1/11. Arthodesis of the infected ankle and subtalar joint.arthrodesis of the ankle or subtalar joint for limb salvage in joint sepsis is extremely complicated, and produces a protracted course of management. A successful outcome is founded on the diligence of the surgeon in the preoperative evaluation, intraoperative technique, and postoperative care of the patient. Liberal consultation with infectious disease specialists, vascular, and plastic surgeons is recommended. Recognition of patient-specific comorbidities is essential to the selection of appropriate limb salvage candidates.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
2/11. Candidal prosthetic hip infection in a patient with previous candidal septic arthritis.We describe the case of a patient with chronic monocytic leukemia who underwent total hip arthroplasty (THA) for hip arthrosis. The patient has a history of candida albicans arthritis of the same joint 5 months before THA surgery. Seven months after the prosthetic joint surgery, the patient developed a C albicans prosthetic infection that was successfully treated with amphotericin b and prosthesis removal. At surgery, the patient was believed cured of the candidal infection. risk of infection after prosthetic joint surgery in patients with previous fungal joint infections has not been fully investigated. A lengthy infection-free follow-up period is probably necessary but may not be sufficient to prevent the occurrence of postoperative infections in these patients.- - - - - - - - - - ranking = 5keywords = candida (Clic here for more details about this article) |
3/11. Candida arthritis: cellular immune responses of synovial fluid and peripheral blood lymphocytes to candida albicans.A case of septic candida albicans arthritis of the knee in a patient with systemic candidiasis is presented. Systemic and intra-articular cellular immune responses to C albicans and various bacterial antigens were monitored for 15 weeks. It is shown that the candida induced blastogenesis of synovial fluid lymphocytes was much more stimulated than that of peripheral blood lymphocytes, and that the proportion of activated cells expressing HLA class II antigens was markedly increased in the synovial fluid. Strong cellular immune responses to candida albicans could still be shown many weeks after the synovial fluid aspirates had become sterile. For the first time synovial fluid derived, CD4 positive T lymphocyte clones with specificity for candida antigens were characterised and further propagated in vitro.- - - - - - - - - - ranking = 2keywords = candida (Clic here for more details about this article) |
4/11. Candida septic arthritis in rheumatoid arthritis.We describe a patient with a 10-year history of rheumatoid arthritis who developed septic arthritis of the knee secondary to candida albicans. Joint sterilization was obtained by debridement and 865 mg. of IV amphotericin b. We review 23 other cases of candidal arthritis in adults with specific reference to disease recognition and treatment.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
5/11. Candidal pyarthrosis in an AIDS patient.The unusual occurrence of a case of indolent candida albicans pyarthrosis arising as a late complication in a 57-year-old male patient with AIDS, despite prior treatment with amphotericin b for candidemia, is reported. The case is discussed in the context of candidal pyarthrosis and of the rarely reported other fungal arthridites in AIDS patients.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
6/11. Clostridial septic arthritis: case report and review of the literature.We describe a patient who had septic arthritis caused by clostridium perfringens. Clostridial organisms are very uncommon causes of septic arthritis. Only 13 cases have been reported previously. The diagnosis should be suspected in patients with a history of penetrating joint trauma and in immunocompromised patients. Successful treatment has usually consisted of surgical synovectomy in combination with high-dose intravenous penicillin therapy. Multiple aspirations of affected joints as a definitive treatment should be used with caution and only in patients who are not candidates for surgery.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
7/11. Neonatal and infantile candidal arthritis with or without osteomyelitis: a clinical and radiographical review of 21 cases.Four cases of candidal arthritis and osteomyelitis are presented and 17 others are reviewed from the literature. The clinical and radiographic aspects of the entity are discussed in detail and compared with those of bacterial septic arthritis. The role of predisposing factors are elaborated. An increase in the incidence of the disease is anticipated and the diagnostic difficulties are enumerated.- - - - - - - - - - ranking = 5keywords = candida (Clic here for more details about this article) |
8/11. Assessment of antifungal therapy in an 800-gram infant with candidal arthritis and osteomyelitis.A 720-g premature newborn developed disseminated candidiasis during treatment with systemic antibiotics and total parenteral nutrition through an umbilical arterial catheter. Clinical features were typical for candidal skeletal infection at this age and included warmth and fusiform swelling of the lower extremities together with radiographic evidence of osteolysis and cortical bone erosion. candida albicans was cultured from blood, urine, joint fluid, and a bone aspirate. The infection was cured with a 44-day course of amphotericin b and flucytosine (5-fluorocytosine). Antifungal therapy was monitored closely with serum drug levels and laboratory tests for bone marrow toxicity and renal dysfunction. serum levels of both drugs were comparable to those achieved in older patients treated with similar doses. Significant concentrations of amphotericin b were detected in serum four and 17 days after completion of therapy, indicating a slow rate of elimination similar to that which occurs in adults. There was no evidence of drug-induced toxicity other than transient elevation in the fractional urinary excretion of sodium. This suggests that antifungal therapy may be effectively and safely administered to infants in dose schedules similar to those used for older patients.- - - - - - - - - - ranking = 5keywords = candida (Clic here for more details about this article) |
9/11. Erosive candida arthritis in a patient with disseminated candidiasis.Candida arthritis of the knee joint of 9 months' duration is described in a leukemic patient. Examination of the joint at autopsy revealed no signs of osteomyelitis, despite the chronicity of the arthritic process, and only minimal fungal invasion of the cartilage in a eroded area.- - - - - - - - - - ranking = 4keywords = candida (Clic here for more details about this article) |
10/11. candida albicans arthritis one year after successful treatment of fungemia in a healthy infant.Fungal arthritis in pediatric patients is rare and is most often associated with hematogenous spread to the affected joint. It is generally seen concomitant with, or shortly after, fungemia. We report a case of an immunocompetent patient in whom candidal arthritis developed 1 year after initial fungemia. The initial candidiasis was considered to be adequately treated with amphotericin b. The Candida isolates from the neonatal fungemia and subsequent arthritis were the some as identified by electrophoretic karyotype, restriction fragment length polymorphism analysis, and antifungal susceptibility testing. Pediatric candidal fungemia, arthritis, and their treatments are discussed.- - - - - - - - - - ranking = 2keywords = candida (Clic here for more details about this article) |
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