1/7. Premature labor and leukoerythroblastosis in a newborn with parvovirus B19 infection.Leukoerythroblastosis is a rarely observed disease characterized by the presence of leukocytosis, erythroid and myeloid blast cells in peripheral blood. To our knowledge, it had not been diagnosed in a premature newborn before the case we report have.A female baby weighing 1164 grams, who was born prematurely at the 29th week of gestation by cesarean section was referred to our newborn intensive care unit due to prematurity and respiratory distress with no prenatal pathological findings. physical examination revealed tachypnea and hepatosplenomegaly. Routine laboratory measurements showed significant leukocytosis (85,000/mm3) and anemia (Hb: 9.6 g/dL and Hct: 27.6%). The platelet count was normal. The peripheral blood smear suggested leukoerythroblastosis with the presence of nucleated erythrocytes, monocytosis, and 4% blasts. bone marrow cytogenetic examination was normal. parvovirus B19 Ig G and M serology were detected to be positive.The etiological factors observed in leukoerythroblastosis occurring during neonatal and early childhood period are congenital-postnatal viral infections, juvenile myelomonocytic leukemia and osteopetrosis. To our knowledge, no case of leukoerythroblastosis in such an early phase has been reported in the in literature. As a result, premature delivery and leukoerythroblastosis were thought to have developed secondary to intrauterine parvovirus B19 infection.Leukoerythroblastosis is a rarely observed disease characterized by the presence of leukocytosis, erythroid and myeloid blast cells in peripheral blood. It is reported that it can be observed following hematologic malignancies especially juvenile myelomonocytic leukemia, acute infections, hemolytic anemia, osteopetrosis, myelofibrosis, neuroblastoma and taking certain medicines. To our knowledge, it has not been diagnosed in a premature newborn before. Here we the case of a newborn who was referred to our intensive care unit due to being born prematurely at the 29th week of gestation and diagnosed with leukoerythroblastosis.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |
2/7. An unusual case of pycnodysostosis.A 6 year old boy with clinical and radiological features of pycnodysostosis is described. In addition to pycnodysostosis he had a myelophthisic type of anaemia suggesting an overlap with osteopetrosis.- - - - - - - - - - ranking = 10.807235287694keywords = anaemia (Clic here for more details about this article) |
3/7. Metastatic oligodendroglioma presenting as a leukoerythroblastic anaemia.The clinical course of a patient with oligodendroglioma, treated initially with surgery and radiotherapy, is described. The patient later presented with leukoerythroblastic anaemia due to metastasis to bone marrow. This behaviour had not been previously described in oligodendroglioma.- - - - - - - - - - ranking = 54.036176438468keywords = anaemia (Clic here for more details about this article) |
4/7. Coeliac disease presenting with a leuco-erythroblastic anaemia.A 49-year-old Irishman presented as an emergency with watery diarrhoea and a leuco-erythroblastic anaemia. Investigations showed that he had coeliac disease but no evidence of bone marrow infiltration. His leuco-erythroblastic picture disappeared on treatment with iron and folic acid.- - - - - - - - - - ranking = 54.036176438468keywords = anaemia (Clic here for more details about this article) |
5/7. Microangiopathic hemolytic anemia as an initial presentation of metastatic cancer of unknown primary origin.Microangiopathic hemolytic anemia (MAHA) is a well-documented but rare complication of disseminated cancer; it usually occurs in the late or terminal stage of cancer. We describe a case of metastatic carcinoma of unknown origin in which MAHA was the initial presentation. A 36-year-old woman came to our hospital with lower back pain and progressive exertional dyspnea for 8 weeks. Hemolytic anemia, thrombocytopenia, and leukoerythroblastosis were found on admission. The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. bone marrow biopsy disclosed metastatic carcinoma. After careful workup, we failed to find the primary site of cancer. The anemia and thrombocytopenia responded dramatically to combination chemotherapy with 5-fluorouracil, mitomycin C, and cisplatin. This case indicates that metastatic carcinoma should be included in the differential diagnosis in previously healthy patients with MAHA.- - - - - - - - - - ranking = 5keywords = hemolytic (Clic here for more details about this article) |
6/7. bone marrow involvement and obstructive jaundice in farber lipogranulomatosis: clinical and autopsy report of a new case.We report a case of farber lipogranulomatosis in a girl with hepatosplenomegaly, macular cherry-red spot, and subcutaneous nodules who developed liver dysfunction with jaundice and ascites, and myelophthisic anaemia because of infiltration of bone marrow with storage cells. acid ceramidase assay confirmed the diagnosis. We conclude that the bone marrow dysfunction and cherry-red spot are features of type IV farber lipogranulomatosis that have not been previously recognized, and should be added to the clinical phenotypic description.- - - - - - - - - - ranking = 10.807235287694keywords = anaemia (Clic here for more details about this article) |
7/7. Neurological complications of osteopetrosis.The clinical course of twins with osteopetrosis has provided a catalogue of the neurological complications that may occur with the disorder. Such a list has not previously been compiled: (1) hydrocephalus - probably due to outflow obstruction in the posterior fossa. (2) sagittal sinus thrombosis - due to bony encroachment, or to hematological causes. (3) exophthalmos - due to bony encroachment in the orbit. (4) Foraminal occlusion at the base of the skull, producing compromise of cranial nerves and vessels. (5) paraparesis - cause unknown, perhaps due to spinal stenosis. (6) anemia - myelophthisic, although a hemolytic component due to hypersplenism has been identified, as well.- - - - - - - - - - ranking = 1keywords = hemolytic (Clic here for more details about this article) |