1/51. Micropapillary variant of transitional cell carcinoma of the ureter.Micropapillary variant of transitional cell carcinoma (TCC) is a rare entity, having a distinct micropapillary component mimicking papillary serous carcinoma of the ovary and has been reported exclusively in the urinary bladder. We experienced a case of micropapillary variant of TCC in the ureter. The tumor showed a predominant proportion of micropapillary component and accompanied a TCC in situ lesion and a high-grade TCC. A metastatic lesion in the regional lymph node also showed an entirely micropapillary pattern. Initially, our case was confused with adenocarcinoma, especially metastatic, because the micropapillary architecture resembled an abortive glandular structure and tumor cell nests were predominantly located in empty spaces mimicking vascular invasion. The patient died with peritoneal metastases 20 months after the initial diagnosis. We report the first case of a micropapillary variant of TCC occurring in the ureter.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/51. Benign ectopic prostatic glands in subvesical skeletal muscle. A lesion resembling carcinoma.In physiological instances, the prostatic acini may be intermingled with striated muscle fibers in the apex and in the anterolateral subcapsular areas of the prostate. We report an unusual lesion composed of benign prostatic glands, which were scattered between skeletal muscle fibers beneath the bladder submucosa. A 55-year-old man underwent four transurethral resections and radiation therapy for a urothelial carcinoma of the urinary bladder. Subsequently a cystectomy was performed. In the resection specimen, the prostate specific antigen-positive glands were found among the skeletal muscle bundles close to the bladder submucosa. They were seen as small groups of haphazardly scattered or isolated glands mimicking an infiltrative pattern of a prostatic adenocarcinoma. Prominent nucleoli in some glands further contributed to the worrisome appearance of the lesion. However, the high molecular weight cytokeratin 34 beta E12 exhibited basal cell layers of the glands, and the subsequent course of disease confirmed the benign nature of the lesion. The juxtaposition of the prostatic acini with the skeletal muscle out of the apex and the anterolateral subcapsular areas of the prostate should be included in the differential diagnosis of prostatic carcinoma in urinary bladder and prostate biopsies.- - - - - - - - - - ranking = 9keywords = gland (Clic here for more details about this article) |
3/51. muir-torre syndrome.muir-torre syndrome is a rare autosomal dominant condition in which multiple primary malignancies occur together with a sebaceous gland tumour. Early recognition of the syndrome in patients with sebaceous gland tumours should facilitate early detection of subsequent malignancies if the patient with entered into appropriate screening programmes. A case occurring in scotland is described and implications for management, screening for members of the family are discussed.- - - - - - - - - - ranking = 2keywords = gland (Clic here for more details about this article) |
4/51. Concurrent tubulovillous adenoma and transitional cell carcinoma associated with diffuse gastric and intestinal metaplasia of the defunctioned ureter.Villous adenoma is a common lesion of the gastrointestinal tract, but it is rare in the ureter. Thus, as far as we know, only one case limited to this location has been described. Intestinal metaplasia of the urothelium is not rare. However, only one case of gastric metaplasia with pseudopyloric glands has been described in the literature. We here report in detail on a tubulovillous adenoma of the ureter associated with diffuse gastric and intestinal metaplasia and a concurrent primary, solid, high grade transitional cell carcinoma, with extensive clear cell change, in a 56-year-old male patient. He had undergone a left nephrectomy for renal tuberculosis twenty years earlier, and the lesions developed in the ureteric stump. To the best of our knowledge, such a combination of lesions has not been reported previously either in the ureter or in the rest of the urinary tract. The coexistence of diverse lesions in our case might represent the pluripotentiality of the urothelium in association with chronic inflammation and neoplastic induction. The present report also emphasizes the metaplastic and malignant potential of a defunctioned urothelial structure. This case is of particular interest, because these coexistent lesions arose simultaneously with an anatomically separate adenocarcinoma of the rectum (Dukes' B). The patient died 76 days after admission. The dismal prognosis of our case was determined by the advanced anatomical stage and the histological high grade of the transitional cell carcinoma of the ureter.