1/122. A case of pediatric Behcet's disease with intestinal involvement.We report a 6-year-old girl with recurrent oral aphthae, genital and perianal ulcers, and folliculitis-like erythema followed by intestinal symptoms. No ocular lesions were found. Her ailment was diagnosed as incomplete Behcet's disease with intestinal involvement. According to the literature, pediatric Behcet's disease is characterized by a low incidence of ocular lesions and a high incidence of intestinal involvement, as exhibited in this case. As intestinal lesions in pediatric Behcet's disease are often life-threatening, a barium enema must be given to exclude the possibility of intestinal involvement when pediatric patients with Behcet's disease complain of abdominal pain.- - - - - - - - - - ranking = 1keywords = ocular (Clic here for more details about this article) |
2/122. Neuro-Behcet's disease presenting with isolated unilateral lateral rectus muscle palsy.The authors present the clinical findings of a 30-year-old female and a 29-year-old male who both had isolated unilateral lateral rectus muscle palsy in neuro-Behcet's disease. The clinical feature related to isolated abduscens nerve palsy was identified by CT, systemic assessment and extraocular examination. These patients' constellation of findings appear to be unique: it does not follow any previously reported pattern of ocular manifestations of neuro-Behcet's disease.- - - - - - - - - - ranking = 1keywords = ocular (Clic here for more details about this article) |
3/122. Demyelination of retinal myelinated nerve fibers in Behcet's disease.A 39 year-old Behcet's patient had demyelination of retinal myelinated nerve fibers after recurrent papillitis and vitritis. Oral prednisolone, cyclosporine, and later periocular corticosteroids and oral colchicine were used but demyelination continued over a 5 year-period. A pseudobulbar palsy with urinary incontinence and pyramidal tract signs developed and azathioprine and corticosteroids were used. Demyelination of retinal nerve fibers stopped and while treatment was underway, the central nervous system (CNS) signs were stable. While the ocular pathology of Behcet's can mirror the CNS signs, indeed optic nerve ischemic demyelination may signal the potential for CNS involvement; azathioprine with prednisone may be more effective in the long-term for optic nerve and CNS involvement than cyclosporine with prednisone.- - - - - - - - - - ranking = 1keywords = ocular (Clic here for more details about this article) |
4/122. A bad eye and a sore lip.A 48-year-old woman developed painful visual loss in the left eye, meningismus, and painful oral ulcers. magnetic resonance imaging of the brain with gadolinium demonstrated enhancement of the left optic nerve. Lumbar puncture showed a lymphocytic pleocytosis, and a biopsy specimen of one of the oral ulcerations was consistent with Behcet's disease. epidemiologic factors and diagnostic criteria for Behcet's disease are discussed.- - - - - - - - - - ranking = 0.018341096624938keywords = eye (Clic here for more details about this article) |
5/122. Retinal tears associated with panuveitis and Behcet's disease.To report retinal tears formation in 3 eyes of 2 patients with active panuveitis and Behcet's disease. We describe 2 patients that were diagnosed and treated for Behcet's disease with active panuveitis. Retinal tears developed while the inflammation was active. The patients were treated with topical, oral steroids, and cyclosporine therapy for bilateral panuveitis. One patient presented with a retinal tear located at the periphery of the active retinal lesion. The other had multiple tears associated with active retinal lesions in both eyes. argon laser photocoagulation was performed in both patients as soon as the tears were detected. Ocular inflammation was controlled with this therapy, and only a few mild flare-ups occurred. The patients have been followed up for 8 and 16 months, respectively. During this period no new retinal tears have developed. Although retinal tear formation is rarely associated with Behcet's panuveitis, the clinician should be aware of this as a possible complication. When structural changes are present in the vitreous, detailed ophthalmoscopy is indicated to assess for retinal tears. If a tear is detected in a patient with panuveitis and Behcet's disease, laser photocoagulation therapy should be performed immediately to prevent retinal detachment.- - - - - - - - - - ranking = 0.0073364386499751keywords = eye (Clic here for more details about this article) |
