1/14. Punctate keratoderma-like lesions on the palms and soles in a patient with chloracne: a new clinical manifestation of dioxin intoxication?We report what we believe to be a novel skin manifestation of dioxin intoxication. A 30-year-old woman with 2,3,7, 8-tetrachlorodibenzo-p-dioxin levels of 144,000 pg g-1 blood fat presented with severe chloracne that affected the entire integument. She also exhibited acral granuloma annulare-like lesions and distal onycholysis and, at a later time point, showed signs of hypertrichosis, as well as brownish-grey hyperpigmentation of the face. In addition, she developed punctate keratoderma-like lesions on the palms and soles. These lesions were negative for human papillomavirus and histologically characterized by cone-shaped hyperkeratoses invaginating, but not penetrating, into the dermis. Squamous syringometaplasia of the eccrine glands was observed in the immediate vicinity of these lesions. Both clinically and histologically these alterations are essentially indistinguishable from what is described as keratosis punctata palmaris et plantaris (KPPP). Although a fortuitous coincidence of chloracne and KPPP cannot be formally excluded, the possibility exists that in our patient toxic levels of dioxin were causally involved in this disorder of keratinization.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/14. Pronounced and early acne in Apert's syndrome: a case successfully treated with oral isotretinoin.An unusual case of widespread acne unresponsive to treatment with early onset in a child with Apert's syndrome is presented. The patient eventually responded to oral isotretinoin therapy. The morphological profile of the sebaceous glands and the expression of proliferative markers and androgen receptors were evaluated in seboblasts and sebocytes using morphological, ultrastructural and immunohistochemical techniques. There were no significant differences in staining for proliferative markers and nuclear expression of androgen receptors in the glands from the patient and four healthy controls. Our results support the view that acne in Apert's syndrome is not sustained by abnormalities of the sebaceous glands demonstrable with conventional morphological techniques, and that it does not depend on an increased expression of androgen receptors.- - - - - - - - - - ranking = 3keywords = gland (Clic here for more details about this article) |
3/14. Actinic superficial folliculitis.Actinic superficial folliculitis was first described in 1985, and since then only three reports have been published. Clinically and histopathologically this disease is very particular and has been suggested to be considered as an entity. We report on a 30-year-old man who presented with an extensive superficial follicular pustulosis on his back, shoulders and upper chest after exposure to intense heat and subsequent sweating on a sunny day. The pustules arose within 24-36 h afterwards. histology and immunohistochemistry revealed subcorneal pustules, suppurative folliculitis and an infiltrate consisting of T cells, macrophages and neutrophils around the hair follicle, sebaceous glands and small vessels. To the best of our knowledge this is the fourth report on actinic superficial folliculitis and the first on which a characterization of the inflammatory infiltrate has been performed. Because of the impressive, unique symptoms and the characteristic histology we agree with those who have suggested that actinic superficial folliculitis is a new entity.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
4/14. A case of Langerhans histiocytosis with hiv-like immunodeficiency.A case of histiocytosis X (Langerhans type) associated with bullous pulmonary emphysema and acquired immune deficiency, regarding CD4 positive cells, is described. Previous history was remarkable for skin lesions which first appeared in 1981 and progressively worsened, diabetes insipidus diagnosed in 1986, and bullous pulmonary emphysema detected in 1988. biopsy results of skin lesions were consistent with histiocytosis X. thyroid gland involvement was found by means of cytological examination. The search for hiv infection (also performed by means of immunoblotting and PCR) was negative. To our knowledge the immunodeficiency detected in histiocytosis X affects the T suppressor lymphocyte subset, so we thought this peculiar case was worth describing.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/14. An acne-free naevus.Investigation of rare disorders may sometimes help in the understanding of common problems. We describe a patient with an unusual and previously unreported acne-free naevus occurring in an area severely affected by acne. Investigation revealed smaller sebaceous glands, a reduced sebum excretion rate, decreased number of corynebacterium acnes in the pilosebaceous ducts and a reduced conversion of testosterone to 5 alphadihydrotestosterone in the areas which were free of acne compared with acne-bearing skin. The results of these investigations support some of the suggested mechanisms responsible for the development of acne.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
6/14. Irradiation-induced polyglandular neoplasia of the head and neck.Eighteen patients are presented with twenty-one tumors of the head and neck, which include ten salivary gland tumors and eight parathyroid adenomas. Eight of the patients also had thyroid neoplasms. All patients had a history of prior irradiation to the head and neck. Seventy per cent of the salivary gland tumors and 37 per cent of the thyroid tumors were malignant. Recommendations are made for detection and treatment.- - - - - - - - - - ranking = 6keywords = gland (Clic here for more details about this article) |
7/14. bulimia nervosa and acne may be related: a case report.Acne is a very common, often cosmetically disfiguring, cutaneous condition of adolescence that is associated with increased sebaceous gland activity. We present the case of a patient with bulimia who reported that the negative effect of acne on her appearance increased her body image concerns and exacerbated her eating disorder. Improvement of the acne was associated with a significant improvement in her eating disorder. Eating disordered patients may go on restrictive diets in order to control their acne since levels of androgens, which are one of the primary stimulants of sebaceous gland activity, are lower in starvation. As a significant number of adolescents with eating disorders also develop acne, it is important for the clinician to be aware of this previously unreported association between acne and eating disorders, and to evaluate the impact of acne upon the patient's body image and eating behaviour.- - - - - - - - - - ranking = 2keywords = gland (Clic here for more details about this article) |
8/14. Syringocystadenoma papilliferum developed from giant comedo: a case report.A case of syringocystadenoma papilliferum in a 44-year-old Japanese male provided interesting clinical and histological findings. The lesion was diagnosed clinically as an infectious when on the flexor aspect of the right thigh. Optical microscopical examination of serial sections showed that the tumor parenchyma was deeply seated along the boundary zone between the cutis and subcutis around the lower half of a giant comedo, and extended into the surrounding tissues from the non-keratinized epithelial portion of the giant comedo where the non-keratinized epithelium merged with the upper, keratinized epithelium. The tumor thus appeared to have developed from the non-keratinized transitional epithelium corresponding to the intrafollicular part of the apocrine sweat gland apparatus. Although 103 cases of syringocystadenoma papilliferum have been reported from japan since 1924, the present findings are both clinically and histologically unique.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
9/14. A case of partial sirenomelia and possible vitamin a teratogenesis.Prenatal echographical findings of a partial sirenomelic fetus are described. An attempt was made to terminate pregnancy by administration of prostaglandin F2 alpha, but uterine rupture occurred. The teratogenic role of vitamin a ingested by the mother in the periconceptional period is discussed.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
10/14. skin pigmentation secondary to minocycline therapy.Localized brown to blue-black discoloration of the skin occurred in three patients receiving long-term minocycline hydrochloride therapy. Abundant perivascular pigmented material was present at all levels of the dermis below the upper papillary portion. Histochemical studies demonstrated reactivity with the Prussian blue stain and the Fontana-Masson silver technique. The granules were brightly refractile by dark-field illumination. Ultrastructurally, there were membrane-bound dense intracellular inclusions differing from melanin and iron but identical to those known to occur in the thyroid glands of minocycline-primed laboratory animals. The abnormal pigment most likely represents a metabolic derivative of minocycline.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
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