1/9. A case of nasopharyngeal actinomycosis leading to otitis media with effusion.Nasopharyngeal actinomycosis is extremely rare, and to our knowledge, only seven cases have previously been reported. diagnosis of actinomycosis is made by clinical finding, observation of the bacteria and histopathological examination. Treatment for actinomycosis is surgical debridement and administration of antibioticus, especially penicillin for several weeks with good prognosis. We report a case of nasopharyngeal actinomycosis, which lead to otitis media with effusion. Endoscopic surgery and prolonged penicillin administration for 2 months were effective for treatment of actinomycosis in the nasopharynx.- - - - - - - - - - ranking = 1keywords = administration (Clic here for more details about this article) |
2/9. platinum chemotherapy, radiotherapy and the inner ear: implications for "standard" radiation portals.In this centre, platinum chemotherapy precedes radiotherapy in several primary malignancies arising in structures adjacent to the mastoid bone. The augmented ototoxicity of platinum and radiotherapy to fields encompassing the inner ear is exemplified by a case report. The order of administration may not be critical. This important toxicity, particularly for young patients, may be reduced by careful shielding considerations during planning of radiation portals, as exemplified in two further cases, and by carboplatin chemotherapy.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |
3/9. Amyloid goiter and arthritides after kidney transplantation in a patient with systemic amyloidosis and Muckle-Wells syndrome.A case of hereditary AA amyloidosis with Muckle-Wells syndrome is described. After a successful kidney transplantation for chronic renal failure due to renal amyloid deposits at age 21, the patient, a white female now 26 years of age, developed a large amyloid goiter as a manifestation of the systemic amyloidosis and recurrent monarthritides. Both observations are novel for this disease. Subtotal thyroidectomy and oral colchicine administration, known to be effective in preventing complications of familial mediterranean fever, another hereditary type of AA amyloidosis, proved highly effective in the management of this unusual case.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |
4/9. Treatment of hydropic patients by immunoglobulin with methyl B12.Recently several investigations have been reported suggesting that the cause of endolymphatic hydrops might be an immunologic disorder of the endolymphatic space, including the endolymphatic sac. As the first choice in a conservative treatment by medication, the authors have used a combination of prednisolone and furosemide per os, which is rather safe and effective for hydrops patients in a subacute stage. However, some patients do not respond to this treatment or gradually become immune to this medication. With these patients, we have tried an intravenous administration of immunoglobulin g with methyl B12, expecting a curative effect on immunologic deficiency in the endolymphatic space. Compared with a group of patients without this treatment, the group receiving it showed rather good scores in hearing improvement; however, vertigo and tinnitus remained almost unchanged.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |
5/9. Clinical features of cisplatin vestibulotoxicity and hearing loss.patients treated with cisplatin were observed in an otoneurological study with special reference to cochlear and vestibular toxicity. Toxicity-related symptoms appeared to be almost all transient. As with leukopenia, hearing loss and dizziness often occurred after several weeks of administration. In the equilibrium examinations, some abnormal findings such as spontaneous nystagmus and positional nystagmus were seen. caloric tests and body sway tests detected abnormal findings in the early stages of cisplatin-related vestibulotoxicity.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |
6/9. The importance of high-tone audiometry in monitoring for ototoxicity.Early detection of ototoxicity is of vital importance in cases in which ototoxic drugs are administered. Ototoxicity as a result of cis-platinum administration is well documented. Auditory damage may be reduced by changes in dose, drugs or methods of treatment. As ototoxicity appears to be most pronounced in the higher frequencies of sound, any changes can be assessed at an earlier stage by using high-frequency audiometry to test patients at frequencies from 8 to 20 kHz. Our present study demonstrates the utility of monitoring auditory function at frequencies higher than conventionally tested in patients receiving cis-platinum.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |
7/9. erythromycin ototoxicity and acute psychotic reaction in cancer patients with hepatic dysfunction.Two cases of severe hearing loss due to intravenous administration of erythromycin lactobionate are described. Documented, bilateral sensorineuronal hearing loss developed in both patients and gradually improved when the dose of erythromycin was decreased. Neither patient had severe renal dysfunction (documented clearances of 25 to 30 mL/min), but both had hepatic dysfunction with elevated bilirubin levels. Additionally, both were receiving other ototoxic drugs concurrently. Both patients also had an acute psychotic reaction that was temporally related to the ototoxicity and high-dose erythromycin therapy.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |
8/9. hearing loss in pediatric renal patients.Modern techniques of prolonging life and useful function for endstage renal patients have been accompanied by a variety of new clinical and pathological manifestations, among which are inner ear problems. Of 151 pediatric renal patients followed prospectively 47% had hearing loss, which closely approximates that found in renal patients of all ages. However, only 5.3% of pediatric-age patients, as compared with 15% of all age groups, have hearing loss of unknown etiology. Certain types of hearing loss, for example, those due to acoustic trauma and Meniere's, were not found in the pediatric-age group, while ototoxic, congenital and genetic hearing losses were more common in young persons than in the overall group. Management includes assessment of hearing and vestibular function prior to and at intervals during the administration of ototoxics, monitoring of blood levels, careful attention to otological symptoms and observing the principles of hearing conservation.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |
9/9. chloramphenicol ototoxicity. A case report.A case of bilateral profound sensori-neural hearing loss following systemic administration of chloramphenicol is reported because of its rarity. The hearing loss was gradually progressive, involving one ear; and with a repeat course of the drug, the other ear too was involved. An idiosyncratic or allergic response to previous exposure to the drug may be the cause of the toxicity. One should be careful in prescribing the drug repeatedly; when this is done, the patient must be carefully observed for possible toxic effects.- - - - - - - - - - ranking = 0.5keywords = administration (Clic here for more details about this article) |