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1/7. tissue plasminogen activator in pediatric myocardial infarction.

    Children rarely present to emergency physicians during an acute myocardial infarction. However, this may occur in the setting of Kawasaki disease with thrombosed coronary aneurysms. We present the first case in which intravenous tissue plasminogen activator was used to successfully treat a 7-year-old child having an acute myocardial infarction caused by a thrombosed coronary aneurysm.
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2/7. Incomplete Kawasaki disease with recurrent skin peeling: a case report with the review of literature.

    Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that has largely replaced rheumatic heart disease as a cause of acquired heart disease in children of many developed countries. We report a case of incomplete KD in a five-year-old girl. The diagnosis of incomplete KD was made after exclusion of conditions with similar presentation. She was treated with intravenous immunoglobulin following which she made an uneventful recovery but demonstrated thrombocytosis in the second week of convalescence. During the six-month follow up period, she had two episodes of recurrent skin peeling a phenomenon, which is recently reported with KD but not with atypical or incomplete KD. It is important for the treating physicians to become aware of the incomplete KD as prompt diagnosis and early treatment of these patients with intravenous immunoglobulin is vital for the prevention of lethal coronary complications. physicians need to have a "high index of suspicion" for KD and even, higher for IKD.
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3/7. facial nerve paralysis associated with Kawasaki disease.

    Kawasaki disease is a multisystem disorder with varying clinical expression. This is a report on one case of Kawasaki disease which during its clinical course developed facial nerve palsy and spontaneous recovery without specific treatment. It is hoped that this report will serve to remind physicians of the association of facial nerve paralysis with Kawasaki disease.
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4/7. myositis in Kawasaki disease.

    myositis is recognized as one of several neurologic complications encountered in Kawasaki disease. We report an unusual patient with Kawasaki disease which was complicated by severe myositis and respiratory failure secondary to weakness. Comparison of our patient with previously reported cases leads us to conclude that myositis in Kawasaki disease usually is present within 1-3 weeks of illness; the symptoms usually are mild and probably remain unnoticed by most physicians, but weakness can be severe and respiratory failure may occur. The degree of creatine kinase elevation may be useful in predicting the severity of myopathy and in alerting the physician to the need for close respiratory monitoring. Therapy is supportive and complete recovery is to be expected.
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5/7. mucocutaneous lymph node syndrome in Calabar--a case report.

    A four and a half-year old Nigerian girl, living at home, who presented with protracted fever, multifocal lymph node enlargement, extensive scaly rash, injected conjunctivae, fissuring of the lip and other features consistent with a diagnosis of Kawasaki disease is reported. This disease, first seen in japan and then other parts of the world including black africa has not yet been reported in nigeria. child care physicians in nigeria are hereby cautioned to look out for this unusual disease.
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6/7. Kawasaki disease.

    Kawasaki disease is an acute, multisystem illness that predominantly affects young children and has been described throughout the world. The triphasic course includes an initial phase of acute illness marked by high fever, conjunctival injection, oral changes, and erythematous rash. The second, subacute, phase begins with a decline of the acute findings and proceeds with desquamation of rash, joint manifestations, thrombocytosis, and cardiac disease. Most deaths (1 to 2 percent of cases) occur in this phase, usually resulting from myocardial infarction. During the third phase all signs of clinical illness subside. The prognosis is related to the degree of cardiac involvement, and 14 to 20 percent of patients develop coronary artery aneurysms. Inhibition of platelet aggregation, combined with symptomatic relief and supportive measures, forms the cornerstone of therapy. family physicians need to be aware of this illness, particularly since it can no longer be considered rare.
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7/7. Sudden death in a young adult: sequelae of childhood Kawasaki disease.

    A case of sudden cardiac death in a young adult secondary to sequelae of childhood Kawasaki disease is presented. At autopsy, proximal coronary artery aneurysms typical of Kawasaki disease with recent and remote myocardial infarction was found. Although the acute diagnosis and management of Kawasaki disease has received attention in recent literature, little has been written about the implications of the disease in long-term survivors. Serious morbidity and mortality many years after the acute phase of the disease can occur. Because of the relatively recent recognition of the disease, an undetermined population of patients with previously unrecognized Kawasaki disease exists. Young patients with previous Kawasaki disease may have severe stenotic coronary disease that may be asymptomatic and present with sudden cardiovascular symptoms or death. Acute care physicians should be cognizant of these issues and should seek specific information regarding childhood illnesses when evaluating the young patient with acute cardiovascular symptoms.
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