1/11. Intracranial haemorrhage due to vitamin k deficiency following gastroenteritis in an infant.Breastfed infants who are not given supplemental vitamin K after birth may develop vitamin k deficiency following gastroenteritis. Severe intracranial haemorrhage may occur.- - - - - - - - - - ranking = 1keywords = haemorrhage (Clic here for more details about this article) |
2/11. cerebral hemorrhage associated with vitamin k deficiency in congenital tuberculosis treated with isoniazid and rifampin.We report a male infant with congenital tuberculosis who developed cerebral hemorrhage associated with vitamin k deficiency during treatment with isoniazid and rifampin. Despite an absence of risk factors for vitamin k deficiency, the severe hemorrhagic disorder occurred at 4 months of age. We speculate that vitamin k deficiency in the present case may have resulted from a synergic effect of antituberculosis agents and immaturity of vitamin K metabolism and/or its absorption.- - - - - - - - - - ranking = 0.0021146893136719keywords = cerebral (Clic here for more details about this article) |
3/11. vitamin k deficiency and bleeding after long-term use of cholestyramine.Although it has been long known that in theory the use of cholestyramine can cause coagulopathy due to reduced absorption of vitamin K, only a few cases have been reported. In those cases the coagulopathy occurred within a few weeks to months after the start of therapy. We report a patient with severe pruritus due to intrahepatic cholestasis, who was on cholestyramine therapy for over 25 years before haemorrhage occurred. This case demonstrates that one should be aware of the possibility of depletion of fat-soluble vitamins during the long-term use of cholestyramine.- - - - - - - - - - ranking = 0.2keywords = haemorrhage (Clic here for more details about this article) |
4/11. brain haemorrhage in five infants with coagulopathy.Most intracranial haemorrhages in infants after the neonatal period are secondary to non-accidental injury. Occasionally brain haemorrhages in non-mobile infants are due to an inherited coagulopathy. This may often be diagnosed with a coagulation screen on admission. Little is known about the neurological outcome of infants in the latter group. Five infants are described who presented with acute spontaneous brain haemorrhage secondary to an inherited coagulopathy (n = 3) and vitamin k deficiency in alpha(1) antitrypsin deficiency (n = 1) and Alagille's syndrome (n = 1). Despite the critical clinical presentation and the severe imaging findings, these five infants made a good neurological recovery. Infants presenting with spontaneous ICH due to a significant (inherited) coagulopathy are usually easy to differentiate from non-accidental shaking injury; their bleeding pattern within the brain seems different from non-accidental shaking injury and neurodevelopment outcome appears better.- - - - - - - - - - ranking = 1.4001169992716keywords = haemorrhage, brain (Clic here for more details about this article) |
5/11. Congenital vitamin K-dependent coagulation factor deficiency: a case report.Congenital vitamin K-dependent coagulation factor deficiency is a very rare bleeding disorder, which usually presents with episodes of intracerebral bleed in the first few weeks of life, sometimes leading to a fatal outcome. We report a case of combined factor deficiency of vitamin K-dependent factors in which the patient presented with both intracerebral bleeding, and possibly also thrombosis, and responded to a vitamin K supplement along with fresh frozen plasma.- - - - - - - - - - ranking = 0.045646064110515keywords = intracerebral, cerebral (Clic here for more details about this article) |
6/11. Central diabetes insipidus following intracranial hemorrhage due to vitamin k deficiency in a neonate.A previously healthy 30-day-old girl presented with seizures, irritability and inability to sleep for three days. Vitamin K was not given just after birth. She was lethargic. A multifocal clonic seizure was evident during examination. anisocoria was diagnosed on eye examination. brain magnetic resonance imaging showed intracerebral hemorrhage, ventricular dilatation, and hematoma in the left temporofrontal region extending to the hypothalamus. Central diabetes insipidus was diagnosed by water deprivation due to dehydration and hypernatremia, and then desmopressin was added to phenobarbital. The possible mechanism of central diabetes insipidus in our patient is damage of vasopressin pathway resulting from compression of hemorrhage. An operation of ventriculoperitoneal shunt was also performed due to hydrocephalus. While she was symptom-free except for neurological sequel during routine control examinations after discharging from hospital, the parents said that she died, most probably from bronchopneumonia, at the age of 7.5 months. In conclusion, we emphasize that prophylactic vitamin K should be administrated to all babies just after birth, and infants with intracranial hemorrhage should carefully be monitored for central diabetes insipidus.