1/11. Cervical/vaginal endometriosis with atypia: A cytohistopathologic study.Neoplastic or atypical glandular epithelial cells of uncertain significance were reported in the preoperative smears from 10 women with cervical or vaginal endometriosis. Subsequent conization and vaginal biopsy revealed endometriotic tissue with variable epithelial atypia, but no evidence of in situ or invasive carcinoma. review of the smears revealed appearances similar to those seen in "high cervical sampling" or in smears from patients with tubal metaplasia. The presence of large cohesive cell sheets with retained cell polarity and well-defined cytoplasmic edges, of endometrial cell "whorls" and tubular structures, and of endometrial-like stromal cells coupled with the absence of three-dimensional cell clusters, peripheral cell-sheet crowding, "cell feathering," and pseudostratified cell strips are features helpful in the distinction between cervical/vaginal endometriosis and adenocarcinoma. Diagn. Cytopathol. 1999;21:188-193.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/11. The gonadotropin-releasing hormone agonist leuprolide acetate induces apoptosis and suppresses cell proliferative activity in rectovaginal endometriosis.A gonadotropin-releasing hormone agonist, leuprolide acetate, was administered every 4 weeks for treatment of rectovaginal endometriosis. Degrees of apoptosis (percentage of in situ deoxyribonucleic acid 3'-end-labeled cells) and cell proliferative activity (percentage of cells with immunostaining for proliferating cell protein Ki-67) were examined in endometriotic glands of biopsy specimens taken before and during gonadotropin-releasing hormone agonist therapy. gonadotropin-releasing hormone agonist induced apoptosis and suppressed cell proliferative activity in endometriotic glands.- - - - - - - - - - ranking = 2keywords = gland (Clic here for more details about this article) |
3/11. Symptomatic arteriovenous malformation of Bartholin's gland. A case report.BACKGROUND: arteriovenous malformations are composed of large, tortuous arteries and misshapen, veinlike structures. They are extremely uncommon in the genital tract. CASE: An arteriovenous malformation in a Bartholin gland presented as intermittent vaginal bleeding in a 43-year-old woman. CONCLUSION: Persistent unexplained bleeding from Bartholin's gland requires surgical excision.- - - - - - - - - - ranking = 6keywords = gland (Clic here for more details about this article) |
4/11. Prompt regression of cystic vaginal adenosis following cessation of oral contraceptive therapy.Cystic vaginal adenosis was diagnosed in a 31-year-old woman. This lesion regressed promptly following the cessation of an oral contraceptive (Ovulen-21) which had been used continuously for 5 years. The temporal relationship between discontinuation of contraceptive treatment and the regression strongly suggests that the medication played a causal role in producing cystic vaginal adenosis. A possible mechanism may have been the stimulation of quiescent glands to growth and cystic dilatation, which finally produced a lesion associated with clinical symptoms.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/11. recurrence of endometrial adenocarcinoma in a prior Bartholin's cyst marsupialization incision.BACKGROUND: Endometrial cancer recurrences in surgical incisions are rare and thought to be due to seeding of the area with microscopic disease at the time of original surgery. CASE: A 53-year-old woman underwent a dual procedure of a marsupialization of a benign bartholin's cyst with a hysteroscopic dilation and curettage for postmenopausal bleeding and received the diagnosis of endometrial adenocarcinoma. Final pathology from subsequent hysterectomy and staging procedure demonstrated a surgical Stage IB Grade 1 endometrial cancer. An isolated recurrence of disease in her marsupialization scar was discovered 10 months after her staging procedure. CONCLUSION: This case represents the only described endometrial cancer recurrence in a Bartholin's gland which was contaminated at the time of the original hysteroscopy and dilation and curettage.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
6/11. Unusual variants of vaginal adenosis: a challenge for diagnosis and treatment.Two unusual cases of vaginal adenosis in non-diethylstilbestrol (DES)-exposed patients are presented. These cases created an initial difficulty in histological classification and exclusion of the diagnosis of adenocarcinoma. The first case presented a problem of atypical columnar epithelium with simple gland architecture, while the second showed a pseudoinfiltrative pattern of small glands, but without cytological atypia. A diagnosis of glandular dysplasia (atypical columnar epithelium) was finally made in the first case and vaginal adenosis with unusual architectural features in the second. The first patient was treated by excision and the second expectantly. Subsquently, neither patient has developed carcinoma. The spectrum of glandular changes in vaginal adenosis appears analogous to that of the cervix. Until the natural history of sufficient numbers of these variants of vaginal adenosis have been studied, the analogous cervical condition may serve as a guide to prognosis. The diagnosis of invasive adenocarcinoma should be made cautiously unless there are both architectural and cytological features of malignancy.- - - - - - - - - - ranking = 4keywords = gland (Clic here for more details about this article) |
7/11. Hydrometrocolpos: diagnosis and follow-up by ultrasound--a case report.Hydrometrocolpos is accumulation of secretions in the vagina and uterus, caused by excessive intrauterine stimulation of the infant's cervical mucous glands by maternal oestrogen in the presence of an intact hymen (Wilson et al 1978). hydrocolpos is dilatation of the vagina proximal to a congenital obstruction. If the uterus is also dilated, the condition is called hydrometrocolpos. Most cases of hydrocolpos are associated with an imperforate hymen that forms a thin bulging membrane between the labia. Though many cases of hydrometrocolpos have been reported in literature, there is no case report which shows classical ultrasound findings and follow up ultrasound scans to show the involuted uterus. We are presenting a case report whose diagnosis was established on ultrasound. This case highlights the value of ultrasound in diagnosing this condition and excluding other associated renal anomalies.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
8/11. Skene's gland abscess with suburethral diverticulum in an adolescent.Suburethral diverticula have been reported to occur in 3-5% of adult females. They are rarely found in adolescents. We describe such a lesion that arose secondary to an abscess of Skene's glands in a 14-year-old sexually active adolescent.- - - - - - - - - - ranking = 5keywords = gland (Clic here for more details about this article) |
9/11. Intestinal metaplasia in stilboestrol-induced vaginal adenosis.We present an unusual case of vaginal adenosis with progressive intestinal metaplasia, previously undescribed, in a female patient exposed to stilboestrol in utero. Argentaffin cells were present within these areas, a feature not previously reported in benign vaginal adenosis. The development of the intestinal metaplasia coincided with the onset of a vaginal discharge so severe that, after 7 years, a vaginal resection was performed. Intestinal-type glands have been described in the cervix and ovary, almost invariably associated with malignancy. The possible role of intestinal metaplasia in the development of enteric-type neoplasms of the vagina is discussed.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
10/11. hydrocolpos, vaginal atresia, and urethrovaginal fistula in a neonate: abdomino-perineal-vaginal pull-through.The combination of high maternal estrogenic stimulation of the secretory glands of the reproductive tract of the newborn female and vaginal obstruction results in an abdominal mass due to vaginal distention (hydrocolpos). Prior experience with two infants with hydrocolpos (LG) led us to perform abdomino-perineal-vaginal pull-through, as advocated by Ramenofsky and Raffensperger, in the newborn period. So far as we can ascertain this is only the second infant so reported in the literature.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
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