1/7. Phototoxic blisters from high frusemide dosage.Blistering of exposed areas has appeared in patients suffering from chronic renal failure treated with high doses of frusemide. The blistering, which resembles that occurring in nalidixic acid phototoxicity and in porphyria cutanea tarda, is considered phototoxic in nature.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
2/7. Thiazide-induced photosensitivity: a study of 33 subjects.The clinical features, action spectrum and subsequent course, are described in 33 subjects with thiazide-induced photosensitivity. The reaction appeared to be phototoxic in nature. The wavelengths involved were those of the longer UVA and, not infrequently, also the shorter UVB waveband. In most instances withdrawal of the drug resulted in clearance of the clinical reaction and a return of the action spectrum to normal. In the few subjects in whom the photosensitivity persisted, either in the form of the clinical reaction or an abnormal action spectrum, or both, either a specific photodermatosis was present or another potentially photoactive drug was being taken. In no instance, was there evidence of the induction of long-term chronic photosensitivity (persistent light reaction) following the withdrawal of the thiazide drug.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
3/7. Immediate sunburn-like reaction in a patient with formaldehyde photosensitivity.A 78-year-old man experienced pruritus, burning, and redness within minutes of exposure to sunlight. The immediacy as well as the temporary nature of the response was similar to that seen in solar urticaria, but in sharp contrast to the delayed reactions associated with sunburn and photocontact dermatitis. Photo-patch tests revealed a specific photosensitivity to formaldehyde. Despite its ubiquitous presence and its capacity to produce allergic contact dermatitis, formaldehyde, to my knowledge, has not been previously found to be a photosensitizer.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
4/7. perfume allergy due to oak moss and other lichens.During a period of 2 1/2 years, 7 of 2000 patients routinely tested at our laboratory revealed contact allergy to oak moss in perfumes. All reacted to a mixture of different lichens and to some specific lichen compounds. The sensitivity was probably induced by cosmetics containing lichen substances. The following 3 compounds caused reactions in all patients tested: atranorin, evernic and usnic acids. 3 patients were photosensitive, but stronger reactions were elicited by prolonged contact during occlusion of the patches and complete protection against light, rather than by irradiation alone. The data suggest that the sensitizing capacity of the lichen compounds is primarily of a contact rather than of a photocontact nature.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
5/7. nalidixic acid-induced photodermatitis after minimal sun exposure.More than 30 cases of bullous photodermatitis have already been associated with the administration of nalidixic acid. This reaction is reported in a 57-year-old woman whose sun exposure was minimal. nalidixic acid-induced photoreactions generally occur in females; they affect mainly the dorsal surfaces of the hands, feet, and legs, and usually do not involve the face. Blistering is always reported, and erythema is common. Dosage regimen and duration of treatment have little influence on the onset and severity of the reaction, which is probably of allergic nature. Its duration may be long, from three to six weeks, reexposure to the sun may trigger the reappearance of blistering for several months, even in the absence of a drug rechallenge.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
6/7. Clinical and experimental photosensitivity reaction to tilisolol hydrochloride.This report describes a patient who developed a photosensitivity reaction during the treatment of hypertension with tilisolol hydrochloride, which is a beta-blocker agent Although the data are insufficient to distinguish photoallergy and phototoxicity, clinical and histologic features suggested that the mechanism involved was photoallergic in nature. The action spectrum was mainly the ultraviolet A range. The reaction was reproducible on oral readministration of the drug and exposure to a low dose of UVA. Photopatch testing with the drug was also positive only in the patient. Although the experimental photoallergic reaction was not induced in the guinea pig, phototoxic potential was demonstrated in the animal. To our knowledge, a photosensitivity reaction due to tilisolol hydrochloride has not been previously reported in the English literature.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |
7/7. Photosensitivity associated with the smith-lemli-opitz syndrome.A case of severe photosensitivity in a girl with the smith-lemli-opitz syndrome is reported. Children with this recessively inherited metabolic disorder of cholesterol metabolism present with a variety of congenital abnormalities of the nervous system and internal organs in association with varying degrees of mental retardation. Photosensitivity is a feature which has previously only briefly been mentioned in the literature in association with this syndrome. However, more recently, it has become apparent that photosensitivity is not uncommon among children with the smith-lemli-opitz syndrome, although the nature of the photosensitivity in these patients has remained undefined. Our patient has suffered from sunlight intolerance since early infancy, with redness and pruritus of sun-exposed skin developing within minutes of sun exposure. Monochromator ultraviolet (UV) radiation and visible light testing revealed an immediate and persistent reaction to low-dose UVA at 350 nm, and an abnormal erythemal response to visible light at 400 nm.- - - - - - - - - - ranking = 1keywords = nature (Clic here for more details about this article) |