1/18. Myxoid liposarcoma with transition to round-cell lesion-cell cycle regulator genes and telomerase activity characterizing tumor progression: a case report.A mixed myxoid/round cell liposarcoma was macrodissected in its 2 histologic components and investigated for genetic differences between its low-grade myxoid and the high-grade round-cell region. For both, we failed to detect p53 gene mutations, loss of heterozygosity at the p53 or Rb genes, and p53 protein expression. The round-cell component showed a high telomerase activity, and an elevated c-myc mRNA and protein expression. The myxoid component was characterized by a lack of telomerase activity and low c-myc mRNA expression, and immunohistochemistry failed to detect the c-myc protein. There was a higher Mib-1 proliferation index in the round-cell portion. The same specific translocation t(12;16) and the fusion transcript type II in both components confirmed the close relationship between myxoid and round-cell liposarcomas. telomerase activity and increased c-myc expression seem to be helpful molecular markers for characterizing tumor progression in myxoid liposarcoma.- - - - - - - - - - ranking = 1keywords = cycle (Clic here for more details about this article) |
2/18. Signet-ring cell carcinoma of unknown primary location. Metastatic to lower back musculature - remission following FU/FA chemotherapy.The detection of gastrointestinal signet-ring cell carcinoma by endoscopy can be a diagnostic challenge. The main clinical features include atypical metastasis and a poor prognosis.We present a case of a metastasizing signet-ring cell carcinoma with unknown primary location arising in 71-year-old female. Following 6 cycles of a routine intravenous FU/FA chemotherapy, an almost complete remission could be observed. After 2 years of follow up, metastatic recurrence was detected to the lower back musculature. This case report emphasizes the difficulties in diagnosing signet-ring cell carcinoma by endoscopy and demonstrates an unusual clinical course.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
3/18. A case of secondary myocardial lymphoma presenting with ventricular tachycardia.Malignant lymphoma can involve the cardiac cavity or myocardium as a mass. Clinical symptoms of its cardiac involvement are usually absent or nonspecific, making the diagnosis of the cardiac involvement very difficult before death. We experienced a patient with secondary myocardial non-Hodgkin's lymphoma presenting with sustained ventricular tachycardia (VT) as a primary clinical problem. A 39-yr-old woman visited our hospital because of dyspnea and palpitation for 7 days. physical examination revealed rapid heart beat with variable intensity of the first heart sound and soft mass in the lower abdomen. VT with a cycle length of 480 msec was recorded in resting 12-lead electrocardiogram. Two well-circumscribed hypo-echogenic round masses were demonstrated in the interventricular septum and left ventricular posterior wall. Cytological examination of aspirated pericardial fluid and percutaneous needle biopsy of the abdominal mass revealed a diffuse large cell type non-Hodgkin's lymphoma. Myocardial masses and ventricular tachycardia resolved with chemotherapy using cyclophosphamide, adriamycin, vincristine and prednisone regimen. To our best knowledge, the same case as ours has not been reported previously.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
4/18. Intranodal palisaded myofibroblastoma with overexpression of cyclin d1.Intranodal palisaded myofibroblastoma (IPM) is a rare benign spindle-cell tumor of lymph nodes with myofibroblastic/smooth muscle differentiation. We present another case of IPM that confirms the myofibroblastic differentiation of the tumor cells and identifies the so-called amianthoid fibers as collagen deposits by immunohistochemical and ultrastructural techniques. Because IPM shares histomorphologic characteristics with an inflammatory myofibroblastic tumor that has been associated with a virus-induced alteration of cell cycle regulation, the diagnostic approach was extended in this case. We were able to demonstrate cyclin d1 overexpression but could detect neither amplification of the CCND1 gene nor allelic loss at chromosomes 9p22-21 and 13q (surrounding the genes p16 and Rb, respectively). Furthermore, no evidence of human herpesvirus-8 or Epstein-Barr virus infection could be found by polymerase chain reaction or immunostaining. Nevertheless, our results point to the cell cycle regulatory genes as a factor in the pathogenesis of IPM.- - - - - - - - - - ranking = 0.5keywords = cycle (Clic here for more details about this article) |
