1/68. Cardiac myxoma with glandular component: case report and review of the literature.A 7 cm diameter tumor of the left atrium is reported in a 78 year-old woman with a past history of pT3N1M0 colonic adenocarcinoma. The histological examination of the atrial tumor disclosed areas of highly vascularized myxoid stroma with cells strongly reactive for vimentin. Multiple mucoid spaces lined by a single layer of goblet cells were scattered among those typical areas of myxoma. No nuclear atypia was observed. cytoplasm of the glandular cells was immunoreactive for epithelial antisera (keratin, EMA), CEA and CA19.9. Two years later, the patient was doing well, with no local recurrence of the cardiac myxoma and no secondary location of the colonic adenocarcinoma. The histological characteristics, the absence of atypia, the absence of tumoral extension or neoplastic lymphatic vascular thrombi in the pedicle or in the interatrial septum, and the finding of typical myxomatous areas supported the diagnosis of cardiac myxoma with glandular component. To our knowledge, 21 cases of myxoma with glandular mucinous component, focal or prominent, have been previously published in the literature. These myxoma were generally sporadic cases with the same clinical features and prognosis as typical myxoma. Immunoreactivity of these glandular structures was constant for epithelial markers. The positive immunostaining by CEA, and by CA19.9 in our case, reflects the histogenetic endodermal origin.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/68. Sigmoid colon cancer associated with primary hyperparathyroidism: report of a case.We present herein a case of sigmoid colon cancer associated with primary hyperparathyroidism (PHP). PHP is known to be associated with malignancy, and decreased intracolonic calcium (Ca) resulting from increased vitamin d (VD) levels may play a role in colorectal carcinogenesis. PHP was diagnosed in this patient by preoperative screening blood chemistry examination. The blood level of intact parathyroid hormone (PTH) was elevated and a parathyroid gland scintigram demonstrated abnormal uptake near the right lower lobe of the thyroid. There was no evidence of bone metastasis, and a sigmoid colectomy was performed with curative intent. The patient had an uneventful postoperative course without a critical elevation of the serum Ca level. This case report suggests that a relationship exists between PHP and colon cancer, and the possible mechanisms of this association are presented in our discussion.- - - - - - - - - - ranking = 0.125keywords = gland (Clic here for more details about this article) |
3/68. Colonic adenocarcinoma metastatic to the thyroid gland: a case report with immunohistochemical investigation.Clinically evident metastases of carcinomas to the thyroid gland are rare, particularly from a colorectal primary tumor. We present a case of colonic adenocarcinoma metastatic to the thyroid gland with histopathologic and immunohistochemical findings. A 68-year-old woman with a history of Dukes' stage B colon carcinoma presented a mass in the thyroid gland. The tumor was confirmed to be metastatic adenocarcinoma from the colon. The immunohistochemical findings demonstrated positive staining for cytokeratin 20, low-molecular-weight cytokeratin, villin and carcinoembryonic antigen, but stains were negative for cytokeratin 7 and thyroglobulin.- - - - - - - - - - ranking = 0.875keywords = gland (Clic here for more details about this article) |
4/68. Metastatic carcinoma in follicular adenoma of the thyroid gland.We report here two autopsy cases of carcinoma that metastasized to a thyroid follicular adenoma. The first was an 82-year-old man with sigmoid colon adenocarcinoma. Three years after a colectomy he died of multiple metastases. autopsy revealed that the metastatic colonic carcinoma was located in a thyroid follicular adenoma. The second case was a 51-year-old man with primary lung adenocarcinoma. At the time of admission, he was inoperable because of multiple organ metastasis. He died 14 months after admission due to the carcinoma. autopsy revealed a metastatic lung adenocarcinoma also located in a follicular adenoma, as in the first case. The phenomenon of tumor-to-tumor metastasis is rare. The mechanism is still unknown, and to our knowledge, only five cases of carcinoma metastatic to thyroid follicular adenoma have been documented in the literature.- - - - - - - - - - ranking = 0.5keywords = gland (Clic here for more details about this article) |
5/68. Colonic type adenocarcinoma of male urethra.A case of rare primary adenocarcinoma of the bulbomembranous portion of the male urethra is presented. The histological and immunohistochemical characteristics of this tumor are identical to those of colon adenocarcinomas. The pathogenesis can be explained either by neoplastic degeneration of globet cells found in the urethral epithelium or by malignant degeneration of persistent glandular elements that are embryonal residues. The patient was successfully treated with transurethral prostatectomy and with a high dose of radiation therapy.- - - - - - - - - - ranking = 0.125keywords = gland (Clic here for more details about this article) |
