1/4. nicorandil can induce severe oral ulceration.OBJECTIVE: To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration. STUDY DESIGN: Nine new cases of ulceration from 3 European countries were included in this study. RESULTS: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia. CONCLUSIONS: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.- - - - - - - - - - ranking = 1keywords = physician (Clic here for more details about this article) |
2/4. Secondary syphilis-related oral ulcers: report of four cases.Establishing a diagnosis of syphilis, whatever the stage of the disease, can be difficult because syphilis is a great mimic in clinical morphology and histology. Many patients infected with venereal diseases have oral manifestations, but very few dentists and physicians have the proper experience to diagnose syphilis or other STDs from oral lesions. Oral secondary syphilis appears to be very uncommon, and few cases have been reported over the recent past. We present 4 patients who developed secondary syphilis-related oral lesions of moist ulcers, irregular linear erosions termed 'snail-track' ulcers, or erythematous mucous patches on the labial mucosa, buccal mucosa, palate, or tongue. Concurrent human immunodeficiency virus (hiv) infection was diagnosed in 1 patient. The histological examination in 2 patients showed dense subepithelial inflammatory cell infiltration comprised predominantly of plasma cells, and it was of practical help in the diagnosis of syphilis. The diagnostic value of a histological examination, serologic tests, and treatment of syphilis are discussed. Obviously, coinfection with hiv will complicate the clinical presentation, diagnosis, and management of syphilis. Concurrent hiv infection should be considered in any patient with a sexually transmitted disease including syphilis.- - - - - - - - - - ranking = 1keywords = physician (Clic here for more details about this article) |
3/4. sarcoidosis with gingival involvement: a case report.BACKGROUND: The case outlined is a rare presentation of sarcoidosis intraorally associated with gingival ulceration. methods: The diagnosis was made following a gingival biopsy. RESULTS: The patient was subsequently referred to a physician for clinical management and the condition resolved without active treatment. CONCLUSIONS: sarcoidosis should be considered in the differential diagnosis of persistent swellings and ulceration of the oral mucosa. Intraoral sarcoid lesions are often the first indication of systemic involvement. It is important to make the diagnosis and monitor the condition as sarcoidosis is progressive if untreated in a small number of those affected.- - - - - - - - - - ranking = 1keywords = physician (Clic here for more details about this article) |
4/4. Mucocutaneous manifestations of the hyper-igm immunodeficiency syndrome.BACKGROUND: The recurrent pyogenic infections of patients with hyper-IgM syndrome are controlled by intravenous gamma globulin administration, but patients may suffer from early-onset oral ulcerations and warts. OBJECTIVE: We have characterized the mucocutaneous manifestations associated with this condition to allow physicians to more readily identify it. methods: Three male patients with the mucocutaneous manifestations of the hyper-IgM syndrome are described. In one, histopathologic examination of the oral mucosal lesion was performed. RESULTS: Recurrent large, painful oral ulcerations can occur that are not necessarily associated with neutropenia nor do they respond to granulocyte colony-stimulating factor administration. Histopathologic examination of an ulcer showed a heavy infiltrate of mixed inflammatory cells. warts tend to be widespread and resistant to traditional therapy. CONCLUSION: physicians should consider this uncommon condition when examining a male patient with severe oral ulcers or recalcitrant widespread warts.- - - - - - - - - - ranking = 1keywords = physician (Clic here for more details about this article) |