1/9. Intranuclear tubular structures observed in the cells of an alveolar cell carcinoma of the lung.Intranuclear tubular structures observed in the cells of an alveolar cell carcinoma of the lung are described. The structures were composed of membraneous tubules, measured about 60 nm in diameter, and had an electron-dense central core. These unusual structures were seen in the nuclei of neoplastic cells (Type II pneumocytes). The nature of the tubular structures remains unsolved, but morphologic characteristics and associated grnaulomatous reaction in the stroma imply the possibility of an unknown virus-like infection.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/9. Alveolar cell carcinoma on CT scanning. The value of the air bronchogram sign.The computed tomography findings in alveolar disease are described in a patient with alveolar cell carcinoma. The recognition of an air bronchogram on CT scanning may be useful in establishing the alveolar nature of diffuse or focal lung disease.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/9. Bronchiolo-alveolar carcinoma with nodal metastases. An ultrastructural study.A case of bronchiolo-alveolar carcinoma of the lung was studied by light and electron microscopy. Type II granular pneumocytes were seen in the lymph node metastases of the tumor, a finding not reported previously. We feel that the presence of these cells in metastatic foci indicates their neoplastic nature, and provides evidence that bronchiolo-alveolar carcinoma arises from type II cells.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/9. lung metastasis of malignant epithelioid hemangioendothelioma mimicking a primary intravascular bronchioalveolar tumor. A histologic, ultrastructural, and immunohistochemical study.A 40-year-old woman presented with multiple nodules in both lungs and a small tumoral mass at the level of the left brachial artery. A pathologic diagnosis of pulmonary intravascular bronchioloalveolar tumor (IVBAT) and epithelioid hemangioendothelioma of the limb was established. Morphologic and immunohistochemical studies highly suggest that both tumors are manifestations of the same neoplastic process. In this case a metastatic nature of the IVBAT is suggested. The diagnosis of pulmonary IVBAT should be followed by a search for sclerosing vascular tumors elsewhere. Finally, the results substantiate the vascular origin of the IVBAT.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/9. Aggressive nature of a "cold" lesion depicted by positive flow and blood pool phases of a bone scan.One of the explanations of a cold lesion on static bone imaging is the presence of an aggressive, destructive lesion. This is the first reported case of such a lesion with an aggressive nature that was confirmed by abnormal flow and pool images.- - - - - - - - - - ranking = 5keywords = nature (Clic here for more details about this article) |
6/9. Angiogenic nature of the "intravascular bronchioloalveolar tumor" of the lung: an electron microscopic study.An intravascular bronchioloalveolar tumor of lung (IVBAT) was studied with electron microscopy. Based on ultrastructural evidence and information obtained from the literature, we propose the following: (1) IVBAT is a true pulmonary neoplasm with distinctive morphologic features; (2) it consists of cells with endothelial characteristics and is probably derived from multipotential mesenchymal reserve cells; (3) it is not related to the typical bronchioloalveolar tumor of lung; (4) a more appropriate designation for this unusual pulmonary neoplasm is "sclerosing angiogenic tumor."- - - - - - - - - - ranking = 4keywords = nature (Clic here for more details about this article) |
7/9. Cell incohesiveness and pattern of extension in a rare case of bronchioloalveolar carcinoma.A unique case of adenocarcinoma of the lung that showed aerogenous extension is presented. Although the primary focus was the usual invasive bronchioloalveolar carcinoma, the tumor cells were dissociated, floating and filling the alveolar spaces, the bronchioli, and the small bronchi at the periphery of the primary tumor and in every involved area in other lobes of the lung. Massive tumor cells were expectorated in coincidence with the appearance of abnormal densities on chest X-ray films. Ultrastructurally the dissociated tumor cells had numerous microvilli on the cell surface and rarely showed intercellular junctions. The tumor cells also contained well-developed rough and smooth endoplasmic membranes, crista-vesicular-type mitochondria, electron-dense granules, and granules with myelinlike figures. No mucous granules and no Clara-cell-type secretory granules nor lamellar bodies of the type seen in normal granular pneumocytes were seen. From these findings, it was concluded that the tumor cells in this case were rather poorly differentiated but somewhat resembled the hyperplastic cuboidal alveolar cells seen in the damaged lung and that they proliferated freely in airways, presenting aerogenous metastases. The biologic behavior of this tumor might be partly explained by the incohesive nature of the tumor cells.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
8/9. Bronchiolo-alveolar carcinoma in angio-immunoblastic lymphadenopathy.A 78-year-old woman presented progressive weakness of three months' duration and generalized lymphadenopathy. Lymph-node biopsy histopathology was diagnosed as immunoblastic lymphadenopathy. As the patient's condition was deteriorating rapidly, she was given corticosteroid with clinical improvement. Initially no distinct radiographic abnormalities of the lungs were seen however, a subsequent solitary nodule in the left lung base was detected. histology showed a bronchiolo-alveolar carcinoma. Pulmonary parenchymal involvement in angioimmunoblastic lymphadenopathy (A.I.L.) has been previously well documented and radiographic abnormalities usually consist of well-circumscribed parenchymal infiltrates. The possibility of a development of bronchiolo-alveolar carcinoma in A.I.L. may be the consequence of a deficiency of the cellular immunity aggravated in part by an immunosuppressive treatment. The hypothesis of the paraneoplastic nature of A.I.L. has also been raised. There are, therefore, always compulsory reasons to check the nature of the pulmonary involvement.- - - - - - - - - - ranking = 2keywords = nature (Clic here for more details about this article) |
9/9. Duct ectasia due to mucus-producing cancers with intraductal extension: histopathologic correlation with radiologic imagings.BACKGROUND: Although duct ectasia due to mucus-producing pancreatic cancer has been well known, its occurrence in other organs has not been reported. We have studied the pathologic basis of the radiologic features in cases of mucus-producing cancer with intraductal extension. methods: We conducted a comparative study of detailed various radiographic images and pathological findings in 10 cases of mucus-producing cancers (four of mucus-producing pancreatic cancer, two of mucinous gastric cancer with diffuse lymphangitic liver metastasis, and four cases of bronchoalveolar cell carcinoma with cyst or cavity). RESULTS: When mucus-producing cancer occurs in a secretory duct or extends into lymphatic ducts, the normal duct is dilated due to the mucus and increased internal pressure, leading to the formation of a cyst and cavity. Because of having the liquid property of mucus floating cancer cells, the lesion can easily progress to continuous ducts as well as regionally. CONCLUSIONS: In cases of mucus-producing cancer with extension into the ductal structure not only in the pancreas but also in the lung and liver, continuous duct ectasis and cysts filled with mucus or cavities of all sizes made by the nature of the mucus may be detected by CT and US.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |