1/6. A case of lithium intoxication with downbeat vertical nystagmus.lithium carbonate has recently been used in the treatment of manic diseases. However, since the marginal range between therapeutic and toxic doses is very narrow, close attention should be paid to the development of adverse reactions in its application. Lithium intoxication is manifested by neurological symptoms. Neurotological tests were performed on a patient with lithium intoxication that occurred in the course of psychiatric treatment of mania. The observed sequelae included marked downbeat vertical nystagmus and truncal ataxia. The main lesions in the present case were considered to be located in the cerebellum. Close observation, including neurotological tests, is of greatest importance because in cases of lithium intoxication the development of cerebellar as well as brainstem disorders must not be overlooked.- - - - - - - - - - ranking = 1keywords = intoxication (Clic here for more details about this article) |
2/6. CT findings following diphenylhydantoin intoxication.CT findings in three female epileptic patients are presented. The patients were treated with toxic doses of the anticonvulsant diphenylhydantoin, leading to irreversible ataxia of varying severity. CT shows cerebellar atrophy, including discernible sulci, a dilated 4th ventricle, basal cisterns, and subarachnoid space. These effects of severe DPH toxicity are relevant in the differential diagnosis of 'idiopathic' and other toxic and systemic atrophies, as well as dysontogenetic lesions of the cerebellum.- - - - - - - - - - ranking = 0.57142857142857keywords = intoxication (Clic here for more details about this article) |
3/6. Cerebellar atrophy following phenytoin intoxication.Cerebellar degeneration has been demonstrated in several patients receiving phenytoin therapy. In most cases it has been unclear, however, whether the degeneration was caused by the drug per se or by other mechanisms known to lead to cerebellar damage. We describe a patient who developed a marked cerebellar atrophy, demonstrated on computed tomographic scan, following an episode of acute, severe phenytoin intoxication. The patient received phenytoin prophylactically for 2 1/2 months after an uncomplicated subarachnoid hemorrhage and was in good health when the treatment was started. He has never had seizures, and no other possible cause of chronic cerebellar changes is known. The initially severe clinical signs of cerebellar dysfunction have subsided slowly. We conclude that phenytoin can directly cause cerebellar degeneration.- - - - - - - - - - ranking = 0.71428571428571keywords = intoxication (Clic here for more details about this article) |
4/6. Periodic alternating nystagmus in phenytoin intoxication.A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication. The nystagmus resolved as the serum phenytoin level fell, as demonstrated by electronystagmography. Periodic alternating nystagmus generally implies structural brainstem disease, especially at the craniocervical junction. To our knowledge, its drug-related occurrence has not been previously reported.- - - - - - - - - - ranking = 0.71428571428571keywords = intoxication (Clic here for more details about this article) |
5/6. Computed tomography demonstration of brain damage due to acute sodium monofluoroacetate poisoning.The case reported developed an acute brain syndrome, including cerebellar signs, shortly after the ingestion of sodium monofluoroacetate. After insiduous improvement of the clinical symptoms, the patient remained with an "end-stage" cerebellar ataxia for 18 months following the acute intoxication. The development of brain atrophy, proven by computed tomography, is considered to represent a direct influence of sodium monofluoroacetate on the brain and to reflect the unique disturbances in cellular metabolism of glucose.- - - - - - - - - - ranking = 0.14285714285714keywords = intoxication (Clic here for more details about this article) |
6/6. Chronic bromvalerylurea intoxication: dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse.Nalon-Ace and other nonsteroidal anti-inflammatory drugs (NSAID) containing bromvalerylurea (BVU) are sold as over-the-counter (OTC) drugs and are obtainable without prescription in japan. A 32-year-old woman was diagnosed as having chronic BVU intoxication due to habitual use of Nalon-Ace. In addition to cerebellar ataxia and pyramidal signs well known in this condition, she showed an as yet non-described dystonic posture of the neck. Laboratory tests revealed an elevated concentration of serum organic bromide, iron deficiency anemia, and hyperchloremia. brain magnetic resonance imaging (MRI) revealed definite cerebellar atrophy. We should consider the possibility of chronic BVU intoxication in peculiar neurological cases like ours.- - - - - - - - - - ranking = 0.85714285714286keywords = intoxication (Clic here for more details about this article) |