6/68. Multiple organ mucosa-associated lymphoid tissue lymphomas often involve the intestine.BACKGROUND: Low grade mucosa-associated lymphoid tissue (MALT) lymphomas usually are confined to single extranodal organs. Although some case reports have been published, clinicopathologic characteristics of multiorgan MALT lymphomas remain unclear. methods: The authors evaluated 7 MALT lymphoma cases involving multiorgans in the past 7 years. In this period, they experienced 304 cases of MALT lymphomas. They analyzed the clinicopathologic features of these cases, including examination of clonal comparison among the lesions. RESULTS: The patients, 4 females and 3 males, were aged 55-68 years old (average, 60.1 years). Four cases showed multiple organ involvement at the initial diagnosis or after a short period. In the other three cases, primary foci were the stomach, thyroid gland, and ocular adnexa; after a rather long period (3 years or more), distant metastases were found. Although intestinal primary lymphomas are rather rare, six of the seven cases showed large intestinal involvement. Lymph node involvement was proven in only three cases. The patients were rather resistant to the various therapeutic approaches. Although six patients are alive, five are with disease. dna analyses revealed that in five of the cases evaluated, identical clones were detected among the different affected organs. CONCLUSIONS: Multiorgan MALT lymphomas are rather rare. Most cases probably derived from a single clone, and lymphoma cells may selectively move among MALTs via a homing system with preferential involvement of the colon. Because multiorgan MALT lymphomas rarely achieve complete remission by treatment with combination chemotherapy or irradiation, MALT lymphomatous lesions should be checked carefully, especially in the large intestine.- - - - - - - - - - ranking = 0.125keywords = gland (Clic here for more details about this article) |
7/68. Primary low-grade B cell non-Hodgkin's lymphoma of MALT type simultaneously arising in the colon and in the lung: report of a case.zone B cell lymphoma of mucosa-associated lymphoid tissue type according to the Revised European American lymphoma classification). Other mucosa-associated lymphoid tissue-type lymphomas arise in the salivary glands, thyroid gland, and in the lung (bronchus-associated lymphoid tissue). Here, we report the first case of a monoclonal mucosa-associated lymphoid tissue lymphoma with simultaneous manifestation in the colonic and bronchial mucosa in a 62-year-old patient. With mitoxantrone, chlorambucil, and prednisone polychemotherapy, a complete year-long remission was achieved.- - - - - - - - - - ranking = 0.25keywords = gland (Clic here for more details about this article) |
8/68. muir-torre syndrome.muir-torre syndrome is a rare autosomal dominant condition in which multiple primary malignancies occur together with a sebaceous gland tumour. Early recognition of the syndrome in patients with sebaceous gland tumours should facilitate early detection of subsequent malignancies if the patient with entered into appropriate screening programmes. A case occurring in scotland is described and implications for management, screening for members of the family are discussed.- - - - - - - - - - ranking = 0.25keywords = gland (Clic here for more details about this article) |
9/68. Presacral myelolipoma in a patient with colon carcinoma.myelolipoma is an uncommon benign tumor, composed of an admixture of adipose tissue and hematopoietic cells, usually discovered within the adrenal glands. Extra-adrenal myelolipomas are rare and approximately half of the reported cases were presacral. We report a case of an asymptomatic presacral myelolipoma measuring 9x8x7 cm, incidentally found in a 71-year-old woman with a stenosing colon cancer. ultrasonography, computed tomography and magnetic resonance imaging of the presacral mass evidenced a well circumscribed tumor with heterogeneous features due to a nonuniform composition. Surgical excision of the mass was performed.- - - - - - - - - - ranking = 0.125keywords = gland (Clic here for more details about this article) |
10/68. Colonic adenocarcinoma metastatic to thyroid Hurthle cell carcinoma presenting with airway obstruction.Clinical presentation of a metastatic carcinoma to the thyroid gland is rare; it is more commonly reported in autopsy studies. Clinical presentation of malignant primary tumors to the thyroid is most common for renal, breast, and lung tumors that metastasize through a blood-borne route to the vascular thyroid gland. A 71-year-old man with a history of colon cancer that had been in remission for seven years had a long-standing thyroid goiter being followed elsewhere, with previous needle aspiration cytology consistent with a benign thyroid goiter. He presented with stridor, a 14 cm thyroid mass, and a larynx dramatically deviated to the contralateral side. thyroidectomy resulted in return of the larynx to the midline with mobile vocal cords. Final pathologic examination indicated the rare phenomenon of tumor-to-tumor metastasis--a colon adenocarcinoma metastatic to a thyroid Hurthle cell carcinoma with focal areas of dedifferentiated anaplastic thyroid cancer. Colorectal carcinoma can remain asymptomatic for years. A thyroid mass in a patient previously diagnosed with a slow-growing malignancy (breast, kidney, colon) should be suspected of being a distant metastasis. Surgery may be indicated as palliative treatment.- - - - - - - - - - ranking = 0.25keywords = gland (Clic here for more details about this article) |
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