1/5. Lipedematous alopecia: a clinicopathologic, histologic and ultrastructural study.Lipedematous alopecia is a rare condition of unknown etiology characterized by a thick, boggy scalp with varying degrees of hair loss that occurs in adult black females, with no clearly associated medical or physiologic conditions. The fundamental pathologic finding consists of an approximate doubling in scalp thickness resulting from expansion of the subcutaneous fat layer in the absence of adipose tissue hypertrophy or hyperplasia. Observations by light and electron microscopy detailed in this report suggest that this alteration principally manifests by localized edema with disruption and degeneration of adipose tissue. Some diminution in the number of follicles as well as focal bulb atrophy is noted. Aberrant mucin deposition such as that seen in myxedema or other cutaneous mucinoses is not a feature. The histologic findings bear some resemblance to those seen in lipedema of the legs, a relatively common but infrequently diagnosed condition. We present a case of lipedematous alopecia with emphasis on histologic and ultrastructural features. The etiology is unknown.- - - - - - - - - - ranking = 1keywords = hyperplasia (Clic here for more details about this article) |
2/5. Lymphoedema due to lymphatic hyperplasia: a case report.An unusual case of generalised lymphoedema is described. The congenital nature of the lymphatic anomaly and the significance of its lymphographic appearance are discussed.- - - - - - - - - - ranking = 4keywords = hyperplasia (Clic here for more details about this article) |
3/5. Squamous carcinoma of the foot arising in association with long-standing verrucous hyperplasia in a patient with congenital lymphedema.A patient is reported with congenital lymphedema who developed a squamous cell carcinoma on his affected foot. Parallels are drawn between the development of a squamous cell carcinoma with condylomatous and spindle cell features arising in a setting of long-standing verrucous hyperplasia, as seen in this patient, and the well-recognized phenomenon of angiosarcoma occurring in areas of lymphangiomatous proliferation in patients with chronic lymphedema. The importance of a random genetic mutation occurring in hyperplastic tissue in an immunologically privileged site is discussed. Additional consideration is given, in the current case, to the possibility of viral oncogenesis and the role of ulceration as a promoter factor.- - - - - - - - - - ranking = 5keywords = hyperplasia (Clic here for more details about this article) |
4/5. Persistent purple plaques of the face caused by gingival hyperplasia.Persistent plaques that develop primarily on the face may be caused by a variety of conditions, but rarely is purely intraoral infection the primary cause. A case report is presented in which massive prolonged gingival hyperplasia resulted in a persistent and peculiar purple facial lymphedema. The condition resolved only after the intraoral disease had been successfully treated.- - - - - - - - - - ranking = 5keywords = hyperplasia (Clic here for more details about this article) |
5/5. Masson's intravascular papillary endothelial hyperplasia mimicking Stewart-Treves syndrome: report of a case.Masson's intravascular papillary endothelial hyperplasia, also called Masson's pseudoangiosarcoma, represents a benign vascular proliferation, presently considered as a peculiar histopathologic reaction pattern of the endothelium to diverse stimuli. Differentiation from angiosarcoma represents the main diagnostic concern. We report a case of Masson's intravascular papillary endothelial hyperplasia presenting in a 55-year-old woman with ipsilateral lymphedema secondary to surgery and radiation therapy for breast carcinoma. The diagnosis was intravascular papillary endothelial hyperplasia. This is the first description of Masson's pseudoangiosarcoma in this clinical context, to our knowledge. We believe it represents a peculiar morphologic pattern of endothelium proliferation secondary to venous stasis and thrombosis due to lymphedema.- - - - - - - - - - ranking = 7keywords = hyperplasia (Clic here for more details about this article) |