1/9. Histopathologic study of the human eustachian tube and its surrounding structures following irradiation for carcinoma of the oropharynx.OBJECTIVE: To describe a histopathologic analysis of a human temporal bone demonstrating patulous changes of the eustachian tube (ET) and its surrounding structures following radiation therapy. DESIGN: Retrospective histopathologic case review and comparison with an age-matched control. SETTING: Elizabeth McCullough Knowles Otopathology Laboratory, University of Pittsburgh School of medicine, Pittsburgh, Pa. RESULTS: A widened patulous ET was verified by demonstrating fibrous tissue replacement of the surrounding supporting structures related to the ET. The ET lumen was patulous and wider than the control case. Ostmann fatty tissue, the levator veli palatini muscle, and submucosal glands around the ET cartilage were replaced by dense connective tissue. CONCLUSION: This is the first histopathologic report, to our knowledge, demonstrating the effects on the ET lumen and supporting structures following acute weight loss, possible tumor infiltration, and radiation changes for carcinoma of the oropharynx.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/9. Solitary fibrous tumor of the parapharyngeal space: MR imaging findings.We report the MR imaging findings of a solitary fibrous tumor involving the parapharyngeal space. The tumor was a well-circumscribed solid mass with a lobulated contour. It had the same signal intensity as the muscle on T1-weighted MR images, heterogeneously high signal intensity on T2-weighted images, and homogeneous strong enhancement after the administration of contrast material. It mimicked a tumor originating from the deep lobe of the parotid gland.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
3/9. Craniofacial defects of blastogenesis: duplication of pituitary with cleft palate and orophgaryngeal tumors.Duplications of organs and/or tissues are rare in morphogenesis and have frequently been attributed to incomplete twinning. To further elucidate the phenotypes associated with organ duplications, we present three infants with duplication of the pituitary gland (DPG). A review of previously reported cases with DPG showed that the commonest additional findings were hypothalamic enlargement, a broad or duplicated sella, cleft palate, hypertelorism, oropharyngeal tumors, agenesis or hypoplasia of the corpus callosum, and abnormalities of vertebrae. DPG and additional malformations constitute a distinct and recognizable pattern of anomalies, which may constitute a polytopic field defect due to splitting of the notochord. However, the precise inductive mechanism resulting in DPG remains unknown.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
4/9. Cancer of the oropharynx developed after radiotherapy and chemotherapy for Hodgkin's disease--a case report.A case of oropharyngeal squamous cell cancer occurring in the radiation field for Hodgkin's disease is reported. The second cancer was diagnosed six years and one month after the patient received 40 Gy/25 fractions. The patient also received salvage chemotherapy two years and six months after the primary radiotherapy. In a review of the world literature, we found 22 cases of head and neck cancer excluding the thyroid gland occurring after radiotherapy alone or radiotherapy combined with chemotherapy for Hodgkin's disease. Although second cancers in the head and neck area after Hodgkin's disease have rarely been reported, those patients cured of the disease should be followed up carefully for a long period of time.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/9. Retropharyngeal mass as a rare presentation of a goiter: CT findings.When sufficiently large, goiters often extend into the mediastinum. Less often, there is extension into the tracheoesophageal groove and the retroesophageal space, and, rarely, there may be growth into the retropharyngeal space. In the latter instance the goiter will present clinically as an oropharyngeal mass in a patient with stridor. We report two similar cases documented with CT studies that clearly show that the origin of the retropharyngeal mass was the thyroid gland.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
6/9. Parapharyngeal mass presenting with sleep apnoea.A 60-year-old man presented with a history of progressive sleep disturbance due to an intraoral parapharyngeal salivary gland tumour. The sleep study performed post-operatively showed rapid resolution of nocturnal hypoxic episodes. This appears to be the first recorded case of a parapharyngeal mass causing sleep apnoea and we review the current literature on obstructive sleep apnoea.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
7/9. Transoral excision of lateral parapharyngeal space tumors presenting intraorally.Six patients with parapharyngeal space tumors presenting intraorally over the past 16 years were managed by transoral excision. All had benign tumors of salivary gland origin (1 monomorphic and 5 pleomorphic adenomas) and 3 of 6 patients were asymptomatic. There were no surgical complications and blood loss was minor in all cases. One patient, who had refused treatment for more than 40 years, presented with dyspnea and dysphagia, and required a tracheotomy for safe induction of anesthesia. Only one patient was hospitalized for more than 3 days and only one tumor recurred--as a malignant pleomorphic adenoma 3 years later.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
8/9. Dissection of parapharyngeal space in head and neck cancer.The parapharyngeal space is a potential space located lateral to the upper pharynx and tonsillar area. This space can be involved either by direct extension, by perineural or neural spread, or by lymph node metastasis from cancers originating in adjacent sites. Between 1978 and 1984, 22 patients with T3 or T4 carcinoma of the head and neck region underwent dissection of the parapharyngeal space in conjunction with ablation of the primary tumor and standard radical neck dissection. Twelve of these patients had carcinoma arising in the oral cavity, 4 in the oropharynx, and 6 in the major salivary glands. Surgical approaches applied to the dissection of the space were the submandibular route combined with the transoral approach in 1 patient, transparotid in 3, the mandibular "swing" approach in 9, and mandibular composite resection in 9. The last 2 approaches allowed excellent control of the neurovascular structures up to their entrance into the skull base. In 18 patients of this series, the tumor was locoregionally controlled in 5 to 77 months (median 23 months) of follow-up. Dissection of the parapharyngeal space improves locoregional control rate of advanced head and neck cancers involving this space.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
9/9. Oropharyngeal hairy polyp with meningothelial elements.The so-called hairy or teratoid polyp is a rare lesion of bigerminal origin that comprises elements derived from both ectodermal and mesodermal cell lines. In this article we report the presence of meningothelial elements in a hairy polyp, a previously undescribed component of this entity. The lesion was characterized by a pedunculated outgrowth from the hard palate. The surface of the outgrowth was covered by squamous epithelium and a central core of fibroadipose tissue, pilosebaceous glands, cleftlike pseudovascular spaces, and groups of epithelioid cells. These reticulated and cellular foci had the immunohistochemical and ultrastructural features of meningothelial tissue.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |