Cases reported "Uveal Neoplasms"

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1/13. A case of pseudoadenomatous hyperplasia of ciliary body epithelium successfully treated by local resection.

    A case of pseudoadenomatous hyperplasia of ciliary body epithelium was reported in which malignant melanoma of ciliary body was suspected. Partial resection for histopathology was performed in conjunction with cataract extraction, anterior resection and photocoagulation. Histopathology of the tumor identified as pseudoadenomatous hyperplasia of ciliary body epithelium. Partial resection of ciliary body tumor may be an alternative method for its differential diagnosis rather than enucleation and iridocyclectomy.
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2/13. Pars plana vitrectomy in eyes containing a treated posterior uveal melanoma.

    PURPOSE: To determine the safety of pars plana vitrectomy in eyes containing a treated posterior uveal melanoma. DESIGN: Interventional case series. methods: Retrospective case series of patients with posterior uveal melanoma who underwent pars plana vitrectomy. Complications, vitreous cytology, local tumor control, and metastasis were assessed. RESULTS: Nine patients met study criteria. Tumors were treated with (125)I plaque radiotherapy (seven patients) or transpupillary thermotherapy (two patients). vitrectomy was performed for vitreous hemorrhage (five patients), macular pucker (two patients), macular hole (one patient), and rhegmatogenous retinal detachment (one patient). vitrectomy was performed at a mean of 24.7 months (range, 7-47 months) after melanoma treatment. Dispersion of tumor cells at vitrectomy was not observed in any patients. melanoma cells were detected in the vitreous aspirate in one of seven cases examined cytologically. This patient had intratumoral and vitreous hemorrhage before plaque radiotherapy, underwent combined vitrectomy/cataract extraction, and developed intraocular tumor dissemination 56 months after vitrectomy. No other patients developed intraocular tumor dissemination. At mean follow-up of 24 months (range, 3-63 months) after vitrectomy, none of the nine patients developed systemic metastasis. CONCLUSIONS: Pars plana vitrectomy rarely may lead to intraocular tumor dissemination, although the risk of this complication is probably low if the tumor has been treated and has responded to therapy before vitrectomy. vitrectomy should be approached with caution if a vitreous hemorrhage is present, especially if the hemorrhage occurred before tumor treatment, as this may seed tumor cells into the vitreous cavity.
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3/13. Topical thrombin-related corneal calcification.

    PURPOSE: To report a highly unusual case of corneal calcification after brief intraoperative use of topical thrombin. methods: A 44-year-old man underwent sclerouvectomy for ciliochoroidal leiomyoma, during which 35 UNIH/mL lyophilized bovine thrombin mixed with 9 mL of diluent containing 1500 mmol/mL calcium chloride was used. From the first postoperative day, corneal and anterior lenticular capsule calcifications developed, and corneal involvement slightly enlarged thereafter. RESULTS: A year later, 2 corneal punch biopsies confirmed calcification mainly in the Bowman layer. Topical treatment with 1.5% ethylenediaminetetraacetic acid significantly restored corneal clarity. Six months later, a standard extracapsular cataract extraction with intraocular lens placement improved visual acuity to 20/60. CONCLUSION: This case suggests that topical thrombin drops with elevated calcium concentrations may cause acute corneal calcification in Bowman layer and on the anterior lens capsule.
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4/13. Unsuspected uveal melanoma diagnosed after cataract extraction.

    Four cases of unsuspected uveal melanoma diagnosed after cataract extraction were found in a review of the records of enucleation specimens processed at our centre between 1974 and 1988. Similarities among the four cases included disparity in loss of visual acuity, unilateral angle-closure glaucoma, asymmetric cataract formation, inability to view the fundus and rapid flattening of the anterior chamber, with difficult closure at the time of surgery. Uveal melanoma should be suspected in any cataract patient presenting with one or more of these atypical clinical findings, and complete investigation, including A-scan and B-scan ultrasonography, is indicated.
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5/13. Massive pseudophakic pigment dispersion associated with an iris nevus.

    A 67-year-old woman examined 12 months following extracapsular cataract extraction had a massive pseudophakic pigment dispersion associated with diffuse corneal epithelial edema, mild uveitis, and secondary glaucoma. She underwent penetrating keratoplasty following removal of a posterior chamber intraocular lens (IOL), anterior vitrectomy, capsulectomy, and iris biopsy. Histopathologic examination revealed a pigmented iris nevus and signs of iris erosion by the IOL loop. Because 3 months later the eye developed streptococcal endophthalmitis and had to be eviscerated, we had the opportunity to examine the eye contents; we found no evidence of phakoanaphylactic uveitis.
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6/13. Uveal melanoma presenting after cataract extraction with intraocular lens implantation.

    Four patients underwent cataract extraction with implantation of intraocular lenses. Preoperative ultrasonography did not include a comprehensive diagnostic B-scan analysis. Postoperative examination revealed uveal melanomas. The clinical presentations as well as the histopathologic findings of the two enucleated eyes are discussed. These cases emphasize the necessity for B-scan ultrasonography prior to cataract surgery when media opacity prevents adequate visualization of the fundus.
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7/13. iris nodules in von Recklinghausen's Neurofibromatosis. Electron microscopic confirmation of their melanocytic origin.

    A 75-year-old man had generalized neurofibromatosis (NFT) with bilateral iris nodules and a mature cataract with elevated intraocular pressure in his left eye. At the time of intracapsular cataract extraction, a sector iridectomy was performed. Electron microscopic studies of the iris nodules within the iridectomy specimen unequivocally established that the spindle-shaped cells within the nodules were of melanocytic origin. We believe that the iris nodules in NFT represent melanocytic hamartomas.
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8/13. Fuchs' adenoma affecting the peripheral iris.

    An elevated, pigmented lesion of the peripheral iris developed in a 73-year-old woman. The lesion was believed to be a malignant melanoma and was excised at the time of routine cataract extraction. Pathologic examination disclosed a Fuchs' adenoma. These lesions are common in the elderly and are almost invariably clinically silent. This case, however, demonstrates that under rare circumstances a Fuchs' adenoma may induce cataractous changes or produce clinical findings that can mimic an iris melanoma.
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9/13. reticulum cell sarcoma of the uvea.

    A 57-year-old woman had recalcitrant uveitis with anterior chamber and vitreous cells. Three years later she was found to have reticulum cell sarcoma (RCS) of the left frontoparietal area; it responded well to radiotherapy. Two years later a cataract extraction was performed. Two years later a cataract extraction was performed, and one year afterward the uveitis worsened. Ocular RCS was suspected but was not confirmed by examination of smears of aqueous aspirates on two occasions. When nodular thickening of the iris developed the patient was treated with azathioprine for 14 days. During this time the lesion in the iris enlarged, and a large extrabulbar and disclosed RCS of the uveal tract, vitreous, and external limbal area. This case is exceptional in that it shows the association of uveal tract and CNS RCS. This case also supports the observation that the use of low-dosage immunosuppressive agents is potentially harmful in RCS.
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10/13. role of the CO2 laser in chorioretino-iridocyclectomy.

    Surgical extirpation of a uveal melanoma was performed by a sclerochorioretino iridocyclectomy using an externally focused CO2 laser. This was followed by a lens extraction and partial vitrectomy. The uveal melanoma proved to be of a mixed cell type. The minimal operative and postoperative hemorrhaging was attributed in part to the cauterizing cutting characteristics of the CO2 laser. Extensive coagulation necrosis produced by the CO2 laser precluded histopathologic evaluation of the resected tissue margin.
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