1/7. Autoimmune disease-associated lymphadenopathy from dermatomyositis. A case report.A case of autoimmune disease-associated lymphadenopathy (ADAL) in the lymph nodes linked to well documented dermatomyositis is presented. A 49-year-old Japanese woman was affected by a left axillary and a left inguinal lymphadenopathy at the onset of disease. A biopsy specimen taken from a left inguinal lymph node showed distortion of the nodal architecture and polymorphous lymphoid infiltration containing many plasma cells and plasmacytoid cells with scattered transformed lymphocytes, as well as a large number of capillaries. The polytypic nature of b-lymphocytes was demonstrated by immunohistochemistry and polymerase chain reaction. Epstein-Barr virus-associated lymphoplasmacytic infiltrates may occur in patients immunosuppressed by methotrexate administered for the treatment of dermatomyositis. However, Epstein-Barr virus-encoded small rna-positive cells were not identified by in situ hybridization. Moreover, the patient had no history of methotrexate therapy.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/7. milk of calcium fluid collection in dermatomyositis: ultrasound findings.Extensive subcutaneous and intermuscular calcium laden fluid collections (milk of calcium) were found in two young girls with severe dermatomyositis. Sonographic examination clearly showed the nature and extent of the collections. knowledge of this new feature of dermatomyositis should help avoid confusing these fluid collections with soft tissue infection and deep abscess in these often steroid dependent children.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/7. dermatomyositis associated with chronic myelogenous leukemia.dermatomyositis and polymyositis have been well established in association with malignant neoplastic disease. Most commonly, this association has been noted in patients with solid tumors rather than in patients with neoplasms of hematopoietic origin. We describe here a patient with chronic myelogenous leukemia who developed typical dermatomyositis, which responded to therapy with corticosteroids. This concurrence has been reported in only one previous patient to our knowledge. The nature and implications of the association of dermatomyositis and neoplasia are discussed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/7. myocardial infarction in dermatomyositis.A case of dermatomyositis manifesting electrocardiographic and vectorcardiographic changes compatible with an inferior and anterolateral wall myocardial infarction is presented herein. The nonocclusive nature of the heart muscle damage is evidenced by perfectly normal coronary artery angiography. We believe that this is the first reported case of a myocardial infarction pattern apparently due to dermatomyositis.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/7. dermatomyositis and coexistent ovarian cancer: a review of the compounding clinical problems.Although the nature of the relationship of dermatomyositis and malignancy is debated, the clinical implications of their coexistence is considerable. This review details the clinical and laboratory diagnostic features of the dermatomyositis (DM). Two case reports serve to focus on the unique management problems faced by the gynecologic oncologist when DM is associated with ovarian malignancy. Cricopharyngeal achalasia, an unusual aberration of DM, complicated the course of both patients.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/7. adult polyomyositis/dermatomyositis associated with acute myeloid leukemia. A case report.Reports of PM/DM associated with haematologic disorders are rare. We describe a 62-year-old man suffering from PM/DM who developed acute myeloid leukemia. The possible paraneoplastic nature of PM/DM in this patient is discussed.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/7. Tubular cytoplasmic inclusions in a case of childhood dermatomyositis with migratory subcutaneous nodules.A boy with dermatomyositis which began at the age of one year and five months showed multiple migratory subcutaneous nodules, which have seldom been described. Histological and electron microscopic studies of muscles and subcutaneous nodules demonstrated the following interesting findings. 1. light microscopy. The migratory subcutaneous nodules consisted of non-suppurative panniculitis and ischaemic adipo-necrosis as a sequel to vascular lesions. This finding suggests that the nodules may have arisen from the subcutaneous adipose tissue which had been severely damaged by systemic angiopathy. 2. Electron microscopy. Examination of the vessels in muscle and subcutaneous nodules showed tubular cytoplasmic inclusions with a diameter of approximately 250 A in the endoplasmic reticulum of vascular endothelial cells. These observations provide strong support for the concept that the fundamental pathologic process in childhood dermatomyositis is of a vascular nature, and the primary lesion is in the walls of the intramuscular blood vessels.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |