1/16. stevens-johnson syndrome. Description of an unusual clinical case due to glucocorticoid therapy for oral lichen planus.erythema multiforme (EM) is an acute inflammatory disease with an autoimmune pathogenesis clinically expressing in a wide variety of mucocutaneous illnesses. It is usually described in a minor form (Von Hebra) characterized by classical cutaneous lesions, and in major form (Stevens-Johnson), involving mucosal damage, while a clinical type restricted to the oral mucosa is described in oral pathology. A considerable number of factors of different nature have been reported as etiologic agents of EM, but most of them are not well documented; however, a certain relationship with EM is recognized for different classes of systemic drugs. This paper describes a case of stevens-johnson syndrome with initial oral involvement, in which the precipitating factor was due to the administration of systemic glucocorticoids, prescribed for the therapeutic treatment of an erosive form of oral lichen planus.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
2/16. lichen planus occurring after hepatitis B vaccination: a new case.lichen planus is a pruritic inflammatory dermatosis of unknown origin. An increased prevalence of a wide range of liver disease in lichen planus has been observed by many authors. Most recently, many reports appeared of the occurrence of lichen planus after administration of different types of hepatitis b vaccines. We report one case and briefly review this intriguing observation.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
3/16. Generalized lichen planus in childhood: is dapsone an effective treatment modality?Childhood lichen planus is generally atypical in appearance, prolonged in duration and resistant to therapy. Moreover, the risk in administration of systemic drugs because of several adverse effects limits their use and effective therapy remains a problem in this age group. We report a case of generalized lichen planus in a nine-year-old boy with oral mucosa and nail involvement who was treated with dapsone.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
4/16. Treatment of gingival lichen planus with a free gingival graft: a case report.lichen planus is an inflammatory dermatosis affecting the skin and mucous membrane. In oral lichen planus, the gingival tissue is often involved. Treatment is symptomatic and depends mostly on the administration of corticosteroids and tranquilizers. This report presents the case of a patient with gingival lichen planus who was treated with free gingival graft. Followup after 3 1/2 years showed that the lesions had completely disappeared.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
5/16. gold sodium thiomalate (GTM) induces hypersensitivity to thiomalate, the thiol carrier of GTM.A case of the gold sodium thiomalate (GTM)-induced eruptions with thiomalate (TM) hypersensitivity was reported. A 61-year-old Japanese woman developed lichenoid and seborrheic dermatitis (SD)-like eruptions with alopetia, when the total dosage of GTM administered for rheumatoid arthritis became 110 mg. The eruptions slowly disappeared with pigmentation after discontinuance of the GTM therapy, and the resumption resulted in the development of similar eruptions. She showed a positive reaction to GTM in an intradermal test. She also showed a positive response to TM, which is the thiol carrier of GTM, in the patch test, but a negative one to metallic gold. After administration of auranofin (AF), she also developed the SD-like eruptions with hypersensitivity to metallic gold as well as AF on patch testing, but did not develop the lichenoid ones. Our animal experiments revealed an almost complete cross reaction between GTM and TM, but only a partial one between GTM and aurothioglucose, which have dissmilar structures in the carrier part for gold. Probable roles of hypersensitivity to TM and metallic gold, which are metabolites of GTM, were discussed, respectively, in the genesis of the GTM-induced lichenoid eruptions and the AF-induced SD-like eruptions.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
