11/44. Recurrent herpes labialis during isotretinoin therapy: is there a role for photosensitivity? isotretinoin (13-cis-retinoic acid) is one of the synthetic retinoids derived from vitamin a. vitamin a derivatives demonstrate virucidal activity, both in vivo and in vitro. isotretinoin has been used for the treatment of recurrent herpes simplex with encouraging results. However, we present a case with frequent attacks of herpes labialis during isotretinoin therapy for acne, who had a marked decrease in frequency of recurrences following strict use of sunscreens. ( info) |
12/44. acupuncture treatment for herpes simplex infections. A clinical case report. herpes simplex is a common skin disorder. There is no effective cure. The recent introduction of drugs, such as acyclovir, is indeed a great advance in its therapeutics. However, these drugs may only modestly reduce the length of an attack, but do not lengthen the remission nor prevent recurrences. Our very limited experience in two cases of herpes oral-labialis and three cases of herpes genitalis with acupuncture treatment seemed to indicate the possibility of a marked reduction of an episode, a lengthening of the remission, and a prevention of recurrences. We hope our report would encourage our colleagues to try acupuncture in the clinical management of herpes cases and to study its immunologic effects. ( info) |
| The myelodysplastic syndromes are a heterogenous group of hematologic disorders of myeloid progenitor cells. oral manifestations may be among the first signs and often reflect degrees of neutropenia or neutrophil dysfunction. A patient with persistent herpes labialis and severe oral mucosal ulceration in myelodysplastic syndrome is reported. The features of myelodysplasia are reviewed and their oral manifestations and significance to dental management outlined. ( info) |
14/44. herpes simplex labialis and trigeminal neuropathy. Three patients had a transient trigeminal sensory disturbance associated with an ipsilateral herpes simplex (HS) labialis lesion. These cases support the theory that isolated trigeminal sensory disturbance may be caused by intermittent reactivation of HS virus in the trigeminal ganglion. ( info) |
15/44. Restriction endonuclease digestion analysis of dna from viruses isolated from different sites of two fatal cases of herpes simplex virus type-1 infection. herpes simplex virus (HSV) type-1 was isolated from a fatal case of herpes simplex encephalitis (case 1) and from a fatal case of disseminated herpes simplex (case 2). The virus was isolated from the lip lesion, the frontal lobe and the temporal lobe of the brain in case 1 and from a mesenteric node, myocardium and salivary gland in case 2. Restriction endonuclease digestion analysis showed that each case was infected with different substrains of HSV. The changes in band pattern in isolates from case 1 occurred in the "variable" region of the genome, showing that viruses with such variations can be isolated simultaneously from different tissues. The changes in band patterns in isolates from case 2 indicated the presence of two virus substrains, one in the mesenteric node and salivary gland and a second in the myocardium. ( info) |
16/44. Chronic indolent orofacial herpes simplex virus infection in chronic leukemia: a report of three cases. Orofacial mucocutaneous infections caused by herpes simplex virus (HSV) may exhibit a distinct chronic indolent pattern of behavior in some immunosuppressed patients as opposed to the more familiar aggressive patterns. Three patients with chronic leukemia who illustrate this chronic indolent pattern are presented. These cases should alert the clinician to the variable clinical appearance that HSV may adopt in the immunosuppressed patient. ( info) |
17/44. Long-term suppression of recurrent herpes labialis by low-dose oral acyclovir in an immunocompromised patient. A patient with chronic lymphocytic leukemia and severe and frequently recurring herpes labialis received oral acyclovir for more than 18 months, during most of this period at a low dosage (400 mg/d). This regimen was fully successful in preventing recurrences, with no adverse effects. ( info) |
18/44. Multiple oral and labial ulcers in an immunocompromised patient. herpes simplex virus infections in immunocompromised individuals have clinical features that are often quite different from primary and secondary HSV infections in otherwise healthy people. These infections should be recognized early and treated promptly to prevent progression of the lesions and the possible systemic dissemination of the virus. Cytological and biopsy examination frequently discloses changes characteristic of HSV-1, HSV-2, or Varicella-zoster virus. To ensure the most precise diagnosis, however, these examinations should be complemented by viral isolation and serological studies. ( info) |
| herpes simplex virus is the single most common precipitator of erythema multiforme. Typically, erythema multiforme lesions appear 10 to 14 days after a recurrent herpes simplex virus infection and attacks can be disabling when they occur at frequent intervals. Prior to the introduction of acyclovir (Zovirax), there was no effective therapy to prevent herpes-associated erythema multiforme. Four patients were treated with a maintenance dose of acyclovir for periods ranging from 10 to 26 months; there were no significant side effects from the drug and only one recurrence of erythema multiforme. Oral acyclovir may become the treatment of choice for herpes-associated erythema multiforme. ( info) |
20/44. Allergic contact dermatitis to dyclonine hydrochloride simulating extensive herpes simplex labialis. Two patients developed allergic contact dermatitis to 1% dyclonine hydrochloride gel, a nonprescription topical anesthetic widely marketed for the symptomatic treatment of herpes simplex labialis. Both patients mistakenly believed that the eruption was expanding herpes simplex labialis, which resulted in their more frequent application of the dyclonine hydrochloride and a delay in diagnosis. Dermatologists should recognize that 1% dyclonine hydrochloride gel can cause allergic contact dermatitis that can masquerade as widespread herpes simplex labialis. ( info) |