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/51. Esophageal basaloid carcinoma with marked myoepithelial differentiation.A case of esophageal basaloid carcinoma with marked myoepithelial differentiation in a 60-year-old man is reported. The tumor arose as an exophytic mass, measuring 65 x 60 mm, in the middle thoracic esophagus. Approximately two-thirds of the tumor surface was covered with non-cancerous esophageal epithelium. The depth of tumor invasion was limited to the submucosal layer. Histologically, about 70% of the tumor contained a typical basaloid carcinoma component and about 30% contained glandular and intercalated duct-like components with distinct epithelial and myoepithelial differentiation. The tumor presented no component of distinct squamous cell carcinoma, but a small portion of cribriform-like structure, which is typical of adenoid cystic carcinoma, was visible. The inner epithelium composing the intercalated duct-like structure showed immunohistochemical positivity for cytokeratin 14, and the outer epithelium lining adjacent to the stroma showed positivity for alpha-smooth muscle actin. These findings supported epithelial/myoepithelial differentiation. To our knowledge, our case is the first patient with an esophageal basaloid carcinoma showing marked myoepithelial differentiation.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
6/51. Urethral meatal carcinoma following cystourethrectomy for bladder carcinoma.The multicentric potential of urothelial malignancy is well recognized, and the occurrence of urethral neoplasm after cystectomy is attributed to this characteristic of urothelial tumors. Eight instances of tumors in the glandular urethral remnant after subtotal urethrectomy illustrate the necessity of excising the fossa navicularis and urethral meatus when performing urethrectomy.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
7/51. Human papillomavirus type 16 found in primary transitional cell carcinoma of the Bartholin's gland and in a lymph node metastasis.We report a case of primary transitional cell carcinoma of the Bartholin's gland and its lymph node metastasis that contained HPV 16 sequences by polymerase chain reaction. The physical state of HPV 16 dna in the primary cancer was investigated by Southern blot analysis which showed the presence of the episomal form of viral dna. Our findings of HPV 16 dna in the transitional cell carcinoma of the Bartholin's gland and its metastasis would indicate that both tumors arose from a single clonal event, thus providing evidence that the HPV 16 may have an oncogenic potential in this rare malignancy even in the episomal state.- - - - - - - - - - ranking = 6keywords = gland (Clic here for more details about this article) |
8/51. Large cerebellar lesion as original manifestation of transitional cell carcinoma of the bladder.patients with transitional cell carcinoma of the bladder classically present with irritative voiding symptoms or painless hematuria. Common sites of vascular metastases include the liver (38%), lung (36%), bone (27%), adrenal glands (21%), and intestine (13%). Vascular metastasis to the brain, without a prior history of chemotherapy, is extremely rare. To our knowledge, this is the first report of a patient with bladder transitional cell carcinoma whose original presentation was from a symptomatic, metastatic, cerebellar lesion.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
9/51. Case report: Incidental primary transitional cell carcinoma of the prostate treated with transurethral prostatectomy only.A 65-year-old man presented with a history of painless gross hematuria and severe obstructive symptoms. Abdominal ultrasonography and intravenous urogram revealed the absence of any disease in the urinary tract except benign prostatic hyperplasia. He underwent a transurethral resection of the prostate and was found to have incidental primary transitional cell carcinoma of the prostatic ducts localized to the gland. Radical cystoprostatectomy was offered but the patient was hypertensive, had a history of cerebrovascular accident and refused another major operation. Since also his general condition was not good enough for further therapy, he was treated with transurethral prostatectomy only. After 16 months he is still alive and free of disease.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
10/51. Basaloid carcinoma of the prostate gland. An unusual finding.OBJECTIVES: Carcinoma with basaloid features, known as basaloid carcinoma of prostate, is an extremely rare tumor. We report the clinical, histological and immunohistochemical findings in a case of prostatic basaloid carcinoma. methods/RESULTS: A 68-year old man consulted with a two-year history of increasing urinary outflow obstruction that developed into acute urinary retention. A routine suprapubic prostatectomy was carried out, following which normal voiding was achieved. Microscopically, the neoplasm showed different histological aspects; some areas were typical of basal cell hyperplasia, intermixed with other in which there was evidence of basaloid carcinoma. Immunohistochemical staining of the basaloid carcinoma revealed cytokeratin 34betaE12 immunoreactivity without expression of prostatic specific antigen and prostatic acid phosphatase. CONCLUSION: This case is a very unusual basaloid carcinoma and may indicate that there is a spectrum in prostate basal cell proliferation.- - - - - - - - - - ranking = 4keywords = gland (Clic here for more details about this article) |
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