6/122. Recurrent oral and oculogenital ulcerations (Behcet's syndrome).The literature on Behcet's syndrome is reviewed and four cases are presented. Two of the patients were men and two were women. The age at presentation varied from 21 to 55 years. All patients had the first manifestations of the disease before the age of 25 and two before the age of 10. None presented with the complete triad of symptoms. All four had oral ulceration and either ocular lesions (two cases) or lesions on the genitals (two cases). According to the present theories, the diagnosis of Behcet's syndrome is established by the presence of any two of the triad of symptoms. We suggest that in order to be classified as having Behcet's syndrome, a patient should have oral lesions and either genital and/or ocular ulcerations.- - - - - - - - - - ranking = 1keywords = ocular (Clic here for more details about this article) |
7/122. A case of coexisting Behcet's disease and ankylosing spondylitis.Behcet's disease (BD) is a chronic inflammatory condition involving several organs, such as skin, mucous membrane, eye, joint, intestine, lung and central nervous system. Ankylosing spondylitis (AS) is a prototype of seronegative spondyloarthropathy, and a chronic systemic inflammatory disorder of the axial skeleton, mainly affecting the sacroiliac joint and spine. In the latter, systemic complications may develop in addition to joint involvement. The coexistence of BD and AS has been rarely reported in the literature. The inclusion of BD among seronegative spondyloarthritides and whether sacroiliitis (SI) develops in BD are still being debated. We describe a 28-year-old man who has fulfilled the diagnostic criteria for BD and AS as well.- - - - - - - - - - ranking = 0.0036682193249875keywords = eye (Clic here for more details about this article) |
8/122. Beneficial effects of interferon-alpha in a case with Behcet's disease.At the age of 20 years, a Japanese man with recurrent oral aphthae, genital ulcers, folliculitis, erythema nodosum, episodic arthritis and epididymitis was diagnosed as having Behcet's disease (BD) in 1966. He has had active ocular manifestations of BD since 1990. These symptoms recurred and never abated for a long period of time. A right renal cell carcinoma developed and he underwent right nephrectomy in April 1996. Treatment with interferon-alpha was started from June 1996 as supplemental chemotherapy. No active phase developed during administration of IFN-alpha. We suggest that IFN-alpha may play a role as an immunomodulatory agent in BD.- - - - - - - - - - ranking = 0.5keywords = ocular (Clic here for more details about this article) |
9/122. Preseptal abscess formation following ocular cryotherapy for Behcet's uveitis.A 42-year-old man with Behcet's disease developed a rapidly growing mass under his right lower eyelid a week after transconjunctival cryotherapy. He underwent surgical drainage of the mass following imaging studies. magnetic resonance imaging scans demonstrated the abscess, which did not violate the orbital septum. Cultures from drained material yielded staphylococcus aureus. He recovered completely with systemic antibiotics. Preseptal abscess may occur as a complication of intense transconjunctival cryotherapy for intraocular disorders, and patients should be followed closely within the first few weeks postoperatively.- - - - - - - - - - ranking = 2.503668219325keywords = ocular, eye (Clic here for more details about this article) |
10/122. Clonally accumulating T cells in the anterior chamber of Behcet disease.PURPOSE: To clarify the nature of infiltrating T cells into the anterior chamber of a patient with Behcet disease. methods: aqueous humor was obtained from a patient with ocular Behcet disease by paracentesis. rna isolated from the cells in aqueous humor was reverse transcribed into complementary dna. Complementary dna encoding the variable (V) diversity (D) joining (J) (junctional) region of T-cell receptor beta chain V domain (TCR BV) chain was amplified by T-cell receptor BV family polymerase chain reaction. RESULTS: polymerase chain reaction Southern blot analysis showed that T-cell receptor BV3, BV5, and BV7 were dominantly expressed on ocular T cells of this patient. In addition, dna sequencing revealed that monoclonal or oligoclonal T-cell accumulation was found in T-cell receptor BV3( ), BV5( ), and BV7( ) T cells. CONCLUSION: These findings suggest that some T cells infiltrating into the anterior chamber of a patient with ocular Behcet disease expand by antigen-driven stimulation, indicating the pivotal role of T cells in the pathogenesis of ocular Behcet disease.- - - - - - - - - - ranking = 2keywords = ocular (Clic here for more details about this article) |
| | Next -> |