11/30. Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection.An encephalitic illness with a fatal outcome occurred in a 9 month old girl with virologically confirmed exanthem subitum. Human herpes-virus-6 (HHV-6) dna was found in the cerebrospinal fluid at the acute stage of the disease by the polymerase chain reaction, but the virus antigen was not detected in her brain tissue. This suggests that HHV-6-induced encephalitis/encephalopathy may be due to a non-infectious process.- - - - - - - - - - ranking = 1keywords = herpesvirus (Clic here for more details about this article) |
12/30. Roseola infantum in pregnancy. A case report.Roseola infantum (exanthem subitum) was first described as a specific syndrome by Zahorsky in 1913. It is a benign disease that occurs almost exclusively in infants and young children (six months to three years of age). We report a case of roseola in a pregnant woman. We were unable to find any prior reports of roseola in pregnancy. The classic presentation of roseola is characterized by high temperatures (103-105 degrees F) that last 3-5 days and resolve by crisis followed by the appearance of a morbilliform rash that lasts a few hours to a few days. The infectious agent is human herpesvirus-6. We recommend the addition of roseola to the differential diagnosis of rashes that occur in pregnancy. The potential danger to the fetus from this virus is unknown.- - - - - - - - - - ranking = 0.25keywords = herpesvirus (Clic here for more details about this article) |
13/30. facial nerve palsy after human herpesvirus 6 infection.facial nerve palsy has long been considered to have an infectious etiology, either viruses, mainly herpesviruses, or bacteria, such as borrelia burgdorferi. We report for the first time the association of human herpesvirus 6 and facial palsy in a previously healthy 1-year 9-month-old boy who developed left facial nerve palsy 7 days after exanthema subitum caused by human herpesvirus 6.- - - - - - - - - - ranking = 1.75keywords = herpesvirus (Clic here for more details about this article) |
14/30. Atypical clinical features of a human herpesvirus-6 infection in a neonate.A case of neonatal human herpesvirus 6 (HHV-6) B infection is presented. Although HHV-6 B was isolated from peripheral blood at the onset of the illness, a significant increase in viral antibody titers was not observed. The patient had a slight fever with generalized maculopapular skin rash and an increased number of atypical lymphocytes, which is quite different from the typical clinical features of exanthem subitum.- - - - - - - - - - ranking = 1.25keywords = herpesvirus (Clic here for more details about this article) |
15/30. Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia.This is a case study of a child who developed roseola infantum first, then varicella, and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV-6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV-6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies.- - - - - - - - - - ranking = 1.25keywords = herpesvirus (Clic here for more details about this article) |
16/30. Drug-induced hypersensitivity syndrome associated with human herpesvirus 6 and cytomegalovirus reactivation.We describe a patient with drug-induced hypersensitivity syndrome (DIHS) associated with human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) infection induced by sulfasalazine. Two weeks after starting sulfasalazine to treat a rectal ulcer, the patient developed disseminated macular erythema accompanied by fever, liver injury, and lymphadenopathy. Seroconversion of antibodies to HHV-6 was observed. Systemic steroid treatment was not effective against the eruptions. Five months after the onset, he presented with an acute febrile disease. The detection of CMV antigen on peripheral blood leukocytes and positive staining for CMV on cutaneous endothelium indicated active CMV infection. Furthermore, he developed a bacteremia of methicillin resistant staphylococcus aureus. An association the CMV reactivation with DIHS was suggested, although there remains the possibility that the systemic steroid treatment precipitated CMV reactivation. Recently, HHV-6 has been documented to have immunomodulating effects and to be associated with CMV reactivation. Therefore, we should pay attention to the possibility of CMV reactivation in patients with DIHS in whom the immunomodulating virus of HHV-6 has been reactivated.- - - - - - - - - - ranking = 1.25keywords = herpesvirus (Clic here for more details about this article) |
17/30. meningitis caused by human herpesvirus-6.Since the discovery of human herpesvirus-6 (HHV-6) the illnesses associated with it have increased steadily. Two infants with meningitis are reported: both suffered a mild meningitis and serological studies confirmed an acute HHV-6 infection. This report supports a role of HHV-6 in nervous system disease.- - - - - - - - - - ranking = 1.25keywords = herpesvirus (Clic here for more details about this article) |
18/30. Central retinal vein occlusion caused by human herpesvirus 6.We describe a 1-year-old girl with central retinal vein occlusion caused by human herpesvirus 6. She received systemic corticosteroid therapy. Although there was retinal recovery after the therapy, the visual acuity in her left eye still could not be measured.- - - - - - - - - - ranking = 1.25keywords = herpesvirus (Clic here for more details about this article) |
19/30. Roseola infantum caused by human herpesvirus-6: report of 7 cases with emphasis on complications.Roseola infantum is not an uncommon disease in children. The etiology was not known until 1988 when Yamanishi et al in japan first demonstrated that human herpesvirus-6 (HHV-6) was the causative agent. In the fall of 1989, we began to study the role of HHV-6 in roseola infantum in taiwan. A total of 7 cases of suspected roseola infantum were studied and all were proven to have primary HHV-6 infections. Six were classic cases of roseola infantum, while one had only fever without the rash. Two cases developed complications; one had leukopenia and thrombocytopenia and the other had aseptic meningitis and mononucleosis. This is the first report to substantiate that HHV-6 is an important cause of roseola infantum in taiwan, and that the virus could cause meningitis and thrombocytopenia.- - - - - - - - - - ranking = 1.25keywords = herpesvirus (Clic here for more details about this article) |
20/30. Meningo-encephalitis associated with HHV-6 related exanthem subitum.We report a 10-month-old boy with acute meningo-encephalitis associated with exanthem subitum. It has recently been reported that human herpesvirus-6 is the causative agent of exanthem subitum, and to our knowledge our case is the first report of meningo-encephalitis associated with HHV-6 infection.- - - - - - - - - - ranking = 0.25keywords = herpesvirus (Clic here for more details about this article) |
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