- - - - - - - - - - ranking = 0.022823032055258keywords = intracerebral, cerebral (Clic here for more details about this article) |
7/11. Acute infantile thrombocytosis and vitamin k deficiency associated with intracranial haemorrhage.A 5-week-old breast-fed girl presented unconscious and convulsing with heavily blood-stained CSF under increased pressure. This was associated with oozing from venepuncture sites, a grossly prolonged prothrombin time, and a raised platelet count. The prothrombin time became normal 18 hours after she had been given parenteral vitamin K and a transfusion of fresh plasma and red cells, but the thrombocytosis persisted. A moderate communicating hydrocephalus also remained and was treated, and one year later health and development appeared normal. The thrombocytosis resolved after a few weeks and has not recurred.- - - - - - - - - - ranking = 0.8keywords = haemorrhage (Clic here for more details about this article) |
8/11. vitamin k deficiency in newborns: a case report in alpha-1-antitrypsin deficiency and a review of factors predisposing to hemorrhage.A 4-week-old, breast-fed female infant appeared healthy until signs and symptoms of CNS deterioration suddenly occurred. At presentation the infant was found to have a left-sided parietal intracerebral hematoma, markedly prolonged prothrombin time, and partial thromboplastin time, normal platelet count, and jaundice with a total and direct serum bilirubin level of 5.4 mg/dL and 2.6 mg/dL, respectively. Vitamin K1 and fresh frozen plasma returned the prothrombin time and partial thromboplastin time to normal values within 18 hours, suggesting that the infant had severe vitamin k deficiency complicated by intracerebral hemorrhage. Evaluation of the infant's direct hyperbilirubinemia led to the diagnosis of homozygous (pi-type ZZ [PiZZ] ) alpha-1-antitrypsin deficiency. The clinical circumstances predisposing to vitamin k deficiency in newborns and infants are discussed. Based on our observations in this case, we suggest that cholestatic liver disease should be suspected when unexplained vitamin k deficiency occurs in early infancy. The role of vitamin K in hemostasis and the laboratory diagnosis of vitamin k deficiency are discussed as they apply to the evaluation of hemorrhage in newborns and infants.- - - - - - - - - - ranking = 0.045646064110515keywords = intracerebral, cerebral (Clic here for more details about this article) |
9/11. Fatal cerebellar haemorrhage due to phenprocoumon poisoning.A 32-year-old patient died of a cerebellar haemorrhage and the blood coagulation analysis before death suggested defective synthesis of vitamin K-dependent clotting factors due to vitamin k deficiency. The post-mortem toxicological examination of different tissues revealed phenprocoumon poisoning as the cause of death. The differential diagnosis of vitamin k deficiency and the toxicology of hydroxycoumarins are discussed.- - - - - - - - - - ranking = 1keywords = haemorrhage (Clic here for more details about this article) |
10/11. Intracerebral hemorrhage: a rare late manifestation of vitamin-K deficiency in a breastfed infant. A case report.Late hemorrhagic disease of the newborn (HDN) is a rare complication of vitamin-K deficiency and is especially associated with intracranial hemorrhage. It may also occur in infants who received vitamin-K prophylaxis at birth. Here, we reported a case of late HDN with frontal lobe hemorrhage due to vitamin-K deficiency. This form of intracranial hemorrhage of late HDN has been reported in the literature very rarely. We conclude that the efficiency of single-dose vitamin-K prophylaxis should be revaluated.- - - - - - - - - - ranking = 0.0084587572546876keywords = cerebral (Clic here for more details about this article) |
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