1/35. Familial malignant melanoma.Two sisters simultaneously developed a superficial spreading malignant melanoma on their legs. Concurrently, a brother was affected with fatal metastatic melanoma. Several explanations for familial malignant melanoma are reviewed, including: 1. Genetically determined predisposition; ,2 Phenotypic and environmental factors; and 3. Infectious etiology (virus?). Relatives of patients who develop malignant melanoma spould be aware that they have a higher risk than the general population of developing this serious type of cancer.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
2/35. arsenic-related bowen's disease, palmar keratosis, and skin cancer.Chronic arsenical intoxication can still be found in environmental and industrial settings. Symptoms of chronic arsenic intoxication include general pigmentation or focal "raindrop" pigmentation of the skin and the appearance of hyperkeratosis of the palms of the hands and soles of the feet. In addition to arsenic-related skin diseases including keratosis, bowen's disease, basal-cell-carcinoma, and squamous-cell carcinoma, there is also an increased risk of some internal malignancies. arsenic-related diseases are common in areas of the world where the drinking water has a high arsenic content. In this paper, we describe a 35-year-old male patient who had arsenic-related keratosis, squamous-cell carcinoma in the palmar area of his left hand, and bowen's disease on his left thigh. The patient worked in a borax mine for 15 years, so he was exposed to arsenic in drinking water, airborne arsenic in his workplace, and had direct contact. The patient was treated for 11 months for arsenic-related keratosis until an axillary lymph node metastasis occurred; the lesion was excised and diagnosed to be malignant. bowen's disease was detected when the patient was being treated for cancer. No other malignancy was found. The patient is still receiving regular follow-up care.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
3/35. Cutaneous malignant melanoma: Tabuk experience.Cutaneous melanoma (CM) has a rising morbidity and mortality in the western world but is rare in certain geographical areas including the middle east. The aim of this study is to define the pattern of CM in this environment over a period of about two decades. A review of associated histological reports, dermatology, plastic general surgical admissions and outpatient census statistic of the North West Military Hospital (N.W.A.F.H.) were carried out from January 1978 to June 1996. The clinico-therapeutic information from both the review case and newly discovered CM was then studied. The result shows that CM is probably rare in the Tabuk military environment and possibly has a low mortality among the affected individuals. The presence of only 2 cases of CM among 73,955 patients over about 20 years suggests that this neoplasm is rare in N.W.A.F.H. Surgery, with localised expert reconstruction, probably offers the best cure for uncomplicated CM in this area. It is suggested that the geographical environment, genetic attributes, custom, attitude, presence of white, painted, sun-reflecting buildings, traditional dress-code and behaviour of the indigenes probably contribute to the suppression of and protection against CM in Tabuk. It is recommended that regular, antimlanoma education awareness programmes among the indigenes and avoidance of sunbathing attitude of the expatriate community should be encouraged in order to maintain this suggested natural selection protection.- - - - - - - - - - ranking = 3keywords = environment (Clic here for more details about this article) |
4/35. Cutaneous capillary hemangiomas of the eyelid, scalp, and digits in premature triplets.PURPOSE: To document the unique occurrence of multiple cutaneous capillary hemangiomas in healthy triplets. methods: case reports. RESULTS: triplets born 6 weeks prematurely were noted at birth to have classic cutaneous capillary hemangiomas that enlarged in the first few months of life. At 3 months of age, triplet #1 manifested a small capillary hemangioma on the left index finger and a large hemangioma that involved the entire left upper eyelid and completely occluded the visual axis. Triplet #2 had a small hemangioma on the thumb and a large hemangioma on the scalp of the forehead. Triplet #3 displayed only a minor hemangioma of the right upper eyelid that did not threaten her vision. The parents of the triplets admitted having a history of periocular capillary hemangioma that spontaneously resolved. Triplet #1 was managed with oral corticosteroids, with dramatic regression of the mass and exposure of the visual axis. CONCLUSIONS: Cutaneous capillary hemangioma is usually a sporadic condition. We found this tumor in premature triplets whose parents had a history of a similar tumor. This suggests that hereditary and environmental factors may play a role in the development of this tumor. We advise that medical and family histories be obtained in all children with cutaneous capillary hemangioma.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
