1/5. Fetal demise due to herpes simplex virus: an illustrated case report.We report and illustrate a case of fetal demise at 31 weeks caused by fulminant herpes simplex virus (HSV) infection. The 15-year-old mother reported no past history or symptoms of an HSV infection during pregnancy. autopsy revealed extensively ulcerated skin and necrosis of the liver, adrenal glands, brain, and placental membranes. Fluorescent in situ hybridization studies of the lungs, liver, adrenal glands and placenta were positive for HSV, but did not distinguish between HSV-1 and HSV-2. A maternal postpartum blood sample was positive for HSV-2 by immunoblot assay.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |
2/5. Systemic lupus erythematosus and concurrent cytomegalovirus vasculitis: diagnosis by antemortem skin biopsy.A 45-year-old woman with a 4-year history of systemic lupus erythematosus (SLE) developed fever, decreased visual acuity and skin ulceration. A biopsy of a cutaneous ulcer demonstrated small vessel vasculitis with characteristic cytomegalovirus (CMV) inclusions in the vascular endothelium. The presence of CMV was confirmed by dna hybridization immuno-histochemistry. retinal artery vasculitis, previously associated with flares of her SLE, was also noted on ophthalmologic examination. Our case demonstrates that CMV infection can mimic the cutaneous manifestations of collagen vascular disease and that early identification can be made by biopsy of suspicious skin lesions.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |
3/5. Perianal cytomegalovirus ulcer in an hiv-infected patient.A 51-year-old man with acquired immunodeficiency syndrome presented with a perianal ulcer. Histologically there were numerous cytomegalic inclusions within endothelial cells and stomal fibroblasts. cytomegalovirus within infected cells was demonstrated by immunohistochemistry and in situ hybridization. No cytopathic typical of herpes simplex were detected. The ulcer resolved completely after a treatment with ganciclovir.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |
4/5. infection with mycobacterium avium-intracellulare with abscess, ulceration and fistula formation.Infections caused by mycobacterium avium-intracellulare complex are generally manifested as pulmonary disease, osteomyelitis or lymphadenitis, and cutaneous infection is rare. We describe a case of M. intracellulare infection of the skin in a 79-year-old man without apparent immunologically disabling disease or therapy. He had cutaneous infection of the right hand over 10 years, developing a fistula and, finally, an ulcer and abscess, 2 months before his death from heart failure. Mycobacterium intracellulare was identified by both microbiological characteristics and dna-dna hybridization.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |
5/5. skin infection caused by mycobacterium avium.A patient with skin infection due to mycobacterium avium is reported. A 9-year-old female had 10 subcutaneous nodules and two ulcers on the abdomen and legs. She had no medical history of systemic disease, skin disease or immunosuppressive therapy. Cultures of a biopsy specimen and of aspirated seropurulent fluid in nodules showed acid-fast bacteria, identified as M. avium by the dna-dna hybridization method. We treated her with a combination of surgery and the antibiotics, cycloserine, isoniazid and clarithromycin.- - - - - - - - - - ranking = 1keywords = hybridization (Clic here for more details about this article) |