5/18. serum lactic dehydrogenase as a tumor marker in dysgerminoma.dysgerminoma is the most common malignant germ cell tumor in young women. The management of advanced-stage dysgerminoma challenges the gynecologic oncologist to achieve maximal survival, while maintaining childbearing potential. radiation therapy has been extremely successful in curing dysgerminoma, but ovarian conservation is usually not possible. In contrast, various chemotherapeutic regimens have achieved high cure rates with continued ovarian function. Diagnosing recurrent dysgerminoma promptly so that salvage therapy can be initiated is important when conservative management has been employed. While alpha-fetoprotein and human chorionic gonadotropin have proven useful as tumor markers in some types of germ cell tumors, they have not been useful in patients with dysgerminoma. serum lactic dehydrogenase (LDH) levels are known to be elevated in some patients with dysgerminoma. We treated a patient with Stage IIIC dysgerminoma whose initial serum LDH level was markedly elevated. After unilateral salpingo-oophorectomy with pelvic and paraaortic lymphadenectomy, followed by four cycles of VAC chemotherapy, her LDH level returned to normal. Her LDH level rose with disease recurrence and returned to normal again with salvage BEP chemotherapy. This is the first report to document the utility of serial LDH measurements in detecting disease recurrence in patients with ovarian dysgerminoma.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
6/18. Salvage of relapsed malignant histiocytosis by autologous bone marrow transplant.A 21-year-old female presenting with malignant histiocytosis was initially treated with conventional aggressive chemotherapy resulting in complete remission (CR) but relapsed within 6 months of discontinuation. The patient was reinduced with two cycles of cis-platinum, cytosine arabinoside and mitoxantrone and achieved CR, at which time she received single agent high-dose melphalan followed by autologous bone marrow transplant. She remains in CR 36 months after the autograft procedure.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
7/18. Extrapelvic endometriosis presenting as a hernia: clinical reports and review of the literature.endometriosis is a common gynecologic diagnosis. Typical complaints of patients with pelvic endometriosis include dysmenorrhea, menstrual irregularities, dyspareunia, and infertility. endometriosis may also occur in extrapelvic sites and cause unusual symptoms and diagnostic dilemmas. endometriosis has been described in the inguinal region, and this is illustrated in the first case history. The tender inguinal masses often fluctuate with the menstrual cycle but the condition initially may be confused with an inguinal hernia. Treatment is surgical. abdominal wall scar endometriosis, seen in the second case, has been described in patients after a wide variety of gynecologic procedures. This also is initially noted as a tender mass, usually fluctuating with menstruation, and is often confused with an incisional hernia. Again, surgery is the treatment of choice. Pathologic features of endometriosis are constant, regardless of location. Microscopically, endometrial glands and stroma, fibrosis, chronic inflammation, and old hemorrhage are seen. Familiarity with the unusual types of endometriosis is important to the general surgeon.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
8/18. Resolution of malignant small bowel obstruction after intraperitoneal etoposide therapy.In the case we have reported, abdominal carcinomatosis with malignant small bowel obstruction (due to metastatic lung adenocarcinoma) developed despite ten cycles of cisplatinvinblastine and eight months of treatment with interferon and interleukin-2. etoposide (VP-16) administered intraperitoneally as part of a phase I trial produced dramatic relief of the obstruction.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
9/18. Two cases of endometrioma in cesarean scars.The occurrence of endometrioma in cesarean scar is an infrequent event usually presenting as a tender abdominal wall mass. Two cases are reported here. diagnosis is suggested when the symptoms are cyclic and associated with the patient's menstrual cycle, but this is not always the case. Surgical excision is the method of choice for diagnosing and ultimately treating the lesion.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
10/18. Metastatic endometriosis in abdominal scars.The author presents two examples of metastatic endometriosis occurring in an abdominal scar. These case reports illustrate the two main theories of the pathogenesis of the condition: transportation and metaplasia. The diagnosis is straightforward in the classic case in which a painful mass fluctuates with the menstrual cycle, but a biopsy may be needed to confirm the diagnosis when the history is atypical. The treatment of choice, for those who require treatment, may be hormonal manipulation, surgery or irradiation, or a combination of these.- - - - - - - - - - ranking = 0.25keywords = cycle (Clic here for more details about this article) |
| | Next -> |