5/35. Cutaneous leishmaniasis.The incidence of leishmaniasis is increasing globally due to population and environmental changes. Ease of worldwide travel and immigrant populations means that the UK surgeon is more likely to encounter cutaneous lesions. Two cases are presented and treatment options discussed.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
6/35. Malignant melanoma and lymphoproliferative malignancy: is there a shared aetiology?We report seven patients who developed malignant melanoma either coincident with or before the diagnosis of non-Hodgkin's lymphoma or chronic lymphatic leukaemia. One patient died secondary to leukaemia, and chemotherapy-induced immunosuppression may have contributed to the development of metastatic melanoma in another patient. immunosuppression, exposure to ultraviolet radiation and genetic factors may result in a host environment that is conducive to the development of both tumours in these patients.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
7/35. scabies associated with radiation therapy for cutaneous T-cell lymphoma.scabies, infection with sarcoptes scabiei, is known to be predisposed to by poor body hygiene, environmental exposure, and systemic immunodeficiency. We report the case of an 83-year-old man with Sezary's syndrome who developed scabies limited to the skin of the upper chest, the same location where he had previously received electron beam radiation treatments for cutaneous T-cell lymphoma. Histologic and immunohistochemical studies demonstrated that sections of the previously irradiated right and left chest skin, compared to non-irradiated chest, abdominal, and leg skin, had infestation by scabies, diminished involvement by T-cell lymphoma, and notably reduced numbers of langerhans cells. These findings suggest that the development of scabies may be predisposed to by local cutaneous radiation therapy, and that it may be mediated by local cutaneous immunodeficiency secondary to reduced numbers of langerhans cells.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
8/35. mucor mycosis infection presenting as a non-healing ulcer in an immunocompromised patient.mucor mycosis is an uncommon saprophytic opportunistic fungus causing localized cutaneous infection associated with high morbidity and, on dissemination, high mortality. We report the case of an immunocompromised patient with an aggressively progressing, painful non-traumatic ulceration, unresponsive to standard treatment. Deep biopsies for haematoxylin and eosin staining and fungal culture revealed the characteristic broad non-septate irregular hyphae of mucor allowing introduction of the appropriate treatment. infection with mucor mycosis must be considered in today's medical environment as the number of immunocompromised patients increases.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
9/35. Leukaemia cutis in a patient with acute myelogenous leukaemia: case report.Leukaemia cutis is a specific lesion of leukaemia in which there is leukaemic cell deposit in the skin. There are few reports of this condition in our environment. Several mechanisms have been postulated for the pathogenesis of the disease. One of which is the tissue selective homing of a unique sub-population of malignant clone of cells. The presence of leukaemia cutis does not seem to worsen the prognosis as the acute myeloid leukaemia is an equally lethal disease. The fatality of the disease is compounded by the unavailability of the right regimen in our patient. This paper documents a case of leukaemia cutis in a patient initially diagnosed to have AML who developed skin lesion in remission. A skin biopsy was found helpful in diagnosing the first sign of relapse in a patient in haematological remission.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
10/35. Squamous cell carcinoma of the lower lip: exact location match in siblings.BACKGROUND: In recent years, genetic contribution to the development of skin cancers is under the magnifying glass of several authors and is now regarded as the main initial etiology in carcinogenesis. OBJECTIVE: Two siblings who had squamous cell carcinoma of the lower lip showing an exact location match are presented. patients: They did not share common environmental factors, and there was no history of tobacco and/or alcohol abuse. CONCLUSIONS: It would be scientifically deceptive to draw generous conclusions for the cases here, other than being a very interesting and unusual coincidence, because further evaluation could not be done to scientifically prove a possible genetic contribution.- - - - - - - - - - ranking = 1keywords = environment (Clic here for more details about this article) |
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