunodeficiency syndrome. Acute CMV neuritis was a complication in two patients with acquired immunodeficiency syndrome. The diagnosis was made in both patients at autopsy, where typical CMV inclusions in the lumbar dorsal roots were noted in one patient and the same inclusions were found in the retroperitoneal peripheral nerves in a second patient. Electron microscopy confirmed the presence of viral particles in affected nerve segments. Patient 1 was hospitalized for ascending motor paralysis that remained unexplained at the time of death. In patient 2 the finding of CMV neuritis was incidental. Although CMV infection has been cited as an event antecedent to acute inflammatory polyradiculopathy (guillain-barre syndrome), to our knowledge morphologic evidence of the presence of virus has not been documented in this disease previously.- - - - - - - - - - ranking = 0.125keywords = polyradiculopathy (Clic here for more details about this article) |
7/14. Progressive polyradiculopathy in acquired immune deficiency syndrome.We studied three patients with acquired immune deficiency syndrome (AIDS) and progressive polyradiculopathy. Postmortem examination of one patient disclosed extensive necrosis, inflammatory infiltrates, and focal vasculitis of spinal roots. Typical cytomegaloviral (CMV), intranuclear, and intracytoplasmic inclusions were noted within enlarged endoneurial and endothelial cells. Progressive polyradiculopathy is an unusual complication of AIDS; CMV may be the causative agent in certain cases.- - - - - - - - - - ranking = 0.75keywords = polyradiculopathy (Clic here for more details about this article) |
8/14. spinal cord syndromes in the acquired immune deficiency syndrome.Two patients with AIDS developed paraparesis. Neuropathological post mortem examination in one revealed cytomegalovirus polyradiculopathy, and in the second, vacuolar myelopathy which occurred in association with brain lesions resembling Marchiafava-Bignami Syndrome.- - - - - - - - - - ranking = 0.125keywords = polyradiculopathy (Clic here for more details about this article) |
9/14. cytomegalovirus polyradiculoneuropathy in acquired immune deficiency syndrome.A 34-year-old homosexual man with acquired immune deficiency syndrome developed extraocular muscle deficits, chorioretinitis, and paraplegia without sensory symptoms. EMG showed severe diffuse denervation, but only mildly slowed nerve conduction velocities, in both legs. meningitis persisted for 6 weeks and was exacerbated prior to the patient's death. Necropsy revealed subpial and subependymal cytomegalovirus (CMV) infection. histology of ventral roots demonstrated proximal CMV infection and massive fiber loss. In this immunosuppressed patient, CMV caused a severe motor polyradiculopathy by selective destruction of the motor neurons of ventral spinal roots and motor cranial nerves.- - - - - - - - - - ranking = 0.125keywords = polyradiculopathy (Clic here for more details about this article) |
10/14. cytomegalovirus polyradiculopathy caused by a ganciclovir-resistant strain.polyradiculopathy caused by cytomegalovirus (CMV) is a rare but serious neurological disorder that occurs late in the course of hiv-1 infection and is potentially treatable with antimicrobial agents active against CMV. We describe a patient with CMV infection caused by a strain that was resistant to ganciclovir. This case demonstrates one potential mechanism of therapeutic failure and illustrates the potential pathogenicity of strains that are resistant to antiviral drugs.- - - - - - - - - - ranking = 0.5keywords = polyradiculopathy (Clic here for more details about this article) |
| | Next -> |