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1/47. Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage.

    In this pilot study we treated cerebral vasospasm in patients with subarachnoid haemorrhage to assess intra-arterial fasudil hydrochloride. We analysed effects of intra-arterial infusion on angiographically evident cerebral vasospasm in 10 patients including 3 with symptoms of vasospasm. Over 10 to 30 min 15 to 60 mg was administered via the proximal internal carotid artery or vertebral artery following standard angiography, without superselective techniques. A total of 24 arterial territories (21 internal carotid, 3 vertebral) were treated. Angiographic improvement of vasospasm was demonstrated in 16 arterial territories (local dilation in 2, diffuse dilation in 14) in 9 patients. In 2 symptomatic patients, intra-arterial fasudil hydrochloride was associated with resolution of symptoms without sequelae. In the third symptomatic patient the benefit of fasudil hydrochloride was only temporary, and a large cerebral infarction occurred. All asymptomatic patients showed no progression of angiographic to symptomatic vasospasm after treatment with intra-arterial fasudil hydrochloride. No adverse effect was encountered.
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ranking = 1
keywords = haemorrhage
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2/47. Unidirectional dyslexia in a polyglot.

    Alexia is usually seen after ischaemic insults to the dominant parietal lobe. A patient is described with a particular alexia to reading Hebrew (right to left), whereas no alexia was noted when reading in English. This deficit evolved after a hypertensive right occipitoparietal intracerebral haemorrhage, and resolved gradually over the ensuing year as the haematoma was resorbed. The deficit suggests the existence of a separate, language associated, neuronal network within the right hemisphere important to different language reading modes.
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ranking = 0.29092752371336
keywords = haemorrhage, haematoma
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3/47. Carotid ligation for carotid aneurysms.

    Thirty patients with subarachnoid haemorrhage due to rupture of a carotid aneurysm were treated by ligation of the common carotid artery. Two patients died as a result of the procedure, two patients developed persisting hemisphere deficit. Eight of the ten patients who developed cerebral ischemia after the operation were operated within ten days after the bleeding. At present out aim is to guide the patient safely through the first ten days after his haemorrhage and perform ligation at the end of the second week. After a follow up period of 1-8 years recurrent haemorrhage did not occur. Common carotid ligation, preferably with control of carotid artery end pressure, cerebral blood-flow and EEG is considered to be a valuable method to treat ruptured intracranial carotid aneurysm.
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ranking = 0.6
keywords = haemorrhage
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4/47. Subdural hematoma mimicking a transient ischemic attack due to antihypertensive medication.

    An elderly man had two completely reversible episodes of aphasia, each occurring after taking his antihypertensive medications. He was subsequently found to have a subdural hematoma. The association between subdural hematomas (and other intracranial mass lesions) and reversible neurologic deficits is discussed, as is the pathophysiology of the phenomenon. In addition, the relationship between the effects of the patient's antihypertensive medications and the neurologic deficits in the setting of a subdural hematoma is explored.
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ranking = 1.2341502078428
keywords = subdural
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5/47. Chronic subdural haematoma presenting with transient ischaemic attacks--a case report.

    We report a middle-aged man who presented with repeated episodes of transient ischaemic attacks (TIA) in the setting of a chronic subdural haematoma. This case report discusses the various pathophysiologic mechanisms whereby such TIA may occur in chronic subdural haematoma. We also highlight the importance of cranial imaging in cases of TIA.
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ranking = 6.9039733997355
keywords = subdural haematoma, subdural, haematoma
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6/47. Transient ischaemic attacks and stroke.

    stroke is the third most common cause of death and a major cause of disability in australia. Effective prevention is the most powerful strategy for reducing the burden of stroke. Major modifiable causal risk factors for stroke include hypertension, cigarette smoking, diabetes, atrial fibrillation, and carotid stenosis. atrial fibrillation, in particular, is under-treated in the community; almost all patients should be prescribed warfarin or aspirin, depending on their absolute risk of stroke and risk of bleeding complications. patients with suspected acute stroke should be referred immediately to a specialist stroke unit for urgent assessment and care by an interested, organised, multidisciplinary team of stroke experts. They should undergo immediate computed tomography brain scan and, if intracranial haemorrhage is excluded, be given aspirin (160-300 mg). rehabilitation and secondary prevention of recurrent stroke should begin on day one after stroke.
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ranking = 0.2
keywords = haemorrhage
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7/47. The importance of identifying intracranial haemorrhage as a cause of transient focal neurological symptoms.

    Until recently, there have been no reports of intracerebral haemorrhage presenting with transient neurological symptoms. We present two cases of intracerebral haemorrhage presenting as transient ischaemic attacks and discuss the radiological changes on early and late CT scans. It would seem justified to scan most patients presenting with TIA early to institute appropriate secondary prevention measures.
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ranking = 1.2
keywords = haemorrhage
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8/47. Chronic subdural hematoma presenting with symptoms of transient ischemic attack (TIA): a case report.

    Rarely, chronic subdural hematomas (CSDH) will present with symptoms mimicking transient ischemic attacks (TIAs). We report the case of an elderly man who presented with intermittent numbness and weakness of his left upper extremity typical of symptoms arising from a right sensorimotor cortex TIA. He was treated with empiric antiplatelet therapy for several days before a head CT was performed. The head CT and a subsequent MRI showed a CSDH with an acute component and cortical compression. Upon evacuation of the hematoma, his symptoms resolved. In cases of suspected TIA, a head CT should always be performed before beginning antiplatelet therapy. If there is an underlying hematoma, such therapy is dangerous, as it can potentiate more bleeding and leave the true pathology unaddressed.
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ranking = 2.0569170130713
keywords = subdural
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9/47. Transfemoral, transvenous embolisation of dural arteriovenous fistula involving the isolated transverse-sigmoid sinus from the contralateral side.

    Background: A dural arteriovenous fistula (AVF) involving the transverse-sigmoid (T-S) sinus which is occluded at its proximal and distal ends i.e., an isolated sinus, runs the risk of haemorrhaging or causing serious neurological deficits as a result of its retrograde leptomeningeal venous drainage. While lesions of this type have not been considered to be treatable by percutaneous, transvenous embolisation, this paper challenges this view. Case Presentation: Two middle-aged men with dural AVFs involving the isolated left T-S sinus presented with motor aphasia due to focal brain edema or haemorrhage. Under local anaesthesia, transfemoral, transvenous embolisation was performed with a microcatheter that was passed through the occluded proximal transverse sinus from the right (contralateral) side. The isolated sinus was then occluded with platinum coils. This embolisation resulted in angiographic and clinical cure of dural AVFs in both patients. Interpretation: Transfemoral, transvenous embolisation is a therapeutic alternative for the treatment of dural AVFs involving the isolated T-S sinus. Embolisation obviates the need for craniotomy and general anaesthesia, which are required for the established modes of treatment, i.e., direct surgery or direct percutaneous sinus packing.
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ranking = 0.2
keywords = haemorrhage
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10/47. What is causing crescendo transient ischemic attacks?

    BACKGROUND AND methods: We discuss a case report from a patient who had symptoms of transient neurological deficits in the presence of a chronic subdural hematoma and severe carotid stenosis. Multi-modality imaging was used to guide management. RESULTS: The symptoms settled without carotid intervention and were presumed due to the subdural hematoma. CONCLUSIONS: Severe symptomatic carotid stenosis is treated with carotid endarterectomy. In some patients with transient neurological deficits, the diagnosis is not as simple as first thought. Multi-modality imaging (MRI, TCD and CT) can help differentiate the causative lesion.
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ranking = 0.82276680522854
keywords = subdural
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