6/16. Interferon activity and its characterization in the sera of patients with premalignant lesions arising in oral mucosa.The interferon (IFN) assay of the sera from the 26 patients with premalignant lesions such as lichen planus and leukoplakia arising in oral mucosa was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. When the serum IFN activity was characterized by acid treatment, significant increase of acid-stable IFN in the patients was found as compared with those in the normal controls. The titers of gamma-like IFN defined by anti-HuIFN-alpha and anti-HuIFN-beta in the sera of patients of 50-79 years age group (n = 17, P less than 0.002) showed a highly significant increase as compared with the relevant normal controls (n = 20). All of the 26 patients were treated with topical administration of HuIFN-beta. When the correlation between prognosis of the disease and titers of serum IFN was investigated by measuring gamma-like IFN and acid-stable IFN in the sera of patients, all of 13 patients with good prognosis after the HuIFN-beta therapy showed significantly decreased levels of gamma-like IFN (P less than 0.01), whereas the serum level of acid-stable IFN after HuIFN-beta therapy showed a significant increase compared to that before the therapy (P less than 0.05). These findings indicate that the endogenous IFN system may be associated with the pathophysiology in patients with the oral mucosal lesions.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
7/16. Therapeutic effect of human fibroblast interferon on premalignant lesions arising in oral mucosa. A pilot study.Human fibroblast interferon (HuIFN-beta) was topically administered to 20 premalignant lesions histopathologically showing epithelial dysplasia such as leukoplakia and lichen planus which arose in the oral mucosa. HuIFN-beta was prepared in the water-soluble gel form containing 2% carboxymethylcellulose, 45% glycelin, 0.1 M citrate buffer (pH 4.5) and 0.2% SDS as stabilizing agents. This preparation was found to be effective for herpetic gingivostomatitis and zostal lesions arising along the intercostal nerve. Thus, the HuIFN-beta preparation (10(4) to 5 X 10(3) IU) was applied to the oral mucosal lesion for 1 h twice a week. The lesion with topical administration of HuIFN-beta was covered tightly with the mucosal bandage which was coated with carboxymethylcellulose, glycelin and CaCl2 on vinyl acetate matrix. The 14 oral lesions with erosion or ulcer formation accompanied by severe pain by touch, had complete remission after approximately 10 successive applications of this preparation. Although subjective symptoms such as irritation pain in the other 6 patients with severe hyperkeratotic lesion subsided, white coatings and streaks could not be completely removed by this therapy. No other side-effects excluding slight pain and reddish swelling which occurred intermittently during HuIFN-beta administration were observed.- - - - - - - - - - ranking = 2keywords = administration (Clic here for more details about this article) |
8/16. Lichen ruber mucosae with esophageal involvement.The clinical course of a 50-year-old woman with oral lichen ruber planus (Irp) and prolonged dysphagia is described. The swallowing problems of this patient were related to an inflammatory lesion of the middle third of the esophagus, leading to stenosis. Distal to this area, the esophagus was covered with mucosa of the cardia type, as seen in endobrachyesophagus. Apart from reflux disease, the Irp may have accounted for the stenosis of the mid-esophagus. The mucosal lesions disappeared after administration of etretinate (Tigason). After endoscopic dilatation the patient was able to swallow normally again.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
9/16. Photosensitivity due to a fluorouracil derivative.A photosensitive lichen planus-like eruption developed in a 63-year-old man during postoperative chemotherapy with 1-(2-tetrahydrofuryl)-5-fluorouracil. The action spectrum for the photosensitivity was in the long-wave ultraviolet light (UV-A). The reaction was reproducible on readministration of the drug and exposure to UV-A. At the time of this test, a flare-up phenomenon was observed at previously involved sites. The photopatch test was negative with the drug. patients taking the drug who had no dermatitis were not sensitive to UV-A. These observations suggest that the photosensitivity that occurred in the patient was possibly photoallergic.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
10/16. lichen planus pemphigoides-like lesions induced by cinnarizine.A 72-year-old woman developed a lichen planus pemphigoides-like eruption following the administration of cinnarizine. The eruption recurred on challenge with the drug. Direct immunofluorescence studies of the lesions demonstrated deposition of IgG, IgM and C3 on colloid bodies and fibrin at the epidermal basement membrane zone. Circulating IgG antibasement membrane zone antibodies were detected at high titres, with no complement-fixing activities. To our knowledge, this is the first report of immunologically defined lichen planus pemphigoides induced by a drug.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
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