A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous dna pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for rna binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (oncogene proteins, fusion) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (liposarcoma, myxoid) and acute myeloid leukemia.